Reports of Conferences, Institutes, and Seminars

Late winter and early spring of 2009 was a busy conference time for librarians. Some of the conferences held during that time are reported herein: the American Library Association Midwinter Conference, January 23–28; Electronic Resources and Libraries (E&RL), February 9–12; the North Carolina Serials Conference, March 27; the New England Technical Services Librarians' (NETSL) Spring Conference, April 17; and the Technical, Electronic and Digital Services Interest Group (TEDSIG) Spring Meeting, April 24.     

The Rheumatoid Arthritis Drug Development Model: a case study in Bayesian clinical trial simulation

The development of a new drug is a major undertaking and it is important to consider carefully the key decisions in the development process. Decisions are made in the presence of uncertainty and outcomes such as the probability of successful drug registration depend on the clinical development programmme. The Rheumatoid Arthritis Drug Development Model was developed to support key decisions for drugs in development for the treatment of rheumatoid arthritis. It is configured to simulate Phase 2b and 3 trials based on the efficacy of new drugs at the end of Phase 2a, evidence about the efficacy of existing treatments, and expert opinion regarding key safety criteria. The model evaluates the performance of different development programmes with respect to the duration of disease of the target population, Phase 2b and 3 sample sizes, the dose(s) of the experimental treatment, the choice of comparator, the duration of the Phase 2b clinical trial, the primary efficacy outcome and decision criteria for successfully passing Phases 2b and 3. It uses Bayesian clinical trial simulation to calculate the probability of successful drug registration based on the uncertainty about parameters of interest, thereby providing a more realistic assessment of the likely outcomes of individual trials and sequences of trials for the purpose of decision making. In this case study, the results show that, depending on the trial design, the new treatment has assurances of successful drug registration in the range 0.044–0.142 for an ACR20 outcome and 0.057–0.213 for an ACR50 outcome. Copyright © 2009 John Wiley & Sons, Ltd.     

Proportional hazards models: a latent competing risk approach

We propose a novel semiparametric version of the widely used proportional hazards survival model. Features include an arbitrarily rich class of continuous base-line hazards, an attractive epidemiological interpretation of the hazard as a latent competing risk model and trivial handling of censoring. Models are fitted by using a data augmentation scheme. The methodology is applied to a data set recording times to first hospitalization following clinical diagnosis of acquired immune deficiency syndrome for a sample of 169 patients.     

A NEW FAMILY OF NON-NEGATIVE DISTRIBUTIONS

We introduce a new, flexible family of distributions for non‐negative data, defined by means of a quantile function. We describe some properties of this family, and discuss several methods for estimating the parameters. The distribution is applied to an example from environmental engineering.     

On the efficiencies of some common quick estimators

The quick estimators of location and scale have broad applications and are widely used. For a variety of symmetric populations we obtain the quantiles and the weights for which the asymptotic variances of the quick estimators are minimum. These optimal quick estimators are then used to obtain the asymptotic relative efficiencies of the commonly used estimators such as trimean. gastwirth. median, midrange. and interquartile range with respect to the optimal quick estimators in order to determine a choice among them and to check whether they are unacceptably poor. In the process it is seen that the interquartile range is the optimal quick estimator of scale for Cauchy populations; but the interdecile range is in general preferable. Also the optimal estimator of the location for the logistic distribution puts weights 0.3 on each of the two quartiles and 0.4 on the median. It is shown that for the symmetric distributions, such as the beta and Tukey- lambda with [d] > 0, which have finite support and short tails, i.e. the tail exponents (Parzen, 1979) satisfy [d] < 1, the midrange and the range are the optimal quick estimators of location and scale respectively if [d] < 1/2. The class of such distributions Include the distributions with high discontinuous tails, e.g. Tukey-lambda with [d] > 1, as well as some distributions with p.d.f.'s going to zero at the ends of the finite support, such as Tukey-lambda with 1/2 < [d] < 1. As a byproduct an interesting tail correspondence between beta and Tukey-lambda distributions is seen.     

Spatio-Temporal Modeling of Residential Sales Data

This article focuses on the location, time, and spatio-temporal components associated with suitably aggregated data to improve prediction of individual asset values. Such effects are introduced in the context of hierarchical models, which we find more natural than attempting to model covariance structure. Indeed, our cross-sectional database, a sample of 7,936 transactions for 49 subdivisions over a 10-year period in Baton Rouge, Louisiana, precludes covariance modeling. A wide range of models arises, each fitted using sampling-based methods because likelihood-based fitting may not be possible. Choosing among an array of nonnested models is carried out using a posterior predictive criterion. In addition, one year of data is held out for model validation. A thorough analysis of the data incorporating all of the aforementioned issues is presented.     

Multiplicity: discussion points from the Statisticians in the Pharmaceutical Industry multiplicity expert group

In May 2012, the Committee of Health and Medicinal Products issued a concept paper on the need to review the points to consider document on multiplicity issues in clinical trials. In preparation for the release of the updated guidance document, Statisticians in the Pharmaceutical Industry held a one‐day expert group meeting in January 2013. Topics debated included multiplicity and the drug development process, the usefulness and limitations of newly developed strategies to deal with multiplicity, multiplicity issues arising from interim decisions and multiregional development, and the need for simultaneous confidence intervals (CIs) corresponding to multiple test procedures. A clear message from the meeting was that multiplicity adjustments need to be considered when the intention is to make a formal statement about efficacy or safety based on hypothesis tests. Statisticians have a key role when designing studies to assess what adjustment really means in the context of the research being conducted. More thought during the planning phase needs to be given to multiplicity adjustments for secondary endpoints given these are increasing in importance in differentiating products in the market place. No consensus was reached on the role of simultaneous CIs in the context of superiority trials. It was argued that unadjusted intervals should be employed as the primary purpose of the intervals is estimation, while the purpose of hypothesis testing is to formally establish an effect. The opposing view was that CIs should correspond to the test decision whenever possible. Copyright © 2013 John Wiley & Sons, Ltd.     

Ratio estimates and fieller's theorem in regression modelling

This paper presents applications of statistical linear models in which a confidence interval is required for the ratio of linear combinations of the model's parameters, Fieller's theorem is used to obtain the solution.     

New bootstrap confidence intervals for means of positively skewed distributions

ABSTRACT

In this paper, we consider the problem of constructing non parametric confidence intervals for the mean of a positively skewed distribution. We suggest calibrated, smoothed bootstrap upper and lower percentile confidence intervals. For the theoretical properties, we show that the proposed one-sided confidence intervals have coverage probability α + O(n^{? 3/2}). This is an improvement upon the traditional bootstrap confidence intervals in terms of coverage probability. A version smoothed approach is also considered for constructing a two-sided confidence interval and its theoretical properties are also studied. A simulation study is performed to illustrate the performance of our confidence interval methods. We then apply the methods to a real data set.     

Bootstrap MISE Estimators to Obtain Bandwidth for Kernel Density Estimation

Research in the area of bandwidth selection was an active topic in the 1980s and 1990s, however, recently there has been little research in the area. We re-opened this investigation and have found a new method for estimating mean integrated squared error for kernel density estimators. We provide an overview of other methods to obtain optimal bandwidths and offer a comparison of these methods via a simulation study. In certain situations, our method of estimating an optimal bandwidth yields a smaller MISE than competing methods to compute bandwidths. This procedure is illustrated by an application to two data sets.