Measures of dependence for the multivariate t distribution with applications to the stock market

Two measures of dependence for multivariate t and Cauchy random variables are developed based on Kullback–Leibler number. The mutual information number T(X) is obtained in a closed expression form, as well as its asymptotic distribution. A dependence coefficient ρ₁, is defined (based on the Kullback–Leibler number) with the properties of ρ₁=0 indicating independence and ρ₁=1indicating degeneracy. Two real life examples from the stock market are used to analyze the level of dependence and correlation among stocks.     

On the Choice of Functional Forms: Summary of a Monte Carlo Experiment

The use of flexible functional forms is a standard practice in applied econometrics. Many flexible forms have been proposed. In this study, we investigate the behavior of three of them—the translog, the symmetric McFadden, and the symmetric generalized Barnett. Based on Monte Carlo experiments, we assess the ability of these forms to test theoretical properties and to measure technological characteristics.     

Vector correlation for elliptical distributions

A measure of multivariate correlation between two sets of vectors is considered when the underlying joint distribution is a member of the class of elliptical distributions. Its asymptotic distribution is derived under different situations and these results are used to test hypotheses on vector correlation when the underlying joint distribution is non-normal.     

Testing non-oblique hypotheses

This paper considers a likelihood ratio test for testing hypotheses defined by non-oblique closed convex cones, satisfying the so called iteration projection property, in a set of k normal means. We obtain the critical values of the test using the Chi-Bar-Squared distribution. The obtuse cones are introduced as a particular class of cones which are non-oblique with every one of their faces. Examples with the simple tree order cone and the total order cone are given to illustrate the results.     

On the minimum expected quantity for the validity of the chi-squared test in 2 2 2 tables

A 2 2 2 contingency table can often be analysed in an exact fashion by using Fisher's exact test and in an approximate fashion by using the chi-squared test with Yates' continuity correction, and it is traditionally held that the approximation is valid when the minimum expected quantity E is E S 5. Unfortunately, little research has been carried out into this belief, other than that it is necessary to establish a bound E>E*, that the condition E S 5 may not be the most appropriate (Martín Andrés et al., 1992) and that E* is not a constant, but usually increasing with the growth of the sample size (Martín Andrés & Herranz Tejedor, 1997). In this paper, the authors conduct a theoretical experimental study from which they ascertain that E* value (which is very variable and frequently quite a lot greater than 5) is strongly related to the magnitude of the skewness of the underlying hypergeometric distribution, and that bounding the skewness is equivalent to bounding E (which is the best control procedure). The study enables estimating the expression for the above-mentioned E* (which in turn depends on the number of tails in the test, the alpha error used, the total sample size, and the minimum marginal imbalance) to be estimated. Also the authors show that E* increases generally with the sample size and with the marginal imbalance, although it does reach a maximum. Some general and very conservative validity conditions are E S 35.53 (one-tailed test) and E S 7.45 (two-tailed test) for alpha nominal errors in 1% h f h 10%. The traditional condition E S 5 is only valid when the samples are small and one of the marginals is very balanced; alternatively, the condition E S 5.5 is valid for small samples or a very balanced marginal. Finally, it is proved that the chi-squared test is always valid in tables where both marginals are balanced, and that the maximum skewness permitted is related to the maximum value of the bound E*, to its value for tables with at least one balanced marginal and to the minimum value that those marginals must have (in non-balanced tables) for the chi-squared test to be valid.     

Accuracy of approximate progressively censored reliability sampling plans for exponential models

Reliability sampling plans provide an efficient method to determine the acceptability of a product based upon the lifelengths of some test units. Usually, they depend on the producer and consumer’s quality requirements and do not admit closed form solutions. Acceptance sampling plans for one- and two-parameter exponential lifetime models, derived by approximating the operating characteristic curve, are presented in this paper. The accuracy of these approximate plans, which are explicitly expressible and valid for failure and progressive censoring, is assessed. The approximation proposed in the one-parameter case is found to be practically exact. Explicit lower and upper bounds on the smallest sample size are given in the two-parameter case. Some additional advantages are also pointed out.     

A simple two-stage design for quantitative responses with application to a study in diabetic neuropathic pain

Two-stage designs offer substantial advantages for early phase II studies. The interim analysis following the first stage allows the study to be stopped for futility, or more positively, it might lead to early progression to the trials needed for late phase II and phase III. If the study is to continue to its second stage, then there is an opportunity for a revision of the total sample size. Two-stage designs have been implemented widely in oncology studies in which there is a single treatment arm and patient responses are binary. In this paper the case of two-arm comparative studies in which responses are quantitative is considered. This setting is common in therapeutic areas other than oncology. It will be assumed that observations are normally distributed, but that there is some doubt concerning their standard deviation, motivating the need for sample size review. The work reported has been motivated by a study in diabetic neuropathic pain, and the development of the design for that trial is described in detail.     

A copula-based Markov chain model for the analysis of binary longitudinal data

A fully parametric first-order autoregressive (AR(1)) model is proposed to analyse binary longitudinal data. By using a discretized version of a copula, the modelling approach allows one to construct separate models for the marginal response and for the dependence between adjacent responses. In particular, the transition model that is focused on discretizes the Gaussian copula in such a way that the marginal is a Bernoulli distribution. A probit link is used to take into account concomitant information in the behaviour of the underlying marginal distribution. Fixed and time-varying covariates can be included in the model. The method is simple and is a natural extension of the AR(1) model for Gaussian series. Since the approach put forward is likelihood-based, it allows interpretations and inferences to be made that are not possible with semi-parametric approaches such as those based on generalized estimating equations. Data from a study designed to reduce the exposure of children to the sun are used to illustrate the methods.     

To test or not to test: do workplace drug testing programs discourage employee drug use?

Workplace drug testing programs are often met with intense criticism. Despite resistance among labor and consumer groups and a lack of rigorous empirical evidence regarding effectiveness, drug testing programs have remained popular with employers throughout the 1990s and into the current century. The present study analyzed nationally representative data on over 15,000 US households to determine whether various types of workplace drug testing programs influenced the probability of drug use by workers. The study estimated several empirical specifications using both univariate and bivariate probit techniques. The specification tests favored the bivariate probit model over the univariate probit model. Estimated marginal effects of drug testing on any drug use were negative, significant, and relatively large, indicating that drug testing programs are achieving one of the desired effects. The results were similar when any drug use was replaced with chronic drug use in the models. These results have important policy implications regarding the effectiveness and economic viability of workplace anti-drug programs.     

Modeling the Adenoma and Serrated Pathway to Colorectal CAncer (ASCCA)

Several colorectal cancer (CRC) screening models have been developed describing the progression of adenomas to CRC. Currently, there is increasing evidence that serrated lesions can also develop into CRC. It is not clear whether screening tests have the same test characteristics for serrated lesions as for adenomas, but lower sensitivities have been suggested. Models that ignore this type of colorectal lesions may provide overly optimistic predictions of the screen‐induced reduction in CRC incidence. To address this issue, we have developed the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model that includes the adenoma‐carcinoma pathway and the serrated pathway to CRC as well as characteristics of colorectal lesions. The model structure and the calibration procedure are described in detail. Calibration resulted in 19 parameter sets for the adenoma‐carcinoma pathway and 13 for the serrated pathway that match the age‐ and sex‐specific adenoma and serrated lesion prevalence in the COlonoscopy versus COlonography Screening (COCOS) trial, Dutch CRC incidence and mortality rates, and a number of other intermediate outcomes concerning characteristics of colorectal lesions. As an example, we simulated outcomes for a biennial fecal immunochemical test screening program and a hypothetical one‐time colonoscopy screening program. Inclusion of the serrated pathway influenced the predicted effectiveness of screening when serrated lesions are associated with lower screening test sensitivity or when they are not removed. To our knowledge, this is the first model that explicitly includes the serrated pathway and characteristics of colorectal lesions. It is suitable for the evaluation of the (cost)effectiveness of potential screening strategies for CRC.