Drug resistance in an age-of-infection model

ABSTRACT

In the case of a disease spreading over a time-scale comparable to the average lifetime in a host population, when the infectiousness of individuals depends on the tine since the onset of infection and when infections involve both drug-sensitive and drug-resistant strains of a pathogen, resistance may develop during the treatment of drug-sensitive strains. If increasing the treatment rate reduces the reproduction number of the drug-sensitive strain to a value below the reproduction number of the drug-resistant strain, then the disease may persist at a boundary equilibrium where only drug-resistant infection is present.     

财富创造者的伦理尊严

财富创造者的伦理尊严是人类伦理尊严的一种重要表现形式,它是指一个人以合乎财富伦理的方式创造了真正有利于人类生存和发展的物质财富或精神财富而因此得到道德上的肯定、称赞和尊重。人类社会往往借助于两个途径来维护财富创造者的伦理尊严,即个人的良好道德修养和社会制度的合理设计和安排。     

Local composite quantile regression estimation of time-varying parameter vector for multidimensional time-inhomogeneous diffusion models

This paper is dedicated to the study of the composite quantile regression (CQR) estimations of time-varying parameter vectors for multidimensional diffusion models. Based on the local linear fitting for parameter vectors, we propose the local linear CQR estimations of the drift parameter vectors, and verify their asymptotic biases, asymptotic variances and asymptotic normality. Moreover, we discuss the asymptotic relative efficiency (ARE) of the local linear CQR estimations with respect to the local linear least-squares estimations. We obtain that the local estimations that we proposed are much more efficient than the local linear least-squares estimations. Simulation studies are constructed to show the performance of the estimations proposed.     

网络语境下的大学生榜样教育研

互联网的广泛应用使大学生榜样教育在形式上和内容上都得到了丰富和深化，但仍然存在网络推广方式还不能适应大学生成长要求、传统榜样的影响正在弱化等问题。运用问卷调查法，分析了当前网络语境下大学生榜样教育的现状以及存在的问题，剖析了榜样教育弱化的原因，进而提出了适合网络语境下的大学生榜样教育路径。     

社会正义的实现:从“排斥冶走向“包容性政策冶

我国社会政策经历过一个建构与重构的过程,但排斥性是一以贯之的主基调.随着人类从工业社会逐步迈入后工业社会,基于差异承认与平等实现而形成的二维正义观登场.而现行社会政策既无法体现对差异的尊重,也无法保证平等实现,从而呈现出对正义的偏离.只有建立起包容性社会政策,尊重个体差异,同时保证多元主体享有共同福利的机会和水平,才能实现正义.     

利用数学软件复原碎纸片的方法

研究了碎纸片的拼接复原问题,建立了合理有效的碎纸片拼接复原的数学模型；给出了数学软件实现自动拼接的具体算法；结合人工拼接得出复原图片；最后,对所给的拼接方法提出了改进方向.     

美国GEPI伤残标准之争议

《永久性残损评定指南》(Guides to the Evaluation of Permanent Impairment,GEPI)是当今美国司法实践中广泛使用的伤残评定标准,虽然历经修订,GEPI在司法实践中仍然存在诸多争议.针对GEPI在美国司法实践中的应用情况,从评定合法性、评定人资质、评定有效性和可靠性,以及评定全面性等方面,对GEPI的实践问题进行分析,以期为我国伤残评定体系的构建提供借鉴和依据.     

胡塞尔“构造”概念的三种图式

“构造”概念是胡塞尔现象学的核心概念，它被用来刻画意义如何向我们显现。索科拉夫斯基认为，胡塞尔分别在静态现象学和发生现象学阶段采取了“静态构造”的形式-质料图式和“发生构造”的一元论图式。笔者将指出，随着后期胡塞尔现象学的推进，构造的含义将更加复杂，它同时指示了自我在世界视域之中的横向结构，以及绝对时间意识支持着世界经验、并与其相互交织的纵向结构。笔者也将在此基础上，提出第三种构造图式。     

Control or Autonomy? A Case Study of two Organizational Forms in the Zhangjiakou Internal Migrant Organization

Control often weakens autonomy in organizational theories. While many scholars focus on the paradox of control and autonomy, few pay attention to how an organization obtains both control and autonomy. By exploring Zhangjiakou Internal Immigrant Organization, this study finds two mechanisms can contribute to the balanced combination of control and autonomy. First, managers play ambidextrous official-merchant roles, which means superiors take both bureaucratic and autonomous management styles. Second, members have dual organizational goals for both political status and network support. In conclusion, the successful combination is shaped by the subjective interaction between the government, superior managers and subordinate members.     

无人机军事化利用的国际法规制

无人机从20世纪初初具雏形到今天运用于许多领域,其军事化发展进程总体上看从未停止。国际法上虽然承认军事化无人机存在的合法性,但当它被用于诉诸战争权的行使时却依然存在争议,并且自主无人机需要国际人道法考量。军事化无人机必须在国际法框架下行使。在用于诉诸战争权时,应该谨慎解释"国家同意""国家同意的限制""必要性""相称性"等概念,并且严格区分普通无人机与自主无人机对国际人道主义法的挑战,让军事化无人机可以更加规范地被利用。