Maximum likelihood estimation of variance components in a completely random bib design

ABSTRACT

The purposes of this paper are to abstract from a number of articles variance component estimation procedures which can be used for completely random balanced incomplete block designs, to develop an iterated least squares (ITLS) computing algorithm for calculating maximum likelihood estimates, and to compare these procedures by use of simulated experiments. Based on the simulated experiments, the estimated mean square errors of the ITLS estimates are generally less than*those for previously proposed analysis of variance and symmetric sums estimators.     

Social Development in Hong Kong: Development Issues Identified by Social Development Index (SDI)

Surviving the aftermaths of the Asian Financial Crisis and SARS in 2003, Hong Kong’s economy has re-gained its momentum and its economic growth has been quite remarkable too in recent few years. Nevertheless, as reflected by the Social Development Index (SDI), economic growth in Hong Kong does not seem to have benefited the people of the city at large as we see social qualities such as cohesion, security, equity, and empowerment are gradually eroded. This paper aims to summarize the current state of social development in Hong Kong based on the SDI-2008 and identify the major social, political and economic challenges that are confronted by Hong Kong. Based on the findings, a range of policy options proposed for promoting a more balanced approach to social and economic development are discussed. The article illustrates the utility of social indicators research such as the SDI in assessing quality of life and assisting related social planning initiatives in Asian communities such as Hong Kong.     

Prediction based classification for longitudinal biomarkers

Assessment of circulating CD4 count change over time in HIV-infected subjects on antiretroviral therapy (ART) is a central component of disease monitoring. The increasing number of HIV-infected subjects starting therapy and the limited capacity to support CD4 count testing within resource-limited settings have fueled interest in identifying correlates of CD4 count change such as total lymphocyte count, among others. The application of modeling techniques will be essential to this endeavor due to the typically non-linear CD4 trajectory over time and the multiple input variables necessary for capturing CD4 variability. We propose a prediction based classification approach that involves first stage modeling and subsequent classification based on clinically meaningful thresholds. This approach draws on existing analytical methods described in the receiver operating characteristic curve literature while presenting an extension for handling a continuous outcome. Application of this method to an independent test sample results in greater than 98% positive predictive value for CD4 count change. The prediction algorithm is derived based on a cohort of n = 270 HIV-1 infected individuals from the Royal Free Hospital, London who were followed for up to three years from initiation of ART. A test sample comprised of n = 72 individuals from Philadelphia and followed for a similar length of time is used for validation. Results suggest that this approach may be a useful tool for prioritizing limited laboratory resources for CD4 testing after subjects start antiretroviral therapy.     

The Problem of Gender Identification in Conditions of Social Instability

Data from the Soviet period is compared with small-scale recent survey research in Chechnya. The author discusses legacy problems of female employment and empowerment in a society emphasizing patriarchal and Muslim values. She argues that outward appearances of religiosity, such as headscarves, do not necessarily equal inner faith. Distortions of gender identifications and social relationships are viewed as magnified in conditions of warfare and social upheaval.