Androgen status in non-diabetic elderly men with heart failure

Purpose: We aimed at evaluating androgen status (serum testosterone [TT] and estimated free testosterone [eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival.

Methods: Seventy three non-diabetic men with HF and 20 healthy men aged over 55?years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed. TT, sex hormone binding globulin, NT-proBNP, and adipokines (adiponectin and leptin) were measured. All-cause mortality was evaluated at six years of follow-up.

Results: Androgen status (TT, eFT) was similar in elderly men with HF compared to healthy controls (4.79?±?1.65 vs. 4.45?±?1.68?ng/ml and 0.409?±?0.277 vs. 0.350?±?0.204?nmol/l, respectively). In HF patients, TT was positively associated with NT-proBNP (r=?0.371, p?=?0.001) and adiponectin levels (r?=?0.349, p?=?0.002), while inverse association was noted with fat mass (r?=??0.413, p?<?0.001). TT and eFT were independently determined by age, total fat mass and adiponectin levels in elderly men with HF (p?<?0.05 for all). Androgen status was not predictor for all-cause mortality at six years of follow-up.

Conclusions: In non-diabetic men with HF, androgen status is not altered and is not predictive of long-term outcome.     

Public Conceptions and Images of the European Union: The Case of Slovenia

The intention of this article is to show the way the conceptions and perceptions of (Western) Europe and the European Union (EU) are constructed and articulated by general public opinion as well as by political parties and intellectual circles in Slovenia as a candidate country for the accession into the EU. It is also discussed how the images concerning reference countries and the future position in the integration process are connected with the process of formation of national selfunderstanding and identity. Some elements of so-called Euro-realism which is the common denominator of prevailing European orientation are outlined and explained.