Specificity of the Tuberculin Skin Test and the T-SPOT.TB Assay Among Students in a Low–Tuberculosis Incidence Setting

Abstract

Objective: Interferon-γ release assays (IGRAs) are an important tool for detecting latent Mycobacterium tuberculosis infection (LTBI). Insufficient data exist about IGRA specificity in college health centers, most of which screen students for LTBI using the tuberculin skin test (TST). Participants: Students at a low–TB incidence college health center. Methods: TST and T-SPOT.TB were performed on prospectively recruited students. TB exposure risk was assessed using a questionnaire: Those at low risk were assumed to not have LTBI in order to calculate test specificity. Results: Of 184 students enrolled, 143 had results available for both TST and T-SPOT.TB. Agreement of the tests was 97% (kappa statistic 0.717; 95% confidence interval, 0.399–1.00). Among 124 low-risk students, specificity for TST and T-SPOT.TB were 98.4% and 100%, respectively. Conclusions: T-SPOT.TB specificity was high among low-risk students. Additional studies such as cost-effectiveness analyses using T-SPOT.TB as a single or confirmatory test to TST are needed to contribute to LTBI screening policy decisions.     

Eating Disorder Risk and Body Dissatisfaction Based on Muscularity and Body Fat in Male University Students

Abstract

Objective: To investigate the relationship between risk of eating disorders, body dissatisfaction, and perceptual attractiveness in male university students. Participants: Research was conducted January–April 2012 and involved 339 male and 441 female students. Methods: Eating disorder risk was assessed with the Eating Attitudes Test (EAT) and body dissatisfaction and perceptual attractiveness determined with the Bodybuilder Image Grid (BIG). Results: There was a positive correlation (r = .16, p < .01) between the EAT and fat dissatisfaction and a negative correlation (r = ?.14, p < .05) for muscle dissatisfaction, 28% of the males had an EAT score indicating that they were at risk for an eating disorder. Males chose a significantly more muscular and leaner body type than what females chose to be attractive. Conclusion: College-aged males may be at risk for eating disorders based on distortions in their perceived ideal body image, both for fat and muscle.     

Undergraduate Students' Attributions of Depicted Adult–Adolescent and Adolescent–Adolescent Sexual Interactions

The grayest areas of defining child sexual abuse appear to involve the age and sex of the individuals involved, resulting in a potential for different attributions regarding child sexual abuse across individuals. As a result, this study examines the responses of 262 male and female college student participants after viewing a series of hypothetical sexual abuse vignettes that depicted a 15-year-old victim that neither resisted nor encouraged the advances of a 15-, 25-, or 35-year-old perpetrator's actions. Gender roles and sexual attitudes were examined as potentially important covariates. Using a series of analyses of covariance, female participants gave more pro-victim ratings than male participants, and younger perpetrators were viewed less negatively than older perpetrators. Gender roles and sexual attitudes served as significant covariates. These findings emphasized the need to educate individuals about child sexual abuse and unwanted sexual contact involving individuals under the age of consent.     

Sexual Transformations and Intimate Behaviors in Romantic Relationships

To understand the association between sexual transformations (i.e., changes in sexual behavior for the partner), intimate behaviors, and relationship quality among couples in romantic relationships, this study used Actor Partner Interdependence Models to examine frequency of sexual transformations, feelings about sexual transformations, and intimate behaviors as predictors of relationship satisfaction among 96 couples (N = 192). Sexual transformations were also examined as a moderator of the association between intimate behavior and relationship satisfaction. Results indicated that relationship satisfaction was positively associated with partners’ frequent sexual transformations, actors’ positive feelings about sexual transformations, and intimate behavior from the partner. Further, in less intimate relationships, relationship satisfaction was greater when partners reported making more sexual transformations.     

An Initial Comparison of Live Instruction and Immersive Video Modes of Progressive Muscle Relaxation

Progressive Muscle Relaxation (PMR) is an established treatment for the reduction of anxiety, and has been delivered via live instruction, audiotape, videotape, and immersive video. Although previous research has compared some of these modes of PMR delivery, this is the first study to compare live instruction with immersive video. Participants completed one session of either live instruction or immersive video PMR, and outcome data was obtained for affect, satisfaction, and heart rate. Results indicate the comparability of live instruction and immersive video PMR conditions, as well as the overall effectiveness of a single session of PMR. Moreover, results suggest the potential superiority of immersive video over live instruction in terms of perceived value.     

A Probabilistic Arsenic Exposure Assessment for Children Who Contact Chromated Copper Arsenate (CCA)-Treated Playsets and Decks, Part 2: Sensitivity and Uncertainty Analyses

A probabilistic model (SHEDS-Wood) was developed to examine children's exposure and dose to chromated copper arsenate (CCA)-treated wood, as described in Part 1 of this two-part article. This Part 2 article discusses sensitivity and uncertainty analyses conducted to assess the key model inputs and areas of needed research for children's exposure to CCA-treated playsets and decks. The following types of analyses were conducted: (1) sensitivity analyses using a percentile scaling approach and multiple stepwise regression; and (2) uncertainty analyses using the bootstrap and two-stage Monte Carlo techniques. The five most important variables, based on both sensitivity and uncertainty analyses, were: wood surface residue-to-skin transfer efficiency; wood surface residue levels; fraction of hand surface area mouthed per mouthing event; average fraction of nonresidential outdoor time a child plays on/around CCA-treated public playsets; and frequency of hand washing. In general, there was a factor of 8 for the 5th and 95th percentiles and a factor of 4 for the 50th percentile in the uncertainty of predicted population dose estimates due to parameter uncertainty. Data were available for most of the key model inputs identified with sensitivity and uncertainty analyses; however, there were few or no data for some key inputs. To evaluate and improve the accuracy of model results, future measurement studies should obtain longitudinal time-activity diary information on children, spatial and temporal measurements of residue and soil concentrations on or near CCA-treated playsets and decks, and key exposure factors. Future studies should also address other sources of uncertainty in addition to parameter uncertainty, such as scenario and model uncertainty.     

Assessment and Application of National Environmental Databases and Mapping Tools at the Local Level to Two Community Case Studies

Communities are concerned over pollution levels and seek methods to systematically identify and prioritize the environmental stressors in their communities. Geographic information system (GIS) maps of environmental information can be useful tools for communities in their assessment of environmental‐pollution‐related risks. Databases and mapping tools that supply community‐level estimates of ambient concentrations of hazardous pollutants, risk, and potential health impacts can provide relevant information for communities to understand, identify, and prioritize potential exposures and risk from multiple sources. An assessment of existing databases and mapping tools was conducted as part of this study to explore the utility of publicly available databases, and three of these databases were selected for use in a community‐level GIS mapping application. Queried data from the U.S. EPA's National‐Scale Air Toxics Assessment, Air Quality System, and National Emissions Inventory were mapped at the appropriate spatial and temporal resolutions for identifying risks of exposure to air pollutants in two communities. The maps combine monitored and model‐simulated pollutant and health risk estimates, along with local survey results, to assist communities with the identification of potential exposure sources and pollution hot spots. Findings from this case study analysis will provide information to advance the development of new tools to assist communities with environmental risk assessments and hazard prioritization.     

Modeled Estimates of Soil and Dust Ingestion Rates for Children

Daily soil/dust ingestion rates typically used in exposure and risk assessments are based on tracer element studies, which have a number of limitations and do not separate contributions from soil and dust. This article presents an alternate approach of modeling soil and dust ingestion via hand and object mouthing of children, using EPA's SHEDS model. Results for children 3 to <6 years old show that mean and 95th percentile total ingestion of soil and dust values are 68 and 224 mg/day, respectively; mean from soil ingestion, hand‐to‐mouth dust ingestion, and object‐to‐mouth dust ingestion are 41 mg/day, 20 mg/day, and 7 mg/day, respectively. In general, hand‐to‐mouth soil ingestion was the most important pathway, followed by hand‐to‐mouth dust ingestion, then object‐to‐mouth dust ingestion. The variability results are most sensitive to inputs on surface loadings, soil‐skin adherence, hand mouthing frequency, and hand washing frequency. The predicted total soil and dust ingestion fits a lognormal distribution with geometric mean = 35.7 and geometric standard deviation = 3.3. There are two uncertainty distributions, one below the 20th percentile and the other above. Modeled uncertainties ranged within a factor of 3–30. Mean modeled estimates for soil and dust ingestion are consistent with past information but lower than the central values recommended in the 2008 EPA Child‐Specific Exposure Factors Handbook. This new modeling approach, which predicts soil and dust ingestion by pathway, source type, population group, geographic location, and other factors, offers a better characterization of exposures relevant to health risk assessments as compared to using a single value.     

The Making of the 2011 Revision of the Integrating Resources Manual

Abstract

This installment of Electronic Journal Forum describes the steps taken to revise Integrating Resources: A Cataloging Manual, which was first published in 2003. The revision reflects recent changes in MARC 21 coding and Program for Cooperative Cataloging practices, including provider-neutral record guidance. Examples in the manual were reviewed and purged of inconsistencies in coding.