Statistical Properties of a Modified Accelerated Design for Phase I Cancer Clinical Trials

We consider the semiparametric profile likelihood inference for the distribution function under doubly censored data. For further developments of the statistical inference based on the profile likelihood ratio and alternative tools such as the score or Wald-type inference, we discuss the structures of the profile likelihood estimators and their derivatives included in the score function and the Fisher function of the profile likelihood, establishing the consistencies of their estimators.     

Robust Confidence Intervals for the Bernoulli Parameter

Despite the simplicity of the Bernoulli process, developing good confidence interval procedures for its parameter—the probability of success p—is deceptively difficult. The binary data yield a discrete number of successes from a discrete number of trials, n. This discreteness results in actual coverage probabilities that oscillate with the n for fixed values of p (and with p for fixed n). Moreover, this oscillation necessitates a large sample size to guarantee a good coverage probability when p is close to 0 or 1.

It is well known that the Wilson procedure is superior to many existing procedures because it is less sensitive to p than any other procedures, therefore it is less costly. The procedures proposed in this article work as well as the Wilson procedure when 0.1 ≤p ≤ 0.9, and are even less sensitive (i.e., more robust) than the Wilson procedure when p is close to 0 or 1. Specifically, when the nominal coverage probability is 0.95, the Wilson procedure requires a sample size 1, 021 to guarantee that the coverage probabilities stay above 0.92 for any 0.001 ≤ min {p, 1 ?p} <0.01. By contrast, our procedures guarantee the same coverage probabilities but only need a sample size 177 without increasing either the expected interval width or the standard deviation of the interval width.     

Estimation of parameters and reliability from generalized life models

Simultaneous estimation of parameters with p (≥ 2) components, where each component has a generalized life distribution, is considered under a sum of squared error loss function. Improved estimators are obtained which dominate the maximum likelihood and the niinimum mean square estimators. Robustness of the improved estimators is shown even when the component distributions are dependent. The result is extended to the estimation of the system reliability when the components are connected in series. Several numerical studies are performed to demonstrate the risk improvement and the Pitman closeness of the new estimators.     

Economic-statistical design of X ¥ charts for non-normal data by considering quality loss

When the X ¥ control chart is used to monitor a process, three parameters should be determined: the sample size, the sampling interval between successive samples, and the control limits of the chart. Duncan presented a cost model to determine the three parameters for an X ¥ chart. Alexander et al. combined Duncan's cost model with the Taguchi loss function to present a loss model for determining the three parameters. In this paper, the Burr distribution is employed to conduct the economic-statistical design of X ¥ charts for non-normal data. Alexander's loss model is used as the objective function, and the cumulative function of the Burr distribution is applied to derive the statistical constraints of the design. An example is presented to illustrate the solution procedure. From the results of the sensitivity analyses, we find that small values of the skewness coefficient have no significant effect on the optimal design; however, a larger value of skewness coefficient leads to a slightly larger sample size and sampling interval, as well as wider control limits. Meanwhile, an increase on the kurtosis coefficient results in an increase on the sample size and wider control limits.     

具有GARCH（1，1）-正态误差项的非对称单位根检验研究

摘　　要:理论研究表明许多经济变量呈现出非对称的门限自回归（TAR）或动态门限自回归（M-TAR）数据生成机制,因而非对称单位根检验就成为该领域的主要研究方向之一。本文对非对称单位根检验Enders-Granger方法在GARCH（1,1）-正态误差项下的检验水平与检验势作了系统的仿真研究。研究表明：GARCH（1,1）-正态误差项的TAR或M-TAR模型会对该方法的检验水平和检验势产生重要影响。     

Statistical Inference Based on Pooled Data: A Moment-Based Estimating Equation Approach

We consider statistical inference on parameters of a distribution when only pooled data are observed. A moment-based estimating equation approach is proposed to deal with situations where likelihood functions based on pooled data are difficult to work with. We outline the method to obtain estimates and test statistics of the parameters of interest in the general setting. We demonstrate the approach on the family of distributions generated by the Box-Cox transformation model, and, in the process, construct tests for goodness of fit based on the pooled data.     

Easy-to-construct confidence bands for comparing two simple linear regression lines

This paper shows how to construct confidence bands for the difference between two simple linear regression lines. These confidence bands provide directly the information on the magnitude of the difference between the regression lines over an interval of interest and, as a by-product, can be used as a formal test of the difference between the two regression lines. Various different shapes of confidence bands are illustrated, and particular attention is paid towards confidence bands whose construction only involves critical points from standard distributions so that they are consequently easy to construct.     

水蒸气钝化裂化催化剂工艺条件的探讨

对共Y-15裂化催化剂在模拟工业条件下进行了不同温度、压力和时间的水蒸气处理,考察了其钝化效果,将高温水蒸气的钝化效果与锑钝化剂的钝化效果进行了比较.结果表明,前者的钝化效果优于后者;经高温水蒸气钝化后的裂化催化剂能在微活性不显著降低的前提下,使氢气产率、焦炭产率显著降低.     

PES-C,(PP/Bis-T)PES的次级松驰与转变

描述了酚酞型聚芳醚砜(PES-C)的次级松驰和转变与其结构的关系.TBA和动态力学实验结果表明:PES-C及其共聚物(PP/Bis-T)PES分别在0～50℃和-100℃附近呈现出两个次级松驰峰;双酚T单元的引入导致了PES-C在0～50℃之间的次级松驰位置改变.证实了Cardo侧基的存在对-100℃的次级松驰有较大的贡献.