肥胖基因

肥胖症已经逐渐成为了一个严重的健康问题和社会问题 ,对肥胖症的研究已深入到分子水平。自肥胖基因被克隆以来 ,针对肥胖基因的结构、突变、表达及其产物的生物学作用已进行了大量的研究。本文就肥胖基因的发现和定位、结构和突变及其产物———瘦素的相关研究进行了综述 ,并指出了对肥胖基因进行深入研究的相关领域     

In Whose Backyard?: Concern About Siting a Nuclear Waste Facility*

Proponents of hazardous and nuclear waste depositories label opponents to local siting of such facilities “NIMBYs” (Not In My Backyard). This study assesses the extent to which the NIMBY label and the strategies of industry proponents to reduce opposition function on a reasonable set of assumptions. Using survey data and multiple regression techniques, the levels of concern of residents living in the county selected as the site of a low level radioactive waste disposal facility (imminent threat condition) are compared with a statewide sample (hypothetical threat condition). Consistent with proponents' theoretical assumptions, the levels of concern are greater for respondents under conditions of imminent threat than of hypothetical threat. However, within the host county, levels of concern are lowest, albeit most polarized, in the community closest to the proposed site. A conflict theory approach enhances an understanding of these findings by suggesting that within the most proximate community levels of concern are lowest for citizens who stand to gain the most economic benefits from the facility but highest for those citizens who are least likely to derive tangible gains.     

The Boston Area Diary Study and the Moral Citizenship of Care

This paper describes the theoretical foundations, empirical findings, and practical and philosophical implications of the Boston Area Diary Study (BADS), a study of the caring behavior of 44 participants over one calendar year. In particular, the paper presents an identification theory of care and discusses how it shaped the conceptualization, collection, and analysis of the data in a year-long diary study of daily voluntary assistance. The findings from the BADS (1) theoretically confirm the identification theory of care; (2) methodologically capture how individuals perceive and carry out caring behavior as a unity; and (3rpar; empirically document the existence of a moral citizenship in America that is substantially more vigorous than is implied by the usual indicators of civic and political citizenship.     

Self-defense training for college women.

This article explores the effectiveness of self-defense training for college women. Advocates of self-defense training believe these courses will not only provide women with the physical survival techniques necessary to repel attacks effectively, but that this kind of training will also help to prevent future violence by developing traits such as assertiveness and confidence in individuals. There is evidence that women who convey such characteristics are less likely to be victimized. Opponents argue that self-defense training does not properly prepare women for an attack, does not adequately address acquaintance rape threats, and can provide a dangerous false sense of security to students. This article reviews the relevant literature, outlines practical suggestions for initiatives in this area, and describes a model self-defense course at one university. Guidelines for evaluation and implications for university policy and program decisions that address violence against women on college campuses are included.     

Enabling a Powerful Marine and Offshore Decision-Support Solution Through Bayesian Network Technique

A powerful practical solution is by far the most desired output when making decisions under the realm of uncertainty on any safety-critical marine or offshore units and their systems. With data and information typically being obtained incrementally, adopting Bayesian network (BN) is shown to realistically deal with the random uncertainties while at the same time making risk assessments easier to build and to check. A well-matched methodology is proposed to formalize the reasoning in which the focal mechanism of inference processing relies on the sound Bayes's rule/theorem that permits the logic. Expanding one or more influencing nodal parameters with decision and utility node(s) also yields an influence diagram (ID). BN and ID feasibility is shown in a marine evacuation scenario and that of authorized vessels to floating, production, storage, and offloading collision, developed via a commercial computer tool. Sensitivity analysis and validation of the produced results are also presented.     

Testing regression lack of fit without replication: a tutorial around Minitab's XLOF procedures

The tutorial is concerned with two types of test for the general lack of fit of a linear regression model, as found in the Minitab software package, and which do not require replicated observations. They aim to identify non-specified curvature and interaction in predictors, by comparing fits over the predictor region divided into two parts. Minitab's regression subcommand XLOF which gives the tests is only briefly documented in the manual and, unlike virtually all other statistical procedures in the software, it is not standard and cannot be readily found in textbooks. The two types of test are described here; they concern the predictors one-at-a-time and the predictors all-at-once. An example of their use is given. A suite of macros is available which reproduces the results of the XLOF tests in much more detail than is given by the XLOF subcommand.     

AN ALGORITHM FOR THE CONSTRUCTION OF OPTIMAL OR NEAR-OPTIMAL CHANGE-OVER DESIGNS

This paper presents an algorithm for the construction of optimal or near optimal change-over designs for arbitrary numbers of treatments, periods and units. Previous research on optimality has been either theoretical or has resulted in limited tabulations of small optimal designs. The algorithm consists of a number of steps:first find an optimal direct treatment effects design, ignoring residual effects, and then optimise this class of designs with respect to residual effects. Poor designs are avoided by judicious application of the (M, S)-optimality criterion, and modifications of it, to appropriate matrices. The performance of the algorithm is illustrated by examples.     

The impact of unionization,right-to-work laws,and female labor force participation on earnings inequality across states

This study examines the effect of unionization, right-to-work laws, and participation of women in the labor force on income inequality. Two distinct models are developed using 1970 and 1980 census data on the 50 states in the U.S. First, an income inequality model is specified as a beta distribution of the second kind to estimate Gini measures of income inequality. Second, these Gini estimates are used in a simultaneous equations model. The 1970 results indicate that higher unionization rates decreased inequality while right-to-work laws increased inequality. In 1980, the measure of inequality was lower in states with higher female labor force participation. We thank an unknown referee and the editor for comments and criticisms that greatly improved the paper. The usual caveat applies.