Analysis of a factorial quantal response assay using inverse regression

An inverse regression approach to analyzing quantal response assays with one quanritative independent- variable and any number of qualitative independent variables is presented. A general factorial model ror LQC- inverted relationship and methods of testing hypotheses estimating qulitative Interest are developed. This naper provides a modified method of analysis which is easier to apply than previously existing methods.     

Exact and approximate distributions for linear contrasts of means and variances

A Bayesian analysis is presented for the K-group Behrens-Fisher problem. Both exact posterior distributions and approximations were developed for both a general linear contrast of the K means and the K variances, given either proper diffuse or informative conjugate priors. The contrast of variances is a unique feature of the heterogeneous variance model that enables investigators to test specific effects of experimental manipulations on variance. Finally, important-differences were observed between the heterogeneous variance model and the homogeneous model.     

Multicollinearity and the value of a priori information

A measure of multicollinearity is defined which is useful in evaluating maintained hypotheses and aiding estimator selection as it suggests when a non-traditional estimator proposed by Bock (1975) is minimax and dominates ordinary least squares. An example is used to illustrate the presented methodology.     

How non-normality affects the quadratic discriminant function

The quadratic discriminant function is commonly used for the two group classification problem when the covariance matrices in the two populations are substantially unequal. This procedure is optimal when both populations are multivariate normal with known means and covariance matrices. This study examined the robustness of the QDF to non-normality. Sampling experiments were conducted to estimate expected actual error rates for the QDF when sampling from a variety of non-normal distributions. Results indicated that the QDF was robust to non-normality except when the distributions were highly skewed, in which case relatively large deviations from optimal were observed. In all cases studied the average probabilities of misclassification were relatively stable while the individual population error rates exhibited considerable variability.     

Statistical techniques in stereology

Stereology typically concerns estimation of properties of a geometric structure from plane section information. This paperprovides a brief review of some statistical aspects of this rapidly developing field, with some reference to applications in the earth sciences. After an introductory discussion of the scope of stereology, section 2 briefly mentions results applicable when no assumptions can be made about the stochastic nature of the sampled matrix, statistical considerations then arising solelyfrom the ‘randomness’ of the plane section. The next two sections postulate embedded particles of specific shapes, the particular case of spheres being discussed in some detail.

References are made to results for ‘thin slices’ and other prob-ing mechanisms. Randomly located convex particles, of otherwise arbitrary shape, are discussed in section 5 and the review concludes with a specific application of stereological ideas to some data on neolithic mining.     

Univaiuate anu multivariate categorical data analysis for block designs

Analysis for univariate and multivariate categorical data in block designs is given and illustrated through examples. The univariate analysis compares the treatments on the basis of their pooled frequency distributions (pooled over blocks). The test statistic used is called Q after Cochran (1950). The large sample null distribution of Q is a chi-square. Analysis of p-variate categorical data (kth variable having ck classes, K=1,...,p) can be done by treating it as a univariate categorical problem with [d] classes. Very often [d] is large in relation to the size of the experiment. This makes the expected frequencies for some of the cells very small, making the univariate method inapplicable. In these circumstances it may be reasonable to compare the treatments on the basis of marginal distributions up to the mth dimension, 1[d] , which is given in this paper. This method is also illustrated for missing observations     

Time series analysis of stratospheric ozone

Time series analyses of monthly average total ozone measured at 37 stations throughout the world were used to estimate the extent to which the average ozone trend correlates with the depletion curve hypothesized as due to chlorofluorocarbons (CFCs). Statistical characteristics of stations in the ensemble were used to help define appropriate model and station selection criteria. The maximum likelihood procedure developed herein estimates the weighted average trend, its. variance, and the intra- and inter-station variance components of the trend. Correlations among trends at different stations are also taken into account. The models were subjected to much checking and criticism. Variations in statistical methodology are used to show that the results are insensitive to details of the model selection criteria. The method does not discriminate well between the hypothesized CFC trend and a linear trend. The trend estimates represent the sum of all long-term global effects. The variance includes all effects that differ from station-to-station. The estimated trend and 2α limits for 14 stations with 20-year records (1958-79) is an ozone increase through 1979 of (1.5+1.0) percent. At the 23 stations with shorter records, the trend is (1.0=1.7) percent. It is concluded that no significant depletion in stratospheric ozone has occurred from any cause through the end of 1979.     

Unbiased F Tests for Factorial Experiments for Correlated Data

This paper finds a general form of the correlation matrix that may be used to provide unbiased F tests in a.k-way factorial experiment.     

Smooth goodness of fit tests for the weibull distribution with singly censored data

The smooth goodness of fit tests are generalized to singly censored data and applied to the problem of testing Weibull (or extreme value) fit. Smooth tests, Pearson-type tests, and the spacings tests proposed by Mann, Schemer, and Fertig (1973) are compared on the basis of local asymptotic relative efficiency with respect to the asymptotic best test against generalized gamma alternatives, The smooth test of order one Is found to be most efficient for the generalized gamma alternatives.