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941.
We consider two related aspects of the study of old‐age mortality. One is the estimation of a parameterized hazard function from grouped data, and the other is its possible deceleration at extreme old age owing to heterogeneity described by a mixture of distinct sub‐populations. The first is treated by half of a logistic transform, which is known to be free of discretization bias at older ages, and also preserves the increasing slope of the log hazard in the Gompertz case. It is assumed that data are available in the form published by official statistical agencies, that is, as aggregated frequencies in discrete time. Local polynomial modelling and weighted least squares are applied to cause‐of‐death mortality counts. The second, related, problem is to discover what conditions are necessary for population mortality to exhibit deceleration for a mixture of Gompertz sub‐populations. The general problem remains open but, in the case of three groups, we demonstrate that heterogeneity may be such that it is possible for a population to show decelerating mortality and then return to a Gompertz‐like increase at a later age. This implies that there are situations, depending on the extent of heterogeneity, in which there is at least one age interval in which the hazard function decreases before increasing again.  相似文献   
942.
This paper considers estimation and prediction in the Aalen additive hazards model in the case where the covariate vector is high-dimensional such as gene expression measurements. Some form of dimension reduction of the covariate space is needed to obtain useful statistical analyses. We study the partial least squares regression method. It turns out that it is naturally adapted to this setting via the so-called Krylov sequence. The resulting PLS estimator is shown to be consistent provided that the number of terms included is taken to be equal to the number of relevant components in the regression model. A standard PLS algorithm can also be constructed, but it turns out that the resulting predictor can only be related to the original covariates via time-dependent coefficients. The methods are applied to a breast cancer data set with gene expression recordings and to the well known primary biliary cirrhosis clinical data.  相似文献   
943.
We proposed a modification to the variant of link-tracing sampling suggested by Félix-Medina and Thompson [M.H. Félix-Medina, S.K. Thompson, Combining cluster sampling and link-tracing sampling to estimate the size of hidden populations, Journal of Official Statistics 20 (2004) 19–38] that allows the researcher to have certain control of the final sample size, precision of the estimates or other characteristics of the sample that the researcher is interested in controlling. We achieve this goal by selecting an initial sequential sample of sites instead of an initial simple random sample of sites as those authors suggested. We estimate the population size by means of the maximum likelihood estimators suggested by the above-mentioned authors or by the Bayesian estimators proposed by Félix-Medina and Monjardin [M.H. Félix-Medina, P.E. Monjardin, Combining link-tracing sampling and cluster sampling to estimate the size of hidden populations: A Bayesian-assisted approach, Survey Methodology 32 (2006) 187–195]. Variances are estimated by means of jackknife and bootstrap estimators as well as by the delta estimators proposed in the two above-mentioned papers. Interval estimates of the population size are obtained by means of Wald and bootstrap confidence intervals. The results of an exploratory simulation study indicate good performance of the proposed sampling strategy.  相似文献   
944.
Total fertility rates fell to previously unseen levels in a large number of countries beginning in the early 1990s. The persistence of TFRs below 1.3 raised the possibility of rapid population aging and decline. We discuss the recent widespread turnaround in so‐called lowest‐low‐fertility countries in Europe and East Asia. The number of countries with TFRs below 1.3 fell from 21 in 2003 to five in 2008. Moreover, the upturn in the TFR was not confined to lowest‐fertility countries, but affected the whole developed world. We explore the demographic explanations for the recent rise in TFRs stemming from fertility timing effects as well as economic, policy, and social factors. Although the current economic downturn may suppress TFRs in the short run, we conclude that formerly lowest‐low‐fertility countries will continue to see increases in fertility as the transitory effects of shifts to later childbearing become less important.  相似文献   
945.
Based on a sample of older workers from the Maastricht Cohort Study, the authors investigate the prevalence and dynamics of self‐reported under‐skilling and its effects on workers' need for recovery, their risk of losing employment and their retirement intentions over a two‐year period. They find that being under‐skilled is associated both with higher levels of need for recovery over time and with the risk of losing employment, but not with early retirement intentions. To achieve sustainable employment, they argue, the course of under‐skilling should be monitored throughout workers' careers, enabling timely interventions to avoid its negative consequences.  相似文献   
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Contemporary global issues can be examined through the lens of modern photographic art. In an effort to prepare global-ready graduates, this article explores the pressing problems of environmental degradation, urbanization, and homelessness through the work of three contemporary artists. Illustrative works, suggested approaches, and curriculum resources are provided.  相似文献   
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