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Ha M. Dang Mark D. Krailo Todd A. Alonzo Wendy J. Mack John A. Kairalla 《Pharmaceutical statistics》2023,22(6):1031-1045
There is considerable debate surrounding the choice of methods to estimate information fraction for futility monitoring in a randomized non-inferiority maximum duration trial. This question was motivated by a pediatric oncology study that aimed to establish non-inferiority for two primary outcomes. While non-inferiority was determined for one outcome, the futility monitoring of the other outcome failed to stop the trial early, despite accumulating evidence of inferiority. For a one-sided trial design for which the intervention is inferior to the standard therapy, futility monitoring should provide the opportunity to terminate the trial early. Our research focuses on the Total Control Only (TCO) method, which is defined as a ratio of observed events to total events exclusively within the standard treatment regimen. We investigate its properties in stopping a trial early in favor of inferiority. Simulation results comparing the TCO method with alternative methods, one based on the assumption of an inferior treatment effect (TH0), and the other based on a specified hypothesis of a non-inferior treatment effect (THA), were provided under various pediatric oncology trial design settings. The TCO method is the only method that provides unbiased information fraction estimates regardless of the hypothesis assumptions and exhibits a good power and a comparable type I error rate at each interim analysis compared to other methods. Although none of the methods is uniformly superior on all criteria, the TCO method possesses favorable characteristics, making it a compelling choice for estimating the information fraction when the aim is to reduce cancer treatment-related adverse outcomes. 相似文献
84.
There is considerable speculation that female political empowerment could improve population health. Yet, evidence to date is limited, and explanations for why political empowerment would matter and the conditions under which this might be enhanced or muted are not well understood. In this article, we draw on theoretical work on the politics of representation to frame an investigation of whether increases in the percentage of females in a country’s parliament influence mortality rates. We further examine whether the relationship is conditioned by extent of democracy and economic and social development. Through multivariate longitudinal regression, we analyze four indicators of mortality in 155 countries spanning 1990 to 2014 with controls for initial country conditions, time-stable structural predispositions to higher mortality, and a number of time-varying potential confounders. Results indicate that a high level of female representation—30 % or greater in our models—has large negative associations with mortality, that these are particularly strong in lesser developed and weak democratic contexts, that high female political representation effectively offsets liabilities associated with low development, and that the relationships are robust to various operationalizations of social development. In the end, our research provides a particularly thorough accounting of the relationship between female political representation and population health, particularly by specifying the conditions under which female representation is most salient. In doing so, the research suggests important links between issues of female empowerment, political context, and developmental trajectories of countries more generally. 相似文献
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The present review critically evaluates evidence from adoption studies on the heritability of antisocial personality, interactions between genetic predispositions and the characteristics of adoptive mothers and fathers, and both the methodological and diagnostic shortcomings of existing studies. The article concludes with directions and suggestions for future research and practice. 相似文献
87.
There is considerable diversity in the literature regarding age and gender differences on career maturity and career decision status. There is also a dearth of data on high school samples. The present study reports cross‐sectional data from 1,971 Australian adolescents, ages 12.51‐17.99 years, who completed the Career Decision Scale (S. H. Osipow, C. G. Carney, J. Winer, B. Yanico, & M. Koschier, 1976) and the Career Development Inventory (Australian; J. Lokan, 1984). Results illustrated a developmental progression in career maturity, although a less uniform pattern emerged with gender differences. Findings regarding career indecision also presented a complex picture and highlight the need to focus on other demographic and contextual factors. 相似文献
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In this study, we explore narratives in relation to ‘fatness’, drawing on focus group interviews with parents, early years practitioners, teachers and young people. The study is located in a larger study on bullying and resilience, with no specific focus on obesity or ‘fatness’. Analysis of the interview data highlighted a recurrent focus on ‘fatness’ within the participants’ narratives, by labelling and stigmatising the ‘fat kid’ and ‘bigger children’. We conclude that obesity and fatness, as abnormalities, are now included in commonsense talk in relation to ‘easy targets’, victims and bullies. 相似文献
89.
Wendy D. Roth Marc‐David L. Seidel Dennis Ma Eiston Lo 《The International migration review》2012,46(2):310-361
The economic benefits to immigrants of taking jobs in ethnic workplaces, relative to the open economy, are heavily debated. We examine longitudinally differences across immigrant categories in how the choice of ethnic or non‐ethnic workplace influences the ethnic composition of social networks and how these factors impact immigrants’ economic success. Using the Longitudinal Survey of Immigrants to Canada, with data 6 months, 2 years, and 4 years after arrival, we find support for both sides of the ethnic economy debate when it is qualified by immigrant category. While economic immigrants benefit from non‐ethnic workplaces, family immigrants face economic penalties in the open economy and do better in ethnic workplaces. We argue that policies sorting immigrants into visa categories do much of the work of leading them into segmented paths of incorporation. 相似文献
90.
Catherine H. Stein Erica Hoffmann Erin E. Bonar Jaclyn E. Leith Kristen M. Abraham Alexis C. Hamill Shane W. Kraus Shinakee Gumber Wendy R. Fogo 《Journal of Family and Economic Issues》2013,34(2):200-210
Using a sample of 222 young adults attending college, the present study examined the relative contribution of young adults’ perceived economic pressures, financial coping and religious meaning-making coping strategies in accounting for variation in their reports of psychological well-being within the context of the United States economic crisis. Results suggest a direct relationship between perceived economic pressure and psychological well-being such that young adults who reported having to make more economic adjustments as a result of economic crisis also reported higher levels of depressed mood and anxiety. Young men and women who reported having to make fewer economic adjustments and being able to meet their material needs reported higher levels of life satisfaction. Regardless of young adults’ self-reported level of economic pressures, the use of education and communication financial coping strategies was related to lower levels of self-reported anxiety and depressed mood and greater life satisfaction. Viewing the financial crisis as a punishment from God was generally associated with young adults’ reports of greater depressed mood and less life satisfaction. Implication of findings for research and practice are discussed. 相似文献