Estimating Contaminant Dose for Intermittent Dermal Contact: Model Development, Testing, and Application

Assessments of aggregate exposure to pesticides and other surface contamination in residential environments are often driven by assumptions about dermal contacts. Accurately predicting cumulative doses from realistic skin contact scenarios requires characterization of exposure scenarios, skin surface loading and unloading rates, and contaminant movement through the epidermis. In this article we (1) develop and test a finite-difference model of contaminant transport through the epidermis; (2) develop archetypal exposure scenarios based on behavioral data to estimate characteristic loading and unloading rates; and (3) quantify 24-hour accumulation below the epidermis by applying a Monte Carlo simulation of these archetypal exposure scenarios. The numerical model, called Transient Transport through the epiDERMis (TTDERM), allows us to account for variable exposure times and time between exposures, temporal and spatial variations in skin and compound properties, and uncertainty in model parameters. Using TTDERM we investigate the use of a macro-activity parameter (cumulative contact time) for predicting daily (24-hour) integrated uptake of pesticides during complex exposure scenarios. For characteristic child behaviors and hand loading and unloading rates, we find that a power law represents the relationship between cumulative contact time and cumulative mass transport through the skin. With almost no loss of reliability, this simple relationship can be used in place of the more complex micro-activity simulations that require activity data on one- to five-minute intervals. The methods developed in this study can be used to guide dermal exposure model refinements and exposure measurement study design.     

Community Organization and Social Activism: Black Boston and the Antislavery Movement*

This paper uses data from an intensive study of Boston's antebellum black community to demonstrate how sustained social activism is embedded in the formal and informal institutions of the community. The social networks of cooperative institutions were primary factors in this community's ability to mobilize and sustain protest actions and to call attention to social injustice. This examination of antebellum black Boston indicates that the issue of slavery was crucial to social activism. This suggests that the presence of a salient issue which links the everyday lives of participants with a public issue may be an important factor in building a social movement based in a poor, relatively powerless community.     

Principal component and correspondence analysis of compositional data: some similarities

Principal component and correspondence analysis can both be used as exploratory methods for representing multivariate data in two dimensions. Circumstances under which the, possibly inappropriate, application of principal components to untransformed compositional data approximates to a correspondence analysis of the raw data are noted. Aitchison (1986) has proposed a method for the principal component analysis of compositional data involving transformation of the raw data. It is shown how this can be approximated by a correspondence analysis of appropriately transformed data. The latter approach may be preferable when there are zeroes in the data.