Bayesian–frequentist hybrid model with application to the analysis of gene copy number changes

Gene copy number (GCN) changes are common characteristics of many genetic diseases. Comparative genomic hybridization (CGH) is a new technology widely used today to screen the GCN changes in mutant cells with high resolution genome-wide. Statistical methods for analyzing such CGH data have been evolving. Existing methods are either frequentist's or full Bayesian. The former often has computational advantage, while the latter can incorporate prior information into the model, but could be misleading when one does not have sound prior information. In an attempt to take full advantages of both approaches, we develop a Bayesian-frequentist hybrid approach, in which a subset of the model parameters is inferred by the Bayesian method, while the rest parameters by the frequentist's. This new hybrid approach provides advantages over those of the Bayesian or frequentist's method used alone. This is especially the case when sound prior information is available on part of the parameters, and the sample size is relatively small. Spatial dependence and false discovery rate are also discussed, and the parameter estimation is efficient. As an illustration, we used the proposed hybrid approach to analyze a real CGH data.     

赞助性流动与素质教育

目前在我国学校教育中有很多背离素质教育的现象。产生这些现象的主要原因是素质教育在许多方面与赞助性流动不一致 ,但又迫于这一规范对教育制度所释放出的恒常的张力 ,教育制度不得不作出某些让步 ,而导致素质教育不能真正、彻底地实施。要解决这一问题 ,应转变人们的思想观念 ,改革社会的用人标准以及改革我国现行的高考制度等。     

永登方言的少数民族语言痕迹与文化现象

永登县历史悠久,是通往河西走廊的门户.在历史上,永登汉族与当地的藏、蒙、满、回等少数民族长期杂居,形成了独具特色的方言与文化.本文从语音、语法以及文化的角度,对当地汉语方言中的少数民族语言文化现象进行了初步探讨.     

蒙古族传统奶食品的制作技艺与相关民俗探析

本文在田野实践和田野调查的基础上,将蒙古族传统奶食品制作技艺分为自然凝固法、搅拌发酵法、温火烧制法三种类型,同时对蒙古族在食用奶食品过程中形成的一整套与精神文化相关的饮食礼仪和饮食习俗进行了探讨。     

韩国金泳三政府反腐廉政新举措述评

分析和探讨韩国政府要求公布官员私人财产的命令、金融领域实行真实姓名制度、税制改革动向等主要反腐措施,并认为上述举措已获初步成效。鉴于亚洲国家社会经济发展和历史文化传统的共通性,韩国的廉政改革值得参考和借鉴。     

吴兆骞辞赋概观

吴兆骞的身世遭际及其诗赋在当世及后世都充满了悲悒色彩。他的诗歌迥绝一时;他的赋作虽然只有八篇,却也是饱含身世之感,内蕴深厚,充分表现了他的才气与笔力。     

实现农村剩余劳动力有序流动的思考

实现农村剩余劳动力的有序流动,既是涉及农民自身利益的重要问题,也是事关整个经济和社会发展的重要课题。农村剩余劳动力有序流动对社会经济协调发展起着重要作用,但在目前的实际工作中存在较多的问题,必须结合实际进行分析,并找到有效的解决方法。     

网络问政的常态化与制度化建设

网络问政是中国政治文化的新亮点,对构建和谐社会意义重大。实现网络问政的常态化和制度化是推进中国政治文化建设的必然选择。为此,应探索符合实际的特色性运行模式,整合群众问政渠道．扩大网络问政内容的覆盖面,深化问题答复制与责任追究制,发展健康向上的网络文化。     

我国茶叶生产流通信息服务模式研究

茶叶生产流通信息服务模式的构建能够有效解决信息不对称问题和提升生产流通各环节效率,按照信息服务主体、客体、环节、内容的不同将茶叶生产流通信息服务模式分为农技站、茶叶合作社、龙头企业、批发市场以及“互联网+”平台模式五种。茶叶生产流通信息服务能力评价体系从信息服务设施、内容、队伍、效益、保障机制5个方面选取17个二级指标组成,采用层次分析法和模糊综合评价法对五种模式进行比较分析发现,“互联网+”平台模式综合能力更高,茶叶云平台是未来发展的重要趋势。     

A multivariate regression model for continuous genetic traits

Summary.  In many commonly used models for multivariate traits, the likelihood is specified as a mixture of nested sums of products over the unobserved genotypes of all the family members, in which the familial covariance matrices vary in size and structure for different families, and their sizes can be immense for large family units. These issues pose computational difficulties in many applications. Bonney's compound regressive model for univariate traits simplifies the familial covariance structure and reduces the mixture of nested sums only to the parent–offspring level, thus enhancing computation significantly. This model has been extended to the multivariate case in the absence of unobserved genotypes. Here, we further extend this model to incorporate major genes, covariates and multiple loci. As is typical in practice, this causes new computational difficulties. We study the computational issues and explore the behaviour of this extended model.