Semiparametric inference on the absolute risk reduction and the restricted mean survival difference

For time-to-event data, when the hazards are non-proportional, in addition to the hazard ratio, the absolute risk reduction and the restricted mean survival difference can be used to describe the time-dependent treatment effect. The absolute risk reduction measures the direct impact of the treatment on event rate or survival, and the restricted mean survival difference provides a way to evaluate the cumulative treatment effect. However, in the literature, available methods are limited for flexibly estimating these measures and making inference on them. In this article, point estimates, pointwise confidence intervals and simultaneous confidence bands of the absolute risk reduction and the restricted mean survival difference are established under a semiparametric model that can be used in a sufficiently wide range of applications. These methods are motivated by and illustrated for data from the Women’s Health Initiative estrogen plus progestin clinical trial.     

A detection algorithm for the first jump time in sample trajectories of jump-diffusions driven by α-stable white noise

Abstract

The purpose of this paper is to develop a detection algorithm for the first jump point in sampling trajectories of jump-diffusions which are described as solutions of stochastic differential equations driven by α-stable white noise. This is done by a multivariate Lagrange interpolation approach. To this end, we utilize computer simulation algorithm in MATLAB to visualize the sampling trajectories of the jump-diffusions for various combinations of parameters arising in the modeling structure of stochastic differential equations.     

Adaptive Lasso Variable Selection for the Accelerated Failure Models

This article considers the adaptive lasso procedure for the accelerated failure time model with multiple covariates based on weighted least squares method, which uses Kaplan-Meier weights to account for censoring. The adaptive lasso method can complete the variable selection and model estimation simultaneously. Under some mild conditions, the estimator is shown to have sparse and oracle properties. We use Bayesian Information Criterion (BIC) for tuning parameter selection, and a bootstrap variance approach for standard error. Simulation studies and two real data examples are carried out to investigate the performance of the proposed method.     

The asymptotic distribution of a pivotal quantity for a capture-recapture model

A pivotal quantity for a capture-recapture model is introduced and used to construct an asymptotic confidence region for (ε,N), where ε is the capture efficiency and N is the population size. The true confidence levels of certain regions are obtained by simulation. Certain confidence regions for (ε,N) are drawn to show the size of the regions and to show how confidence limits for N depend on ε.     

Robust Confidence Intervals for the Bernoulli Parameter

Despite the simplicity of the Bernoulli process, developing good confidence interval procedures for its parameter—the probability of success p—is deceptively difficult. The binary data yield a discrete number of successes from a discrete number of trials, n. This discreteness results in actual coverage probabilities that oscillate with the n for fixed values of p (and with p for fixed n). Moreover, this oscillation necessitates a large sample size to guarantee a good coverage probability when p is close to 0 or 1.

It is well known that the Wilson procedure is superior to many existing procedures because it is less sensitive to p than any other procedures, therefore it is less costly. The procedures proposed in this article work as well as the Wilson procedure when 0.1 ≤p ≤ 0.9, and are even less sensitive (i.e., more robust) than the Wilson procedure when p is close to 0 or 1. Specifically, when the nominal coverage probability is 0.95, the Wilson procedure requires a sample size 1, 021 to guarantee that the coverage probabilities stay above 0.92 for any 0.001 ≤ min {p, 1 ?p} <0.01. By contrast, our procedures guarantee the same coverage probabilities but only need a sample size 177 without increasing either the expected interval width or the standard deviation of the interval width.     

Bayesian Approaches to Nonparametric Estimation of Densities on the Unit Interval

This paper investigates nonparametric estimation of density on [0, 1]. The kernel estimator of density on [0, 1] has been found to be sensitive to both bandwidth and kernel. This paper proposes a unified Bayesian framework for choosing both the bandwidth and kernel function. In a simulation study, the Bayesian bandwidth estimator performed better than others, and kernel estimators were sensitive to the choice of the kernel and the shapes of the population densities on [0, 1]. The simulation and empirical results demonstrate that the methods proposed in this paper can improve the way the probability densities on [0, 1] are presently estimated.     

A Bayesian discovery procedure

Summary.  We discuss a Bayesian discovery procedure for multiple-comparison problems. We show that, under a coherent decision theoretic framework, a loss function combining true positive and false positive counts leads to a decision rule that is based on a threshold of the posterior probability of the alternative. Under a semiparametric model for the data, we show that the Bayes rule can be approximated by the optimal discovery procedure, which was recently introduced by Storey. Improving the approximation leads us to a Bayesian discovery procedure, which exploits the multiple shrinkage in clusters that are implied by the assumed non-parametric model. We compare the Bayesian discovery procedure and the optimal discovery procedure estimates in a simple simulation study and in an assessment of differential gene expression based on microarray data from tumour samples. We extend the setting of the optimal discovery procedure by discussing modifications of the loss function that lead to different single-thresholding statistics. Finally, we provide an application of the previous arguments to dependent (spatial) data.     

不确定条件下的企业边界战略

企业边界是由交易不确定性和技术不确定性相向变动决定的.美国和日本汽车制造企业的边界战略案例证明了不确定条件下企业边界战略的重要作用.制定边界战略要结合内部资源和创新类型,实践中需要对不确定性程度进行评价分类、确定行动以及动态管理.     

管理运筹学课程教学改革“ 3+ 2”模式研究

文章从管理运筹学教学特征出发,针对学生运筹思维能力、实际应用能力和实际操作能力的培养和提高,提出了"3+2"教学模式.研究了实用案例教学法、趣味教学法、计算机"伴侣"教学法这3种教学方法以及布置作业与认真批改的2种教学控制手段.并将为经济管理类管理运筹学教学改革提供思路.     

注塑制品残余应力的分析与计算

注塑制品已广泛应用于生活、生产等各个方面，注塑制品的残余应力是决定制品形状、表面质量、使用性能的主要因素。注塑制品的残余应力有两个来源：一个是流动残余应力。一个是热残余应力。结合熔体在注塑过程中的粘弹性变化特点。分析了注塑制品残余应力的产生原因和影响因素，给出了残余应力的计算方法。研究残余应力的产生机理对改善成型加工工艺条件、提高产品质量、降低废品率具有重要意义。