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Cancho Vicente G. Macera Márcia A. C. Suzuki Adriano K. Louzada Francisco Zavaleta Katherine E. C. 《Lifetime data analysis》2020,26(2):221-244
Lifetime Data Analysis - Frailty models are generally used to model heterogeneity between the individuals. The distribution of the frailty variable is often assumed to be continuous. However, there... 相似文献
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Stephen J. Ruberg Frank E. Harrell Jr. Margaret Gamalo-Siebers Lisa LaVange J. Jack Lee Karen Price 《The American statistician》2019,73(1):319-327
ABSTRACTThe cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making. 相似文献
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Sant’Anna Annibal Parracho de Freitas Siqueira Sadok Menna Barreto Márcia 《Social indicators research》2020,148(3):733-746
Social Indicators Research - This paper analyses the Human Development Index (HDI) time series from 2010 to 2017. An alternative index is studied, which combines the same components of the HDI by... 相似文献
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Although there has recently been a rise in parenting support programmes within the UK, only a minority of these programmes have benefited from evaluation of either outcomes or processes. This paper describes the development of the PALS programme (Parents Altogether Lending Support), reporting both on its effectiveness in improving parents' interactions with their children and on the lessons that were learned about embedding such a programme within the local community. Over the 18‐month period of the programme, a total of 17 courses were run, with 75 parents and carers (primarily mothers) participating in the programme overall. Evaluation results indicated that participants enjoyed the course and found it beneficial, particularly in terms of altering their own actions in specific ways that were able to promote better behaviour on the part of their children. Participants also valued the opportunity to share their experiences with other parents. The key lesson identified in regard to the development of parenting programmes concerned the need for the community to feel a sense of ownership for the initiative. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
8.
Ruffin M. Holt 《Voluntas: International Journal of Voluntary and Nonprofit Organizations》2002,13(1):94-95
VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - 相似文献
9.
Existence and Nash implementation of efficient sharing rules for a commonly owned technology 总被引:2,自引:0,他引:2
Suppose that a group of individuals owns collectively a technology which produces a consumption good by means of a (possibly
heterogeneous) input. A sharing rule associates input contributions with a vector of consumptions that are technologically
feasible. We show that the set of allocations obtained by any continuous sharing rule contains Pareto efficient allocations.
We also present a mechanism that implements in Nash equilibrium the Pareto efficient allocations contained in an arbitrary
sharing rule.
Received: 29 June 1998/Accepted: 15 November 2000 相似文献
10.
Steven M. Harris 《Journal of marital and family therapy》2002,28(3):383-387
Bailey, C. E. (Ed.) (2000). Children in therapy: Using the family as a resource. Doherty, W. J. (2001). Take back your marriage: Sticking together in a world that pulls us apart. New York: Guilford. Larson, J. H. (2000). Should we stay together? A scientically proven method for evaluating your relationship and improving its chances for long‐term success. Weiner‐Davis, M. (2001). The divorce remedy: The proven 7‐step program for saving your marriage. 相似文献