Heterogeneous risk and time preferences

Assessing individuals’ time and risk preferences is crucial in domains such as health-related decisions (e.g., dieting, addictions), environmentally-friendly practices, and saving opportunities. We propose a new method to jointly elicit and estimate risk attitudes and intertemporal choices. We use a novel individual level estimation procedure based on a hierarchical Bayes methodology, which can integrate different functional forms for discounting and risk attitudes. This method provides individual level estimates, and allows us to explore the heterogeneity in the data. In addition, we report a negative correlation between risk and time preferences, implying that risk-seeking individuals are less patient and less willing to defer consumption.     

Progression-free survival in oncological clinical studies: Assessment time bias and methods for its correction

Progression-free survival (PFS) is a frequently used endpoint in oncological clinical studies. In case of PFS, potential events are progression and death. Progressions are usually observed delayed as they can be diagnosed not before the next study visit. For this reason potential bias of treatment effect estimates for progression-free survival is a concern. In randomized trials and for relative treatment effects measures like hazard ratios, bias-correcting methods are not necessarily required or have been proposed before. However, less is known on cross-trial comparisons of absolute outcome measures like median survival times. This paper proposes a new method for correcting the assessment time bias of progression-free survival estimates to allow a fair cross-trial comparison of median PFS. Using median PFS for example, the presented method approximates the unknown posterior distribution by a Bayesian approach based on simulations. It is shown that the proposed method leads to a substantial reduction of bias as compared to estimates derived from maximum likelihood or Kaplan–Meier estimates. Bias could be reduced by more than 90% over a broad range of considered situations differing in assessment times and underlying distributions. By coverage probabilities of at least 94% based on the credibility interval of the posterior distribution the resulting parameters hold common confidence levels. In summary, the proposed approach is shown to be useful for a cross-trial comparison of median PFS.     

基于纳米RuO_x的微型电化学胰岛素传感器

采用MEMS工艺及C-MEMS工艺制备碳微电极,在其上修饰纳米氧化钌Ru Ox颗粒后,表现出对胰岛素的电催化氧化特性,可实现胰岛素的电化学检测。以此构建的微型电化学胰岛素传感器,具有较好的电化学性能,其检测灵敏度为1 n A/μM,检测限为800 n M。该传感器结合流动注射分析系统,可获得稳定的测量,且所需样品量少,易实现长时、连续检测,具有潜在的临床应用价值,也可构建细胞传感器,在胰腺β细胞分泌胰岛素的机理研究中具有良好的应用前景。     

Exploring the Interaction Between Volunteering Status,Paid Job Characteristics and Quality of Volunteers’ Motivation on Mental Health

The literature on the health-promoting effects of community work has primarily dealt with the population in retirement age, yet the vast majority of volunteers are people still in the workforce. The aim of this study is to observe the relationship between volunteering and health within the context of working life, considering paid work conditions and motives to volunteer as moderating variables. We conducted an online survey with a sample of Swiss workers employed in different industries. Results show that volunteers with self-determined motives (but not with controlled motives) report lower levels of stress and burnout than non-volunteers. Moreover, volunteers in general (regardless of the quality of motivation) report higher levels of work engagement and well-being. Analyses further reveal an interaction effect for burnout and stress, where the difference between self-determined volunteers and non-volunteers becomes larger with unfavorable working conditions at their paid job, hinting at potential compensatory effects. Implications for future research and the voluntary sector are discussed.     

When Can Scientific Studies Promote Consensus Among Conflicting Stakeholders?

While scientific studies may help conflicting stakeholders come to agreement on a best management option or policy, often they do not. We review the factors affecting trust in the efficacy and objectivity of scientific studies in an analytical‐deliberative process where conflict is present, and show how they may be incorporated in an extension to the traditional Bayesian decision model. The extended framework considers stakeholders who differ in their prior beliefs regarding the probability of possible outcomes (in particular, whether a proposed technology is hazardous), differ in their valuations of these outcomes, and differ in their assessment of the ability of a proposed study to resolve the uncertainty in the outcomes and their hazards—as measured by their perceived false positive and false negative rates for the study. The Bayesian model predicts stakeholder‐specific preposterior probabilities of consensus, as well as pathways for increasing these probabilities, providing important insights into the value of scientific information in an analytic‐deliberative decision process where agreement is sought. It also helps to identify the interactions among perceived risk and benefit allocations, scientific beliefs, and trust in proposed scientific studies when determining whether a consensus can be achieved. The article provides examples to illustrate the method, including an adaptation of a recent decision analysis for managing the health risks of electromagnetic fields from high voltage transmission lines.     

„Unkündbar und nun?“ Lebensziel oder Schicksalsschlag – Chancen für eine faire Trennungskultur in der öffentlichen Verwaltung

Job security is seen as a very high value by employees regarding their professional objectives. Especially for employees in public service that secure professional status is one of their main reasons for working in public servance. Therefore, any dismissal may have severe negative effects on health of the employees and also negative effects on the image of the employer. From their perspective, an outplacement program could be an expedient element within the employee-life-cycle (recruiting—retention—exit/outplacement). A fair culture of separation in the organizational context in public sector which is accompanied by an outplacement program can give new perspectives to the employees and strengthen the image of the employer. An interview study with clients of an outplacement consultation will be mentioned. The participants were asked about their expectations and experiences with the consultation. Basically, the results clearly show that the consultant has a tremendous importance and is thus one of the most important success factors. If he or she meets the needs of the client, he or she works up the separation and promotes the confidence of his clients, nothing stands in the way of a successful consultation.     

Qualifikation von Ausbildungssupervisoren in der Sozialen Arbeit – Kontexte,Methoden und Erfahrungen

This article moots the issue of how to support students of social work and social pedagogy to develop the prerequisites for a professional exercise within their future vocational role by dint of supervision. Academical training has to offer spaces for reflecting the relationship between clients and their assistants and for the student’s self-development as well. Methodical settings are reflected for the vocational training of students. Of what kind are the relationships between knowledge transfer, practical guidance and supervision? This article pleads for supervision as an educational program and specifies the qualifications for supervisors.