Comparison of dichotomized and distributional approaches in rare event clinical trial design: a fixed Bayesian design

This research was motivated by our goal to design an efficient clinical trial to compare two doses of docosahexaenoic acid supplementation for reducing the rate of earliest preterm births (ePTB) and/or preterm births (PTB). Dichotomizing continuous gestational age (GA) data using a classic binomial distribution will result in a loss of information and reduced power. A distributional approach is an improved strategy to retain statistical power from the continuous distribution. However, appropriate distributions that fit the data properly, particularly in the tails, must be chosen, especially when the data are skewed. A recent study proposed a skew-normal method. We propose a three-component normal mixture model and introduce separate treatment effects at different components of GA. We evaluate operating characteristics of mixture model, beta-binomial model, and skew-normal model through simulation. We also apply these three methods to data from two completed clinical trials from the USA and Australia. Finite mixture models are shown to have favorable properties in PTB analysis but minimal benefit for ePTB analysis. Normal models on log-transformed data have the largest bias. Therefore we recommend finite mixture model for PTB study. Either finite mixture model or beta-binomial model is acceptable for ePTB study.     

Coparenting and nonresident fathers’ involvement with young children after a nonmarital birth

We use data from the Fragile Families and Child Wellbeing Study to investigate the association between coparenting quality and nonresident fathers' involvement with children over the first five years after a nonmarital birth. We find that about one year after a nonmarital birth, 48% of fathers are living away from their child, rising to 56% and then to 63% at three and five years, respectively Using structural equation models to estimate cross-lagged effects, we find that positive coparenting is a strong predictor of nonresident fathers' future involvement, whereas fathers' involvement is only a weak (but significant) predictor of future coparenting quality. The positive effect of coparenting quality on fathers' involvement is robust across several techniques designed to address unobserved heterogeneity and across different strategies for handling missing data. We conclude that parents' ability to work together in rearing their common child across households helps keep nonresident fathers connected to their children and that programs aimed at improving parents' ability to communicate may have benefits for children irrespective of whether the parents' romantic relationship remains intact.     

Effects of a Punitive Environment on Children's Executive Functioning: A Natural Experiment

Few studies have examined the influence of environmental factors on children's executive functioning (EF) performance. The present study examined the effects of a punitive vs. non‐punitive school environment on West African children's EF skills. Tasks included a ‘cool’ (relatively non‐affective) and ‘hot’ (relatively affective/motivational) version of three EF tasks: delay of gratification; gift delay; and dimensional change card sort. Children had more difficulties with the hot versions of the tasks than the cool versions, and older children outperformed younger children. After controlling for verbal ability (Peabody picture vocabulary test‐third edition), a consistent pattern of interaction between school and grade level emerged. Overall, kindergarten children in the punitive school performed no differently than their counterparts in the non‐punitive school. However, in grade 1, children in the punitive school performed significantly worse than their counterparts in the non‐punitive school. These results point to the need to consider interactions among discipline style, age, and internalization processes of self‐regulation to better understand environmental influences on EF development.     

Auditory Distress Signals Potentiate Attentional Bias to Fearful Faces: Evidence for Multimodal Facilitation of Spatial Attention by Emotion

Unimodal emotionally salient visual and auditory stimuli capture attention and have been found to do so cross-modally. However, little is known about the combined influences of auditory and visual threat cues on directing spatial attention. In particular, fearful facial expressions signal the presence of danger and capture attention. Yet, it is unknown whether human auditory distress signals that accompany fearful facial expressions potentiate their capture of attention. It was hypothesized that the capture of attention by fearful faces would be enhanced when co-presented with auditory distress signals. To test this hypothesis, we used a modified multimodal dot-probe task where fearful faces were paired with three sound categories: no sound control, non-distressing human vocalizations, and distressing human vocalizations. Fearful faces captured attention across all three sound conditions. In addition, this effect was potentiated when fearful faces were paired with auditory distress signals. The results provide initial evidence suggesting that emotional attention is facilitated by multisensory integration.     

Cross-national differences in work-nonwork conflict

The present study examines the level of work-nonwork conflict found in eight countries categorized by value dimensions of individualism/collectivism and masculinity/femininity. Results indicate that masculine/collectivist countries have the lowest level of work-nonwork conflict. In addition, it was found that in masculine/collectivist countries, the work role dominates over the nonwork role.     

Psychopathology in pathological gamblers seeking treatment

High rates of psychiatric symptoms have been reported in pathological gamblers. This study of psychiatric comorbidity in pathological gamblers is the first to use structured psychiatric interviews assessing DSM-III-R Axis I and II disorders. The Structured Clinical Interview for DSM III-R (SCID-P, SCID-II) was administered to 40 (25 male, 15 male) pathological gamblers seeking outpatient treatment in Minnesota for gambling, and 64 (41 male, 23 female) controls. High lifetime rates of Axis I (92%) but not Axis II (25%) psychopathology were found in pathological gamblers as compared to controls. No differences between male and female gamblers were found in rates of affective, substance use or personality disorders. Females had higher rates of anxiety disorders and histories of physical/sexual abuse. Possible associations between psychiatric disorders and pathological gambling are discussed along with gambler typologies and implications for future research.The authors wish to gratefully acknowledge the assistance of: Gary Christenson, M.D., Carol Peterson, Ph.D., William Meller, M.D., Thomas Mackenzie, M.D.     

The epidemiology of physical attack and rape among crack-using women

This prospective study examines the epidemiology of physical attack and rape among a sample of 171 not-in-treatment, crack-cocaine using women. Since initiating crack use, 62% of the women reported suffering a physical attack. The annual rate of victimization by physical attack was 45%. Overall, more than half of the victims sought medical care subsequent to an attack. The prevalence of rape since crack use was initiated was 32%, and the annual rate was 11%. Among those women having been raped since they initiated crack use, 83% reported they were high on crack when the crime occurred as were an estimated 57% of the perpetrators. Logistic regression analyses showed that duration of crack use, arrest for prostitution, and some college education were predictors of having experienced a physical attack. Duration of crack use and a history of prostitution were predictors of suffering a rape. Drug abuse treatment programs must be sensitive to high levels of violence victimization experienced by crack-cocaine using women. Screening women for victimization, and treating the problems that emanate from it, may help make drug abuse treatment more effective.     

Deviations From Desired Age at Marriage: Mental Health Differences Across Marital Status

Although several factors condition mental health differences between married and never‐married adults, given recent increases in marriage delay and permanent singlehood, one modifying factor—deviation from desired age at marriage—has yet to be examined. Using data from the National Longitudinal Survey of Youth 1979 (N = 7,277), the author tested whether deviation from desired age at marriage shapes the mental health of married and never‐married adults as well as mental health differences between them. The results showed that most respondents failed to meet their initial preference for age at marriage. Marrying both earlier and later than desired (compared to on time) resulted in poorer mental health and fewer benefits compared to never marrying. For the never‐married, mental health was best, and differences compared to the married were nonsignificant, for those nearest their desired age at marriage. As timing deviations increased, however, a mental health deficit among the never‐married emerged.     

The North American Career Development Partnership: Experiment in International Collaboration

This article describes how career development programs became the focus of an international partnership between the United States and Canada. Beginning in 1976 in the United States, the National Occupational Information Coordinating Committee (NOICC) and its State Occupational Information Coordinating Committees (SOICCs) developed training and materials that promote the use of occupational and labor market information. Similarly, in the early 1970s, Canada began to explore the feasibility of creating a computer‐based career information delivery system. What follows is the story of an unusual and significant international collaboration. It concludes with identification of lessons learned.     

Editorial: Public thanks to reviewers

Population Research and Policy Review -