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861.
The welfare effects of vertically imposed exclusive territories and the appropriate antitrust policy toward them have long been debated. This paper sheds light on the exclusive-territory controversy by examing the effects of Indiana's 1979 ban on the grant of exclusive territories to beer wholesalers. Using time-series data for 1948–1990 we find the ban reduced beer consumption in Indiana by 6 percent. Coupled with previous evidence that Indiana's ban reduced price, our results suggest that exclusive territories in the beer industry increase demand and enhance welfare by stimulating the provision of dealer services.  相似文献   
862.
We discuss the development of German corporate governance in light of the hostile takeover of Mannesmann by Vodafone. The paper criticizes the stability hypothesis of Thomas Heinze in KZFSS 4/2001 and demonstrates the deep changes within German corporate governance, which we describe as hybrid convergence. Given trade-offs between corporate growth and profitability, the preferences of German management have changed towards greater emphasis on shareholder returns. This change is evident in the implementation of new profitability targets, end of cross-subsidization and concentration on core competences. Through incremental changes throughout the 1990s, the importance of market mechanisms has increased and been internalized within corporations. German corporate governance is moving toward a U.S. market model through hybrid processes of institutional layering and conversion.  相似文献   
863.
SUMMARY. The value of preschool education was already well recognised 30 years ago but the UK, unlike other European countries, has never developed a coherent system of public provision for young children. Reliance on private, voluntary and self-help facilities to fill the gaps has produced diversity but variable quality and little real choice. Over the same period attitudes and family structures have changed and there have been great advances in our understanding of how children's development can be supported and enhanced. The Children Act 1989 provides a legal framework for translating this knowledge into action. Yet at a time when a remarkable degree of professional consensus has been achieved on what is needed, we seem as far as ever from an adequate level of good quality provision. The article suggests that the reason is to be found in the marginalisation of our youngest children as the concern only of their parents and not of society as a whole.  相似文献   
864.
A common problem with medical surveillance programs using biomarkers is determining the optimal frequency of testing to minimize adverse health effects and cost. In the case of beryllium-exposed workers, frequency of testing for beryllium sensitization may be especially important. Recent studies indicate a lack of dose response for beryllium sensitization, but do support a dose response for the development of chronic beryllium disease (CBD). Though unproven, this implies that early identification of sensitization and immediate removal from exposure may reduce development of CBD. A model is proposed to project the optimal frequency of sensitization testing using the current beryllium lymphocyte proliferation test (BeLPT) to minimize disease-related costs, assuming that a positive BeLPT will precede CBD. Conversion rates for cumulative exposure to disease development were adapted from the literature and used with testing costs and cost of disease estimates in the model. The model was run assuming several test frequency regimes. Results support the use of periodic testing in line with the annual schedule proposed in the Final Chronic Beryllium Disease Prevention Program Rule (1999) following initial testing within three months of first beryllium exposure. The financial and health benefits of reducing the time from exposure to detection of early disease was also explored with the model and demonstrated as a highly desirable characteristic for an alternative test or improved BeLPT. Limitations of the approach are discussed as well as options for adapting this biomarker optimization methodology to consider biomarkers of other exposure-associated diseases.  相似文献   
865.
Therapy with families from ethnic and cultural backgrounds different from the therapist's own represents a particular challenge. How can the therapist be sufficiently mindful of ethnocultural factors and harness these to promote change, while at the same time avoiding the traps of stereotyping and labelling families? In this paper I hope to demonstrate, in addition to the worth of the case study approach, that information about cultural differences can be employed in a creative way by using it metaphorically rather than literally. A cultural artefact, the wayang kulit, the shadow theatre of Indonesia, is introduced as a metaphor for the process of therapy itself with a very stuck Anglo-Indonesian family.  相似文献   
866.
The internal pilot study design allows for modifying the sample size during an ongoing study based on a blinded estimate of the variance thus maintaining the trial integrity. Various blinded sample size re‐estimation procedures have been proposed in the literature. We compare the blinded sample size re‐estimation procedures based on the one‐sample variance of the pooled data with a blinded procedure using the randomization block information with respect to bias and variance of the variance estimators, and the distribution of the resulting sample sizes, power, and actual type I error rate. For reference, sample size re‐estimation based on the unblinded variance is also included in the comparison. It is shown that using an unbiased variance estimator (such as the one using the randomization block information) for sample size re‐estimation does not guarantee that the desired power is achieved. Moreover, in situations that are common in clinical trials, the variance estimator that employs the randomization block length shows a higher variability than the simple one‐sample estimator and in turn the sample size resulting from the related re‐estimation procedure. This higher variability can lead to a lower power as was demonstrated in the setting of noninferiority trials. In summary, the one‐sample estimator obtained from the pooled data is extremely simple to apply, shows good performance, and is therefore recommended for application. Copyright © 2013 John Wiley & Sons, Ltd.  相似文献   
867.
Pincus (1975) derived the null distribution of the likelihood-ratio test statistic for testing that the mean vector of a multivariate normal distribution is zero against the alternative that the mean vector lies in a circular cone. Under the null hypothesis, the likelihood-ratio test statistic has a chi-bar-squared distribution. We extend the results of Pincus by deriving the distribution of the likelihood-ratio test statistic under the alternative hypothesis. In a special case, the distribution is a “noncentral chi-bar-squared” distribution. To our knowledge, this is the first order-restricted testing problem for which the relationship between the null and alternative distributions of the test statistic is similar to the relationship in the linear-model setting. That is, the distribution of the likelihood-ratio test has a central form of a distribution under the null hypothesis and a noncentral form of the same distribution under the alternative.  相似文献   
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