Confidence interval estimation of the difference between paired AUCs based on combined biomarkers

In many diagnostic studies, multiple diagnostic tests are performed on each subject or multiple disease markers are available. Commonly, the information should be combined to improve the diagnostic accuracy. We consider the problem of comparing the discriminatory abilities between two groups of biomarkers. Specifically, this article focuses on confidence interval estimation of the difference between paired AUCs based on optimally combined markers under the assumption of multivariate normality. Simulation studies demonstrate that the proposed generalized variable approach provides confidence intervals with satisfying coverage probabilities at finite sample sizes. The proposed method can also easily provide P-values for hypothesis testing. Application to analysis of a subset of data from a study on coronary heart disease illustrates the utility of the method in practice.     

Least squares estimation of varying‐coefficient hazard regression with application to breast cancer dose‐intensity data

To enhance modeling flexibility, the authors propose a nonparametric hazard regression model, for which the ordinary and weighted least squares estimation and inference procedures are studied. The proposed model does not assume any parametric specifications on the covariate effects, which is suitable for exploring the nonlinear interactions between covariates, time and some exposure variable. The authors propose the local ordinary and weighted least squares estimators for the varying‐coefficient functions and establish the corresponding asymptotic normality properties. Simulation studies are conducted to empirically examine the finite‐sample performance of the new methods, and a real data example from a recent breast cancer study is used as an illustration. The Canadian Journal of Statistics 37: 659–674; 2009 © 2009 Statistical Society of Canada     

中国农村公共服务评价体系研究

农村公共服务水平低下和不平衡是导致城乡差距日益扩大的重要影响因素之一。本文试图构建农村公共服务发展状况评价指标体系,并基于2006年的数据进行实证研究,给出了研究结果的进一步分析评价。     

中美石油安全水平对经济增长影响的对比研究——基于灰色关联分析

为科学地评价比较中美石油安全水平对经济增长的影响程度,文章采用主成分分析方法,选取采储比水平、储量接替率、消费弹性系数、原油价格波动系数、对外依存度和石油占一次能源消费比重等6个要素指标,构成一个新的石油安全指标评价体系,并利用灰色关联方法比较分析了不同时间段内中美两国的石油安全水平与经济增长之间的关联度,得出自21世纪以来,美国经济发展对石油安全水平的依赖程度要远大于中国的结论。     

Nonparametric and semiparametric estimation of the three way receiver operating characteristic surface

In many situations the diagnostic decision is not limited to a binary choice. Binary statistical tools such as receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) need to be expanded to address three-category classification problem. Previous authors have suggest various ways to model the extension of AUC but not the ROC surface. Only simple parametric approaches are proposed for modeling the ROC measure under the assumption that test results all follow normal distributions. We study the estimation methods of three-dimensional ROC surfaces with nonparametric and semiparametric estimators. Asymptotical results are provided as a basis for statistical inference. Simulation studies are performed to assess the validity of our proposed methods in finite samples. We consider an Alzheimer's disease example from a clinical study in the US as an illustration. The nonparametric and semiparametric modelling approaches for the three way ROC analysis can be readily generalized to diagnostic problems with more than three classes.     

Shrinkage inverse regression estimation for model-free variable selection

Summary.  The family of inverse regression estimators that was recently proposed by Cook and Ni has proven effective in dimension reduction by transforming the high dimensional predictor vector to its low dimensional projections. We propose a general shrinkage estimation strategy for the entire inverse regression estimation family that is capable of simultaneous dimension reduction and variable selection. We demonstrate that the new estimators achieve consistency in variable selection without requiring any traditional model, meanwhile retaining the root n estimation consistency of the dimension reduction basis. We also show the effectiveness of the new estimators through both simulation and real data analysis.     

长三角科技资源配置能力与城市化进程的协调耦合关系研究

科技资源配置能力已成为长江地区城市化进程的重要推力。因此,在构建科技资源与城市化耦合系统评价指标体系的基础上,利用耦合协调度模型综合评价长江区域科技资源配置与城市化的交互耦合关系。结果显示:从时间维度看,研究期内长三角科技资源配置能力与城市化进程之间的耦合关系基本上处于磨合阶段,耦合协调度以低度协调耦合状态为主并逐步过渡到中度协调耦合状态;从空间维度看,长三角各城市的科技资源配置与城市化耦合协调度在极度协调耦合、高度协调耦合、中度协调耦合、低度协调耦合四个阶段均有分布,层级分明且大部分城市尚处于低度协调耦合状态。     

收入分布函数在收入不平等研究领域的应用

收入分布函数的研究对于收入不平等的探讨意义重大,但是国内该领域的研究尚待进一步的拓展。笔者在文献回顾的基础上梳理了国外的相关研究,把常用的分布函数分成两参数分布和多参数分布函数两类,介绍了各类函数拟合居民实际收入分布的效果及其与基尼系数的关系;同时,本文剖析了各类函数之间的内在联系;进一步,基于分布函数的角度,笔者研究了收入流动性与收入不平等之间的联系,分析了平均数和中位数比值与基尼系数之间的数学关系以及如何利用该比值来估计分布函数的参数。利用这些研究结果,文章探讨了2010年我国城镇居民的收入结构和贫困问题并提出了一些前瞻性的研究建议。     

Asymptotic convergence of dimension reduction based boosting in classification

In high dimensional classification problem, two stage method, reducing the dimension of predictor first and then applying the classification method, is a natural solution and has been widely used in many fields. The consistency of the two stage method is an important issue, since errors induced by dimension reduction method inevitably have impacts on the following classification method. As an effective method for classification problem, boosting has been widely used in practice. In this paper, we study the consistency of two stage method–dimension reduction based boosting algorithm (briefly DRB) for classification problem. Theoretical results show that Lipschitz condition on the base learner is required to guarantee the consistency of DRB. This theoretical findings provide useful guideline for application.     

Estimation with right‐censored observations under a semi‐Markov model

The semi‐Markov process often provides a better framework than the classical Markov process for the analysis of events with multiple states. The purpose of this paper is twofold. First, we show that in the presence of right censoring, when the right end‐point of the support of the censoring time is strictly less than the right end‐point of the support of the semi‐Markov kernel, the transition probability of the semi‐Markov process is nonidentifiable, and the estimators proposed in the literature are inconsistent in general. We derive the set of all attainable values for the transition probability based on the censored data, and we propose a nonparametric inference procedure for the transition probability using this set. Second, the conventional approach to constructing confidence bands is not applicable for the semi‐Markov kernel and the sojourn time distribution. We propose new perturbation resampling methods to construct these confidence bands. Different weights and transformations are explored in the construction. We use simulation to examine our proposals and illustrate them with hospitalization data from a recent cancer survivor study. The Canadian Journal of Statistics 41: 237–256; 2013 © 2013 Statistical Society of Canada