On sequential closed testing dose groups with a control

Methods for a sequential test of a dose-response effect in pre-clinical studies are investigated. The objective of the test procedure is to compare several dose groups with a zero-dose control. The sequential testing is conducted within a closed family of one-sided tests. The procedures investigated are based on a monotonicity assumption. These closed procedures strongly control the familywise error rate while providing information about the shape of the dose-responce relationship. Performance of sequential testing procedures are compared via a Monte Carlo simulation study. We illustrae the procedures by application to a real data set.     

Generalized additive mixed models

Following the extension from linear mixed models to additive mixed models, extension from generalized linear mixed models to generalized additive mixed models is made, Algorithms are developed to compute the MLE's of the nonlinear effects and the covariance structures based on the penalized marginal likelihood. Convergence of the algorithms and selection of the smooth param¬eters are discussed.     

Quasi-maximum exponential likelihood estimation for a non stationary GARCH(1,1) model

ABSTRACT

This article investigates a quasi-maximum exponential likelihood estimator(QMELE) for a non stationary generalized autoregressive conditional heteroscedastic (GARCH(1,1)) model. Asymptotic normality of this estimator is derived under a non stationary condition. A simulation study and a real example are given to evaluate the performance of QMELE for this model.     

A nonparametric coherent confidence procedure

ABSTRACT

Holm's step-down testing procedure starts with the smallest p-value and sequentially screens larger p-values without any information on confidence intervals. This article changes the conventional step-down testing framework by presenting a nonparametric procedure that starts with the largest p-value and sequentially screens smaller p-values in a step-by-step manner to construct a set of simultaneous confidence sets. We use a partitioning approach to prove that the new procedure controls the simultaneous confidence level (thus strongly controlling the familywise error rate). Discernible features of the new stepwise procedure include consistency with individual inference, coherence, and confidence estimations for follow-up investigations. In a simple simulation study, the proposed procedure (treated as a testing procedure), is more powerful than Holm's procedure when the correlation coefficient is large, and vice versa when it is small. In the data analysis of a medical study, the new procedure is able to detect the efficacy of Aspirin as a cardiovascular prophylaxis in a nonparametric setting.     

Modeling of covariance structures of random effects and random errors in linear mixed models

Abstract

In this paper, we discuss how to model the mean and covariancestructures in linear mixed models (LMMs) simultaneously. We propose a data-driven method to modelcovariance structures of the random effects and random errors in the LMMs. Parameter estimation in the mean and covariances is considered by using EM algorithm, and standard errors of the parameter estimates are calculated through Louis’ (1982 Louis, T.A. (1982). Finding observed information using the EM algorithm. J. Royal Stat. Soc. B 44:98–130. [Google Scholar]) information principle. Kenward’s (1987 Kenward, M.G. (1987). A method for comparing profiles of repeated measurements. Appl. Stat. 36:296–308.[Crossref], [Web of Science ®] , [Google Scholar]) cattle data sets are analyzed for illustration,and comparison to the literature work is made through simulation studies. Our numerical analysis confirms the superiority of the proposed method to existing approaches in terms of Akaike information criterion.     

Risk minimization for an insurer with investment and reinsurance via g-expectation

Abstract

This paper is devoted to the study of a risk-based optimal investment and proportional reinsurance problem. The surplus process of the insurer and the risky asset process in the financial market are assumed to be general jump-diffusion processes. We use a convex risk measure generated by g-expectation to describe the risk of the terminal wealth with investment and reinsurance. Under the aim of minimizing the risk, the problem is solved by using techniques of stochastic maximum principles. Two interesting special cases are studied and the explicit expressions for optimal strategies and corresponding minimal risks are derived.     

On the Use of Semi-folding in Regular Blocked Two-level Factorial Designs

In this article, we consider experimental situations where a blocked regular two-level fractional factorial initial design is used. We investigate the use of the semi-fold technique as a follow-up strategy for de-aliasing effects that are confounded in the initial design as well as an alternative method for constructing blocked fractional factorial designs. A construction method is suggested based on the full foldover technique and sufficient conditions are obtained when the semi-fold yields as many estimable effects as the full foldover.     

Local Linear Estimation of Second-order Jump-diffusion Model

In this article, we propose the local linear estimators of the drift coefficient and diffusion coefficient in the second-order jump-diffusion model. We also show the consistency and asymptotic normality of these estimators under mild conditions.     

The Modified Pulak and Al-Sultan's Model for Determining the Optimum Process Parameters

Economic selection of process parameters has been an important topic in modern statistical process control. The optimum process parameters setting have a major effect on the expected profit/cost per item. There are some concerns on the problem of setting process parameters. Boucher and Jafari (1991 Boucher , T. O. , Jafari , M. A. ( 1991 ). The optimum target value for single filling operations with quality sampling plans . J. Qual. Technol. 23 : 44 – 47 . [CSA] [Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) first considered the attribute single sampling plan applied in the selection of process target. Pulak and Al-Sultan (1996 Pulak , M. F. S. , Al-Sultan , K. S. ( 1996 ). The optimum targeting for a single filling operation with rectifying inspection . Omega 24 : 727 – 733 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] , [Google Scholar]) extended Boucher and Jafari's model and presented the rectifying inspection plan for determining the optimum process mean. In this article, we further propose a modified Pulak and Al-Sultan model for determining the optimum process mean and standard deviation under the rectifying inspection plan with the average outgoing quality limit (AOQL) protection. Taguchi's (1986 Taguchi , G. ( 1986 ). Introduction to Quality Engineering . Asian Productivity Organization . [Google Scholar]) symmetric quadratic quality loss function is adopted for evaluating the product quality. By solving the modified model, we can obtain the optimum process parameters with the maximum expected profit per item and the specified quality level can be reached.     

Regression Properties for Asymmetric Generalized Scale Mixtures of Multivariate Gaussian Variables

Analytical properties of regression and the variance–covariance matrix of asymmetric generalized scale mixture of multivariate Gaussian variables are presented. The analysis includes an in-depth analytical investigation of the first two conditional moments of the mixing variable. Exact computable expressions for the prediction and the conditional variance are presented for the generalized hyperbolic distribution using the inversion theorem for Fourier transforms. An application to financial log returns is demonstrated via the classical Euler approximation. The methodology is illustrated by analyzing the regression of intraday log returns for CISCO against the corresponding data from S&P 500.