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51.
52.
After initiation of treatment, HIV viral load has multiphasic changes, which indicates that the viral decay rate is a time-varying process. Mixed-effects models with different time-varying decay rate functions have been proposed in literature. However, there are two unresolved critical issues: (i) it is not clear which model is more appropriate for practical use, and (ii) the model random errors are commonly assumed to follow a normal distribution, which may be unrealistic and can obscure important features of within- and among-subject variations. Because asymmetry of HIV viral load data is still noticeable even after transformation, it is important to use a more general distribution family that enables the unrealistic normal assumption to be relaxed. We developed skew-elliptical (SE) Bayesian mixed-effects models by considering the model random errors to have an SE distribution. We compared the performance among five SE models that have different time-varying decay rate functions. For each model, we also contrasted the performance under different model random error assumptions such as normal, Student-t, skew-normal, or skew-t distribution. Two AIDS clinical trial datasets were used to illustrate the proposed models and methods. The results indicate that the model with a time-varying viral decay rate that has two exponential components is preferred. Among the four distribution assumptions, the skew-t and skew-normal models provided better fitting to the data than normal or Student-t model, suggesting that it is important to assume a model with a skewed distribution in order to achieve reasonable results when the data exhibit skewness. 相似文献
53.
"邻里汇"作为一种社区公共服务供给新模式,在公共服务领域有其独特的优势."邻里汇"汇集了养老、康复、助餐、助浴和社区生活服务等功能,成为社区居民休闲的汇聚地.要尽力争取让各年龄、各阶层的居民都能走出家门,一起加入"邻里汇"的大家庭中.有了社区居民的积极参与,才能将"邻里汇"建设成为促进社区和谐、满足多元需求的社区服务载体,营造出睦邻互助的良好氛围. 相似文献
54.
随着经济全球化发展,文化的交流日益频繁,文化的多样性与创新的需求使人们接受了文化融合设计.该文从入口空间的角度阐释了中西方建筑入口的发展演变,运用比较的方法分析和总结了中西方传统建筑入口空间的差异,从中借鉴其设计精髓和文化,以便探索现代入口空间的中西方文化融合设计方法.希望该文的论述能有助于我国入口空间设计的发展. 相似文献
55.
英语教学中的文化渗透 总被引:2,自引:0,他引:2
英语国家社会文化和汉语文化存在着很大差异,在英语教学中,不但要教会学生英语语言本身,也要传授给学生英语语言中所承载的社会文化内涵,使学生学到真正地道的英语,从而真正达到文化交流的目的。 相似文献
56.
劳务派遣作为一种灵活的用工形式,受到我国各类用人单位的青睐和广泛运用。2013年《劳动合同法》修订弥补了我国劳务派遣制度上的不足,但由于起步时间较晚,加上制度的复杂性,存在工伤赔偿制度的责任划分不清晰、工伤保险待遇先行支付具体操作存在困难、异地劳务派遣工伤保险制度执行不明确等方面的问题。我国需要从确立《劳动合同法》中派遣单位与用工单位的具体责任分担制度、完善劳务派遣工伤待遇先行支付规定、明确异地保险制度相关规定等方面入手,进一步完善工伤保险制度在劳务派遣用工中的适用,有效保护被派遣劳动者的合法权益。 相似文献
57.
In high-dimensional linear regression, the dimension of variables is always greater than the sample size. In this situation, the traditional variance estimation technique based on ordinary least squares constantly exhibits a high bias even under sparsity assumption. One of the major reasons is the high spurious correlation between unobserved realized noise and several predictors. To alleviate this problem, a refitted cross-validation (RCV) method has been proposed in the literature. However, for a complicated model, the RCV exhibits a lower probability that the selected model includes the true model in case of finite samples. This phenomenon may easily result in a large bias of variance estimation. Thus, a model selection method based on the ranks of the frequency of occurrences in six votes from a blocked 3×2 cross-validation is proposed in this study. The proposed method has a considerably larger probability of including the true model in practice than the RCV method. The variance estimation obtained using the model selected by the proposed method also shows a lower bias and a smaller variance. Furthermore, theoretical analysis proves the asymptotic normality property of the proposed variance estimation. 相似文献
58.
Yunlu Jiang Yan Wang Jiantao Zhang Baojian Xie Jibiao Liao Wenhui Liao 《Journal of applied statistics》2021,48(2):234
This paper studies the outlier detection and robust variable selection problem in the linear regression model. The penalized weighted least absolute deviation (PWLAD) regression estimation method and the adaptive least absolute shrinkage and selection operator (LASSO) are combined to simultaneously achieve outlier detection, and robust variable selection. An iterative algorithm is proposed to solve the proposed optimization problem. Monte Carlo studies are evaluated the finite-sample performance of the proposed methods. The results indicate that the finite sample performance of the proposed methods performs better than that of the existing methods when there are leverage points or outliers in the response variable or explanatory variables. Finally, we apply the proposed methodology to analyze two real datasets. 相似文献
59.
"整合"和"民族整合"两词在当前的学术论著中出现频繁,学者们对"民族整合"的理解也各不相同.实现学术话语的趋同性认识和使用,有利于消除歧异性理解,形成认知上的共识.本文在对"民族整合"的不同表述进行梳理的基础上,提出了自己的主张,并认为"民族整合"是不同于民族融合和民族同化的功能和过程. 相似文献
60.
牛妍 《佳木斯大学社会科学学报》2015,(2):73-74,78
随着自媒体时代的兴起,高校培育和践行社会主义核心价值观,应全面把握和深入分析自媒体时代的特征及其影响,分析在自媒体时代的冲击下,高校社会主义核心价值观教育所面临的机遇和挑战,探讨如何用多维度策略推进高校社会主义核心价值观的政治认同。 相似文献