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Biomarkers such as DNA adducts have significant potential to improve quantitative risk assessment by characterizing individual differences in metabolism of genotoxins and DNA repair and accounting for some of the factors that could affect interindividual variation in cancer risk. Inherent uncertainty in laboratory measurements and within-person variability of DNA adduct levels over time are putatively unrelated to cancer risk and should be subtracted from observed variation to better estimate interindividual variability of response to carcinogen exposure. A total of 41 volunteers, both smokers and nonsmokers, were asked to provide a peripheral blood sample every 3 weeks for several months in order to specifically assess intraindividual variability of polycyclic aromatic hydrocarbon (PAH)-DNA adduct levels. The intraindividual variance in PAH-DNA adduct levels, together with measurement uncertainty (laboratory variability and unaccounted for differences in exposure), constituted roughly 30% of the overall variance. An estimated 70% of the total variance was contributed by interindividual variability and is probably representative of the true biologic variability of response to carcinogenic exposure in lymphocytes. The estimated interindividual variability in DNA damage after subtracting intraindividual variability and measurement uncertainty was 24-fold. Inter-individual variance was higher (52-fold) in persons who constitutively lack the Glutathione S-Transferase M1 (GSTM1) gene which is important in the detoxification pathway of PAH. Risk assessment models that do not consider the variability of susceptibility to DNA damage following carcinogen exposure may underestimate risks to the general population, especially for those people who are most vulnerable.  相似文献   
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We offer a theoretical perspective to provide insight into why people are ambivalent about sex and why cultures regulate sex and attach symbolic meaning to it. Building on terror management theory, we propose that sex is problematic for humankind in part because it reminds us of our creaturely mortal nature. Two experiments investigated the effects of reminding people of the similarity between humans and other animals on their reactions to the physical aspects of sex. In Study 1, priming human-animal similarities led to increased accessibility of death-related thoughts after thinking about the physical but not romantic aspects of sex. In Study 2, when participants were reminded of similarities between humans and other animals, mortality salience resulted in decreased attraction to the physical but not romantic aspects of sex. In each study, priming thoughts about how humans are distinct from animals eliminated the association between sex and death.  相似文献   
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This article argues that the changes characterized by many commentators as announcing the 'information age' are better seen, not as heralding a new type of society, but as the continuation, consolidation and extension of capitalism - something which is accompanied by constant upheaval and innovation. The shift from conceiving the 'information society' as a result of technological breakthroughs to one which lays emphasis on the primacy of 'information' itself is observed. The importance especially of informational labour's 'flexibility' is regarded, not as indicative of a new age but of the requirements of globalized capitalism which engenders change the better to consolidate its practices. The instability of life today is ascribed, not to the upheavals resulting from the 'information revolution', but rather to the insatiable dynamic that has long been a distinguishing feature of capitalist enterprise. These processes are examined in terms of the shift from public to private provision of information and in the heightened uncertainty of existence today.  相似文献   
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A stochastic multitype model for the spread of an infectious disease in a community of heterogeneous individuals is analysed. In particular, estimates of R 0 (the basic reproduction number) and the critical vaccination coverage are derived, where estimation is based on final size data of an outbreak in the community. It is shown that these key parameters cannot be estimated consistently from data; only upper and lower bounds can be estimated. Confidence regions for the upper bounds are derived, thus giving conservative estimates of R 0 and the fractions necessary to vaccinate.  相似文献   
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Reinke T 《Physician executive》2007,33(4):42-4, 46-7
Health plans are profiling physicians on efficiency measures-producing new clinical, operational and strategic challenges for practices.  相似文献   
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This article develops a situational approach to understanding urban public life and, in particular, the production of urban territories. Our aim is to examine the ways in which city space might be understood as comprising multiple, shifting, mobile and rhythmed territories. We argue that such territories are best understood through attending to their everyday production and negotiation, rather than handling territory as an a priori construct. We develop this argument from the particular case of the street‐level politics of homelessness and street care. The experience of street homelessness and the provision of care in the public spaces of the city is characterised by precarious territorial claims made and lost. We describe some of the ways in which care work with rough sleepers is itself precarious; ‘homeless’, in lacking a distinct setting in which it might get done. Indeed, outreach work takes place within and affirms homeless territories. The affirmation of territory is shown to be central to the relationship developed between the workers and their rough sleeping clients. We also show, however, the ways in which outreach workers operate on territory not their own, twice over. Outreach work is precarious in that it is practised within, and can run counter to, other territorial productions in which the experience of urban need and the work and politics of care are entangled. In sum, this article aims to move beyond static and binary understandings by developing a mobile and situational approach to city space which recognises the intensive yet overlooked work of territorial production.  相似文献   
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