Significance of the Dermal Route of Exposure to Risk Assessment

The skin is a route of exposure that needs to be considered when conducting a risk assessment. It is necessary to identify the potential for dermal penetration by a chemical as well as to determine the overall importance of the dermal route of exposure as compared with inhalation or oral routes of exposure. The physical state of the chemical, vapor or liquid, the concentration, neat or dilute, and the vehicle, lipid or aqueous, is also important. Dermal risk is related to the product of the amounts of penetration and toxicity. Toxicity involves local effects on the skin itself and the potential for systemic effects. Dermal penetration is described in large part by the permeability constant. When permeability constants are not known, partition coefficients can be used to estimate a chemical's potential to permeate the skin. With these concepts in mind, a tiered approach is proposed for dermal risk assessment. A key first step is the determination of a skin-to-air or skin-to-medium partition coefficient to estimate a potential for dermal absorption. Building a physiologically-based pharmacokinetic (PBPK) model is another step in the tiered approach and is useful prior to classical in vivo toxicity tests. A PBPK model can be used to determine a permeability constant for a chemical as well as to show the distribution of the chemical systemically. A detailed understanding of species differences in the structure and function of the skin and how they relate to differences in penetration rates is necessary in order to extrapolate animal data from PBPK models to the human. A study is in progress to examine anatomical differences for four species.     

An alternative to farmer age as an indicator of life-cycle stage: The case for a farm family age index

In studies of farming, the age of the principal decision-maker (PDM) has been associated with numerous farm structural and managerial features and has been widely accepted as a good indicator of the influence of life-cycle factors on decision-making. As such, it has become an important aspect of many quantitative studies of agricultural change. However, contemporary studies of family farming demonstrate that the concept of a single PDM in family farms is becoming an anachronism as alternative enterprises, pluriactivity and the scale of family farms force more diffuse management/operating systems. This raises questions concerning whether the age of the PDM can still be taken as representative of farm structure, strategy or life-cycle stage? Using a study conducted in the Grampian Mountains region of Scotland in 2003 this note investigates the impact of using an alternative index—compiled by averaging the age of family members working on the farm. It suggests that PDM age is a relatively poor indicator of farm structural and managerial features compared to a family age index and calls for researchers to think about alternative approaches to measuring ‘age’ as an indicator.     

Inside two commercially available statistical expert systems

A decade of research into the applications of artificial intelligence in statistics has finally resulted in the appearance of commercially available statistical expert systems. This paper takes a closer look at two of these systems, which are now commercially available on microcomputers, and shows what knowledge they actually contain and how they operate. It is concluded that although the technology and concepts that drive these systems could still benefit from further improvement, the real challenge lies in defining and constructing the statistical knowledge and strategy that should be incorporated and in presenting the results to the user's full advantage.     

A measure of slope-rotatability for second order response surface experimental designs

In the design of experiments for estimating the slope of a response surface, slope-rotatability is a desirable property. In this paper, a measure is introduced that enables us to assess the degree of slope-rotatability for a given response surface design. The measure takes the value zero if and only if the design is slope-rotatable, and becomes larger as the design deviates from a slope-rotatable design. Examples of applying this measure to some response surface designs are also given.     

An uncertain future: children of mentally ill parents.

Research reports the uncertain outcome of variables affecting the life of a child of an MI parent. Nurses must avoid stereotyping children before assessment; they are to be in the forefront in assessing self-care skills and deficits to guide planning individual interventions for children and MI parents. Long-term research theory-based interventions will enhance mental health in high-risk children and families.     

Pseudo–Modelling of Outliers for Estimation of Regression And Time Series Models

This paper documents situations where the variance inflation model for outliers has undesirable properties. The model is commonly used to accommodate outliers in a Bayesian analysis of regression and time series models. The alternative approach provided here does not suffer from these undesirable properties but gives inferences similar to those of the variance inflation model when this is appropriate. It can be used with regression, time series, and regression with correlated errors in a unified way, and adheres to the scientific principle that inference should be based on the data after obvious outliers have been discarded. Only one parameter is required for outliers; it is interpretable as the a priori willingness to remove observations from the analysis.     

Triadic Interaction among Newly Acquainted 2-year-olds

Are children as young as 2 years old able to interact in groups of three? The study applied the family triad model first introduced by Parke, Power, and Gottman (1979 ) to the case of peer interaction. In Experiment 1 , the model was refined for use in studies of peer interaction and applied to an existing dataset of 16 triads of newly acquainted 24‐month‐olds. In Experiment 2 , the triadic coding system was further refined and applied to 12 single‐sex triads of newly acquainted 2‐year‐olds. The findings demonstrated that 2‐year‐olds are capable of triadic interaction although the predominant interaction pattern in triads is still dyadic. Contrary to past reports, triadic interaction was more likely to occur when the children were not in conflict. Both girls and boys were capable of triadic interaction.     

Joint impact of multiple observations on a subset of variables in multiple linear regression

In multiple linear regression analysis, each observation affects the fitted regression equation differently and has varying influences on the regression coefficients of the different variables. Chatterjee & Hadi (1988) have proposed some measures such as DSSE_ij (Impact on Residual Sum of Squares of simultaneously omitting the ith observation and the jth variable), F_j (Partial F-test for the jth variable) and F_j(i) (Partial F-test for the jth variable omitting the ith observation) to show the joint impact and the interrelationship that exists among a variable and an observation. In this paper we have proposed more extended form of those measures DSSE_IJ, F_J and F_J(I) to deal with the interrelationships that exist among the multiple observations and a subset of variables by monitoring the effects of the simultaneous omission of multiple variables and multiple observations.