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241.
242.
Control‐based imputation for sensitivity analyses in informative censoring for recurrent event data 下载免费PDF全文
Fei Gao Guanghan F. Liu Donglin Zeng Lei Xu Bridget Lin Guoqing Diao Gregory Golm Joseph F. Heyse Joseph G. Ibrahim 《Pharmaceutical statistics》2017,16(6):424-432
In clinical trials, missing data commonly arise through nonadherence to the randomized treatment or to study procedure. For trials in which recurrent event endpoints are of interests, conventional analyses using the proportional intensity model or the count model assume that the data are missing at random, which cannot be tested using the observed data alone. Thus, sensitivity analyses are recommended. We implement the control‐based multiple imputation as sensitivity analyses for the recurrent event data. We model the recurrent event using a piecewise exponential proportional intensity model with frailty and sample the parameters from the posterior distribution. We impute the number of events after dropped out and correct the variance estimation using a bootstrap procedure. We apply the method to an application of sitagliptin study. 相似文献
243.
Guided by Cantor’s social care model, this study identified individual, family, and social support factors that influence urban older adults’ need for home- and community-based services, including medical and rehabilitation, instrumental care and support, and psychosocial services. The data were extracted from the Sample Survey on Aged Population in Urban/Rural China conducted by the China Research Center on Aging in 2006. Results from multiple logistic regression show that older adults’ need for medical and rehabilitation services is significantly related to instrumental activities of daily living, depression, not having filial children, friend support networks, and having a confidant. Older adults’ need for instrumental care and support is related to their educational attainment, financial strain, instrumental activities of daily living, not living with children, and friend support networks. Finally, older adults’ need for psychosocial services is significantly related to educational attainment, depression, not being married, friend support networks, and having a confidant. Implications for social service development are discussed. 相似文献
244.
Jinyu Liu Man Guo Ling Xu Weiyu Mao Iris Chi 《Journal of Ethnic & Cultural Diversity in Social Work》2017,26(3):167-184
This study explored whether and how family relationships and social connections influence depressive symptoms of older migrants and older adults in transnational families using the data gathered from a cross-sectional survey in Los Angeles, California, United States, and Beijing, China. Regression results showed that the older migrants reported significantly higher levels of depression than the elders in transnational families. The findings highlight the importance of maintaining close family relations and having large friendship networks for older adults in international migrant families. 相似文献
245.
Measuring the difference between two Gini indexes is important in comparing the inequality between two groups. This paper systematically provides confidence intervals for this difference. First, normal approximation- and bootstrap-based confidence intervals are provided for the difference. Second, empirical likelihood (EL)-based confidence intervals are proposed according to a ratio statistic that is proven to have a weighted Chi-squared distribution with one degree of freedom. Third, two calibration approaches are established to improve the undercoverage issue of the EL method; these two approaches are augmented EL and bootstrap-calibrated EL. Monte Carlo simulations show that bootstrap-calibrated EL generally outperforms other methods in constructing confidence intervals. In the simulations, these methods are compared with the permutation method to test the equality of two Gini indexes. Lastly, these methods are applied to real data. 相似文献
246.
247.
Feng Xu 《Journal of applied statistics》2017,44(4):642-648
In searching for the optimal inventory control policy, the objective is to minimize the expected total costs related, of which the shortage cost is an important element. Due to the difficulty in calculating the indirect cost of the loss of goodwill resulted from the shortage, practitioners and researchers often simply assume a fixed penalty cost on the inventory shortage or switch to the alternative method by assigning a specific customer service level. The development of an appropriate tool for measuring the shortage cost can help a business control the total costs and improve the productivity more effectively. This paper proposes probabilistic measurements of the shortage cost, based on mathematical relationship between the cost and the shortage amount. The derived closed-form estimates of the expected shortage cost value can then be applied to support the determination of the optimal inventory control policy. 相似文献
248.
Liwen Xu 《统计学通讯:理论与方法》2017,46(7):3308-3320
This paper presents parametric bootstrap (PB) approaches for hypothesis testing and interval estimation of the fixed effects and the variance component in the growth curve models with intraclass correlation structure. The PB pivot variables are proposed based on the sufficient statistics of the parameters. Some simulation results are presented to compare the performance of the proposed approaches with the generalized inferences. Our studies show that the PB approaches perform satisfactorily for various cell sizes and parameter configurations, and tends to outperform the generalized inferences with respect to the coverage probabilities and powers. The PB approaches not only have almost exact coverage probabilities and Type I error rates, but also have the shorter expected lengths and the higher powers. Furthermore, the PB procedure can be simply carried out by a few simulation steps. Finally, the proposed approaches are illustrated by using a real data example. 相似文献
249.
在高校建设项目实施的整个过程中,建设前期的造价控制对整个工程项目的造价影响极大,因此高校内审部门应对建设前期的造价审计予以特别重视。然而,高校对建设前期造价审计的运用还处于初步阶段,仍没有形成成熟的操作体系。文章从投资决策、设计、预算编制3个阶段对审计策略分别予以探究,为高校内审人员开展项目前期审计提供思路和实践依据,力争使高校建设项目造价从源头上得到有效控制,提高投资效益。 相似文献
250.
Whether government‐based forms of food assistance such as the Supplemental Nutrition Assistance Program (SNAP), communal efforts including food pantries, aid from friends and family, or alternative means such as gardening are the appropriate means to reduce the prevalence of household food insecurity is a continuous source of policy contention. To inform this debate, we examine the relative importance of these forms of food assistance and acquisition to a sample of U.S. older adults from the 2010 Brazos Valley Health Assessment of central Texas households that have been stratified by income eligibility for SNAP, low‐income SNAP ineligibility, and above low income status. To identify how membership in these socioeconomic groups constrains household capacity to acquire sufficient food to maintain an adequate and healthy diet, we explore the varied associations of assets received from government; communal and intimate social networks; and alternative food sources such as gardening, hunting, and fishing with household food security across socioeconomic status, while examining the importance of place of residence on the use of capital assets. SNAP participation was the only specific capital asset associated with all levels of food insecurity for both SNAP‐eligible and ineligible low‐income groups, thus emphasizing the continued importance of food assistance among poverty‐level older adults. 相似文献