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181.
Yizheng Wei Yanyuan Ma Tanya P. Garcia Samiran Sinha 《Revue canadienne de statistique》2019,47(2):140-156
We propose a consistent and locally efficient method of estimating the model parameters of a logistic mixed effect model with random slopes. Our approach relaxes two typical assumptions: the random effects being normally distributed, and the covariates and random effects being independent of each other. Adhering to these assumptions is particularly difficult in health studies where, in many cases, we have limited resources to design experiments and gather data in long‐term studies, while new findings from other fields might emerge, suggesting the violation of such assumptions. So it is crucial to have an estimator that is robust to such violations; then we could make better use of current data harvested using various valuable resources. Our method generalizes the framework presented in Garcia & Ma (2016) which also deals with a logistic mixed effect model but only considers a random intercept. A simulation study reveals that our proposed estimator remains consistent even when the independence and normality assumptions are violated. This contrasts favourably with the traditional maximum likelihood estimator which is likely to be inconsistent when there is dependence between the covariates and random effects. Application of this work to a study of Huntington's disease reveals that disease diagnosis can be enhanced using assessments of cognitive performance. The Canadian Journal of Statistics 47: 140–156; 2019 © 2019 Statistical Society of Canada 相似文献
182.
A recent study conducted by Abad [1] described a method of determining the optimal price and lot size when the supplier offers all-unit quantity discounts. The author developed a procedure using centralized and decentralized approaches. According to the author's suggestion, further study is necessary to determine if the decentralized approach always provides an optimal solution. In the present study, an attempt is made to investigate the uniformity between the centralized and decentralized approaches and to verify whether the decentralized approach always yields optimal solutions. 相似文献
183.
Previous research has yielded a procedure for a retailer to determine the optimal lot size and selling price when a supplier offers all-unit quantity discounts and demand is a decreasing function of price. In this paper, we extend that research by allowing for shortages. An algorithm is presented that determines the optimal lot size, order level, and selling price for a class of demand functions, including the constant price-elasticity and linear demand functions. 相似文献