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61.
现有文献表明:城市间住宅价格的波动既相对独立又相互关联,主要体现为无关、中心城市领导和外围城市推动三种关系类型.利用1999年第1季度至2007年第4季度相关城市的住宅交易价格指数,利用协整理论和格兰杰因果检验对长三角和京津冀地区城市间的住宅价格关系进行实证检验.结果表明:上海是长三角地区住宅价格波动的领导城市,而北京的住宅价格则处于孤立的波动状态中;差异产生于城市间的经济关联度、消费者预期、投资组合策略以及对外部冲击反应时间等因素的综合作用.  相似文献   
62.
Summary.  We present a new class of methods for high dimensional non-parametric regression and classification called sparse additive models. Our methods combine ideas from sparse linear modelling and additive non-parametric regression. We derive an algorithm for fitting the models that is practical and effective even when the number of covariates is larger than the sample size. Sparse additive models are essentially a functional version of the grouped lasso of Yuan and Lin. They are also closely related to the COSSO model of Lin and Zhang but decouple smoothing and sparsity, enabling the use of arbitrary non-parametric smoothers. We give an analysis of the theoretical properties of sparse additive models and present empirical results on synthetic and real data, showing that they can be effective in fitting sparse non-parametric models in high dimensional data.  相似文献   
63.
We propose a phase I clinical trial design that seeks to determine the cumulative safety of a series of administrations of a fixed dose of an investigational agent. In contrast with traditional phase I trials that are designed solely to find the maximum tolerated dose of the agent, our design instead identifies a maximum tolerated schedule that includes a maximum tolerated dose as well as a vector of recommended administration times. Our model is based on a non-mixture cure model that constrains the probability of dose limiting toxicity for all patients to increase monotonically with both dose and the number of administrations received. We assume a specific parametric hazard function for each administration and compute the total hazard of dose limiting toxicity for a schedule as a sum of individual administration hazards. Throughout a variety of settings motivated by an actual study in allogeneic bone marrow transplant recipients, we demonstrate that our approach has excellent operating characteristics and performs as well as the only other currently published design for schedule finding studies. We also present arguments for the preference of our non-mixture cure model over the existing model.  相似文献   
64.
The equality of ordinary least squares estimator (OLSE), best linear unbiased estimator (BLUE) and best linear unbiased predictor (BLUP) in the general linear model with new observations is investigated through matrix rank method, some new necessary and sufficient conditions are given.  相似文献   
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In this paper, the generalized varying-coefficient single-index model is discussed based on penalized likelihood. All the unknown functions are fitted by penalized spline. The estimates of the unknown parameters and the unknown coefficient functions are obtained and the estimation approach is rapid and computationally stable. Under some mild conditions, the consistency and the asymptotic normality of these resulting estimators are given. Two simulation studies are carried out to illustrate the performance of the estimates. An application of the model to the Hong Kong environmental data further demonstrates the potential of the proposed modelling procedures.  相似文献   
68.
The empirical likelihood (EL) technique has been well addressed in both the theoretical and applied literature in the context of powerful nonparametric statistical methods for testing and interval estimations. A nonparametric version of Wilks theorem (Wilks, 1938 Wilks , S. S. ( 1938 ). The large-sample distribution of the likelihood ratio for testing composite hypotheses . Annals of Mathematical Statistics 9 : 6062 .[Crossref] [Google Scholar]) can usually provide an asymptotic evaluation of the Type I error of EL ratio-type tests. In this article, we examine the performance of this asymptotic result when the EL is based on finite samples that are from various distributions. In the context of the Type I error control, we show that the classical EL procedure and the Student's t-test have asymptotically a similar structure. Thus, we conclude that modifications of t-type tests can be adopted to improve the EL ratio test. We propose the application of the Chen (1995 Chen , L. ( 1995 ). Testing the mean of skewed distributions . Journal of the American Statistical Association 90 : 767772 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]) t-test modification to the EL ratio test. We display that the Chen approach leads to a location change of observed data whereas the classical Bartlett method is known to be a scale correction of the data distribution. Finally, we modify the EL ratio test via both the Chen and Bartlett corrections. We support our argument with theoretical proofs as well as a Monte Carlo study. A real data example studies the proposed approach in practice.  相似文献   
69.
For a segmented regression system with an unknown changepoint over two domains of a predictor, a new empirical likelihood ratio statistic is proposed to test the null hypothesis of no change. Under the null hypothesis of no change, the proposed test statistic is shown empirically to be Gumbel distributed with robust location and scale estimators against various parameter settings and error distributions. A power analysis is conducted to illustrate the performance of the test. Under the alternative hypothesis with a changepoint, the test statistic is utilized to estimate the changepoint between the two domains. A comparison of the frequency distributions between the proposed estimator and two parametric methods indicates that the proposed method is effective in capturing the true changepoint.  相似文献   
70.
In this article, we develop a model to study treatment, period, carryover, and other applicable effects in a crossover design with a time-to-event response variable. Because time-to-event outcomes on different treatment regimens within the crossover design are correlated for an individual, we adopt a proportional hazards frailty model. If the frailty is assumed to have a gamma distribution, and the hazard rates are piecewise constant, then the likelihood function can be determined via closed-form expressions. We illustrate the methodology via an application to a data set from an asthma clinical trial and run simulations that investigate sensitivity of the model to data generated from different distributions.  相似文献   
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