Accounting for plasma levels below detection limits in a one-compartment zero-order absorption pharmacokinetics model

We provide a simple method for fitting a one-compartment, zero-order absorption pharmacokinetics model in the presence of observations below the detection limit. This method may be extended to more complex pharmacokinetics models. We demonstrate, using a small simulation study, that the method provides accurate parameter estimates over a range of detection limits and we compare it to an ad hoc midpoint method. An applied example is provided from a pharmacokinetic investigation of a nicotine nasal spray.     

Testing for randomness in stream ciphers using the binary derivative

The binary derivative has been used to measure the randomness of a binary string formed by a pseudorandom number generator for use in cipher systems. In this paper we develop statistical properties of the binary derivative and show that certain types of randomness testing in binary derivatives are equivalent to well-established tests for randomness in the original string. A uniform method of testing randomness in binary strings is described based on using the binary derivative. We show that the new tests are faster and more powerful than several of the well-established tests for randomness.     

Conservation technology adoption decisions and the theory of planned behavior

This study of water saving technology adoption and technology investment behavior for Florida strawberry farmers represents an application of the Theory of Planned Behavior. It is compared with the Theory of Reasoned Action, and the Theory of Derived Demand. The focus is on perceived control in the decisions, first, to become an adopter of conservation technology, and, second, to invest more capital in the technology. The results lend credence to the Planned Behavior Theory but also support Derived Demand Theory, in that actual financial capability (actual control) is found important. To predict technology adoption we may need to account for both perceived and actual control. Unfettered government control of farmer technology decisions could be counterproductive, suggesting technology policy may need to include a mix of moral suasion and incentives with more modest controls.     

Evaluation readiness: improved evaluation planning using a data inventory framework

Factors intrinsic to many programs, such as ambiguously stated objectives, inadequately defined performance measures, and incomplete or unreliable databases, often conspire to limit the evaluability of these programs. Current evaluation planning approaches are somewhat constrained in their ability to overcome these obstacles and to achieve full preparedness for evaluation. In this paper, the concept of evaluation readiness is introduced as a complement to other evaluation planning approaches, most notably that of evaluability assessment. The basic products of evaluation readiness--the formal program definition and the data inventory framework--are described, along with a guide for assuring more timely and appropriate evaluation response capability to support the decision making needs of program managers. The utility of evaluation readiness for program planning, as well as for effective management, is also discussed.     

A FAMILY-OF-ORIGIN SCALE*

While family-of-origin interventions are widely used, the theoretical assumptions upon which these techniques are based are largely without empirical validation. This paper reports on the development of a family-of-origin scale that may be used in such research as well as employed as an adjunct to therapy. The resultant scale attempts to measure self-perceived levels of health in one's family of origin. Presented are data pertaining to the scale's validity, reliability, and normative sample.     

Viewpoint: A culture of despair: reflections on ‘post-modern’ architecture

The Modern Movement in architecture is dead: on this there is consensus from Right to Left. Anti-modernism, a cultural offshoot of anti-socialism, has become decidedly modish. There are, for us, two main strands to this ‘Post-Modern’ thinking – the populist and the patrician. Each, we argue, is a formalism, an elitist practice; above all, each is an avowed refusal of the emancipatory potential of modernism. Our critique of this resignation, this cultural despair, turns on an affirmation of early modernist practice; it turns on the proposition that the social content of design practice is the issue underpinning matters of aesthetic form.