Development and application of a dose–response model for Elizabethkingia spp

Elizabethkingia spp. are common environmental pathogens responsible for infections in more vulnerable populations. Although the exposure routes of concern are not well understood, some hospital-associated outbreaks have indicated possible waterborne transmission. In order to facilitate quantitative microbial risk assessment (QMRA) for Elizabethkingia spp., this study fit dose–response models to frog and mice datasets that evaluated intramuscular and intraperitoneal exposure to Elizabethkingia spp. The frog datasets could be pooled, and the exact beta-Poisson model was the best fitting model with optimized parameters α  = 0.52 and β = 86,351. Using the exact beta-Poisson model, the dose of Elizabethkingia miricola resulting in a 50% morbidity response (LD₅₀) was estimated to be approximately 237,000 CFU. The model developed herein was used to estimate the probability of infection for a hospital patient under a modeled exposure scenario involving a contaminated medical device and reported Elizabethkingia spp. concentrations isolated from hospital sinks after an outbreak. The median exposure dose was approximately 3 CFU/insertion event, and the corresponding median risk of infection was 3.4E-05. The median risk estimated in this case study was lower than the 3% attack rate observed in a previous outbreak, however, there are noted gaps pertaining to the possible concentrations of Elizabethkingia spp. in tap water and the most likely exposure routes. This is the first dose–response model developed for Elizabethkingia spp. thus enabling future risk assessments to help determine levels of risk and potential effective risk management strategies.     

Enterprising Education: Doing Away with the Public School System

We critically examine the accepted notion that primary education is a legitimate and necessary function of the state. The notion is based upon three tenets: 1) public education is a necessary condition for democracy, 2) the market will not provide equal access and quality of education to all, and 3) education represents an external economy. Each tenet is addressed and evaluated according to its merits. In doing so, we also contrast the fulfillment of the ends implicit in the tenets under state and market provisions. We conclude that the state provision of primary education cannot be justified by these goals, and that market provision is a preferable alternative. This revised version was published online in July 2006 with corrections to the Cover Date.     

MAXIMUM LIKELIHOOD ESTIMATION FOR A POISSON RATE PARAMETER WITH MISCLASSIFIED COUNTS

This paper proposes a Poisson‐based model that uses both error‐free data and error‐prone data subject to misclassification in the form of false‐negative and false‐positive counts. It derives maximum likelihood estimators (MLEs) for the Poisson rate parameter and the two misclassification parameters — the false‐negative parameter and the false‐positive parameter. It also derives expressions for the information matrix and the asymptotic variances of the MLE for the rate parameter, the MLE for the false‐positive parameter, and the MLE for the false‐negative parameter. Using these expressions the paper analyses the value of the fallible data. It studies characteristics of the new double‐sampling rate estimator via a simulation experiment and applies the new MLE estimators and confidence intervals to a real dataset.     

配额制对近期国内电影市场自给率的影响

此项研究主要考察电影配额制及其它相关因素对电影市场自给率的影响。回归模型表明，配额制与自给率正相关的假设并不成立，因而暗示了配额制或许并不能有效的限制国外电影进入本国市场。国内生产总值，票房收益和制作投资被认为是决定自给率的最强有力的三大因素，而文化折扣和英语语言是非决定性因素。     

Adolescent Women's Recommendations for Enhanced Parent-Adolescent Communication About Sexual Behavior

Family communication about adolescent sexual health and behavior promotes adolescent health and family connectedness. However, few studies seek the perspective of adolescents regarding their recommended strategies for family communication. Findings of a survey of female adolescent family planning patients (n = 249) indicated adolescent recommendations for better family communication included treat teen as an equal, 63%; increase parental knowledge about lifestyle and peer pressures, 61%, and improve parental listening skills, 61%. There were no statistically significant differences according to age, pregnancy history, or school enrollment status for suggested strategies for improved communication with parents. Sexually active adolescent daughters expressed interest in maintaining family connectedness and support with increased time for family activities as well as increased quality and quantity of dialogue between the adolescent girl and her parents.     

Assessing progress against the size of the problem

To summarize articles with the depth and range of the nine in this collection is difficult. What the articles demonstrate as a whole is that a great deal of activity is under way in the arena of connecting child welfare and substance abuse services, with a growing body of documentation accompanying it. The articles bode good news in that they indicate a broadening awareness of the interconnectedness of these issues, and they highlight a number of creative and effective programs that have been established to mitigate the problems. Tremendous challenges-from funding to outcomes research-however, are also made evident in this body of work.