冷却剂参数对铣槽喷管低周疲劳寿命的影响

采用有限体积流固耦合计算方法、非线性有限元热结构耦合分析方法和局部应变法研究大面积比铣槽喷管三维再生冷却槽道在循环工作条件下的热结构变形与低周疲劳寿命,并对比分析了冷却剂质量流量与入口温度对铣槽喷管疲劳使用寿命的影响。计算结果表明,铣槽喷管热结构响应呈现复杂的三维效应,应变较大位置主要分布在与肋连接的内衬区域,喷管中部的残余应变量最大;冷却槽道低周疲劳寿命分布和热结构响应基本一致,最小寿命位于喷管中部与肋相连的内衬区域燃气侧;随冷却剂质量流量增加,铣槽喷管低周疲劳寿命不断提高;随冷却剂入口温度增加喷管尾部低周疲劳寿命值不断降低,而喷管中前部的低周疲劳寿命值却不断提高,当冷却剂入口温度为280K左右时,本文的铣槽喷管总体使用寿命达到最大。      

Assessing Effects on Long-term Survival after Early Termination of Randomized Trials

In this paper we present an approach to using historical control data to augment information from a randomized controlled clinical trial, when it is not possible to continue the control regimen to obtain the most reliable and valid assessment of long term treatment effects. Using an adjustment procedure to the historical control data, we investigate a method of estimating the long term survival function for the clinical trial control group and for evaluating the long term treatment effect. The suggested method is simple to interpret, and particularly motivated in clinical trial settings when ethical considerations preclude the long term follow-up of placebo controls. A simulation study reveals that the bias in parameter estimates that arises in the setting of group sequential monitoring will be attenuated when long term historical control information is used in the proposed manner. Data from the first and second National Wilms' Tumor studies are used to illustrate the method.     

注重素质培养,实现教育实习的目的

面对实习学校设备参差不齐,指导教师素质有高有低,实习学生来源、民族、性别比例不均的状况,我校教育实习相应地采取了城乡结合式、基地式等多种形式.在实习中,通过准备、实习、总结三个阶段,加强学生教风、教态、仪表、行为、着装、语言和板书的专门素质教育,以期达到教育实习的目的.     

关于扩大内需与适度消费的思考

文章从扩大内需、保持适度消费角度对在新旧体制转换时期,如何使国民经济保持持续稳定快速增长进行了探讨,指出这应该是政府和商家的共同行为,政府的政策性指导,将有助于建立公众正确消费观念.     

我国政府统计中多层次推断问题讨论

当前,多层次推断问题已成为我国在政府统计中推广抽样调查所面临的最大难题。本文回顾了现有解决多层次推断问题的方法,指出这些方法在使用上的限制;提出从改进估计的角度解决多层次推断问题,讨论了借助辅助信息改进估计的方法和建立统计模型进行推估的方法,并指出各种方法的优劣和适用情况;简要探讨了大数据背景下对解决多层次推断问题的一些启示。     

An efficient sequential design of clinical trials

We propose an efficient group sequential monitoring rule for clinical trials. At each interim analysis both efficacy and futility are evaluated through a specified loss structure together with the predicted power. The proposed design is robust to a wide range of priors, and achieves the specified power with a saving of sample size compared to existing adaptive designs. A method is also proposed to obtain a reduced-bias estimator of treatment difference for the proposed design. The new approaches hold great potential for efficiently selecting a more effective treatment in comparative trials. Operating characteristics are evaluated and compared with other group sequential designs in empirical studies. An example is provided to illustrate the application of the method.     

国际上非基准年购买力平价推算方法评价

 全球国际比较项目大约每隔5年或6年调查一次,有关国际组织应用总量外推法、分类项目外推法、基期滚动法和简缩信息法等方法推算非基准年的PPP数据,以便取得完整的连续时间序列。本文对国际上常用的各种非基准年PPP推算方法和结果作详细分析、评价。     

Reducing bias of the maximum-likelihood estimation for the truncated Pareto distribution

The Pareto distribution is an important distribution in statistics, which has been widely used in finance, physics, hydrology, geology, astronomy, and so on. Even though the parameter estimation for the Pareto distribution has been well established in the literature, the estimation problem for the truncated Pareto distribution becomes complex. This article investigates the bias and mean-squared error of the maximum-likelihood estimation for the truncated Pareto distribution, and some useful results are obtained.     

Maximum likelihood estimation of the bimodal failure rate for censored and tied observations

DIMITROV, RACHEV and YAKOVLEV ( 1985 ) have obtained the isotonic maximum likelihood estimator for the bimodal failure rate function. The authors considered only the complete failure time data. The generalization of this estimator for the case of censored and tied observations is now proposed.