Modifications of the Empirical Likelihood Interval Estimation with Improved Coverage Probabilities

The empirical likelihood (EL) technique has been well addressed in both the theoretical and applied literature in the context of powerful nonparametric statistical methods for testing and interval estimations. A nonparametric version of Wilks theorem (Wilks, 1938 Wilks , S. S. ( 1938 ). The large-sample distribution of the likelihood ratio for testing composite hypotheses . Annals of Mathematical Statistics 9 : 60 – 62 .[Crossref] , [Google Scholar]) can usually provide an asymptotic evaluation of the Type I error of EL ratio-type tests. In this article, we examine the performance of this asymptotic result when the EL is based on finite samples that are from various distributions. In the context of the Type I error control, we show that the classical EL procedure and the Student's t-test have asymptotically a similar structure. Thus, we conclude that modifications of t-type tests can be adopted to improve the EL ratio test. We propose the application of the Chen (1995 Chen , L. ( 1995 ). Testing the mean of skewed distributions . Journal of the American Statistical Association 90 : 767 – 772 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) t-test modification to the EL ratio test. We display that the Chen approach leads to a location change of observed data whereas the classical Bartlett method is known to be a scale correction of the data distribution. Finally, we modify the EL ratio test via both the Chen and Bartlett corrections. We support our argument with theoretical proofs as well as a Monte Carlo study. A real data example studies the proposed approach in practice.     

The Appropriateness of Some Common Procedures for Testing the Equality of Two Independent Binomial Populations

For testing the equality of two independent binomial populations the Fisher exact test and the chi-squared test with Yates's continuity correction are often suggested for small and intermediate size samples. The use of these tests is inappropriate in that they are extremely conservative. In this article we demonstrate that, even for small samples, the uncorrected chi-squared test (i.e., the Pearson chi-squared test) and the two-independent-sample t test are robust in that their actual significance levels are usually close to or smaller than the nominal levels. We encourage the use of these latter two tests.     

Revisiting Nested Group Testing Procedures: New Results,Comparisons, and Robustness

Group testing has its origin in the identification of syphilis in the U.S. army during World War II. Much of the theoretical framework of group testing was developed starting in the late 1950s, with continued work into the 1990s. Recently, with the advent of new laboratory and genetic technologies, there has been an increasing interest in group testing designs for cost saving purposes. In this article, we compare different nested designs, including Dorfman, Sterrett and an optimal nested procedure obtained through dynamic programming. To elucidate these comparisons, we develop closed-form expressions for the optimal Sterrett procedure and provide a concise review of the prior literature for other commonly used procedures. We consider designs where the prevalence of disease is known as well as investigate the robustness of these procedures, when it is incorrectly assumed. This article provides a technical presentation that will be of interest to researchers as well as from a pedagogical perspective. Supplementary material for this article is available online.     

Quantal Risk Assessment Database: A Database for Exploring Patterns in Quantal Dose‐Response Data in Risk Assessment and its Application to Develop Priors for Bayesian Dose‐Response Analysis

Quantitative risk assessments for physical, chemical, biological, occupational, or environmental agents rely on scientific studies to support their conclusions. These studies often include relatively few observations, and, as a result, models used to characterize the risk may include large amounts of uncertainty. The motivation, development, and assessment of new methods for risk assessment is facilitated by the availability of a set of experimental studies that span a range of dose‐response patterns that are observed in practice. We describe construction of such a historical database focusing on quantal data in chemical risk assessment, and we employ this database to develop priors in Bayesian analyses. The database is assembled from a variety of existing toxicological data sources and contains 733 separate quantal dose‐response data sets. As an illustration of the database's use, prior distributions for individual model parameters in Bayesian dose‐response analysis are constructed. Results indicate that including prior information based on curated historical data in quantitative risk assessments may help stabilize eventual point estimates, producing dose‐response functions that are more stable and precisely estimated. These in turn produce potency estimates that share the same benefit. We are confident that quantitative risk analysts will find many other applications and issues to explore using this database.     

Two‐sample empirical likelihood ratio tests for medians in application to biomarker evaluations

The median is a commonly used parameter to characterize biomarker data. In particular, with two vastly different underlying distributions, comparing medians provides different information than comparing means; however, very few tests for medians are available. We propose a series of two‐sample median‐specific tests using empirical likelihood methodology and investigate their properties. We present the technical details of incorporating the relevant constraints into the empirical likelihood function for in‐depth median testing. An extensive Monte Carlo study shows that the proposed tests have excellent operating characteristics even under unfavourable occasions such as non‐exchangeability under the null hypothesis. We apply the proposed methods to analyze biomarker data from Western blot analysis to compare normal cells with bronchial epithelial cells from a case–control study. The Canadian Journal of Statistics 39: 671–689; 2011. © 2011 Statistical Society of Canada     

A two-sample empirical likelihood ratio test based on samples entropy

Powerful entropy-based tests for normality, uniformity and exponentiality have been well addressed in the statistical literature. The density-based empirical likelihood approach improves the performance of these tests for goodness-of-fit, forming them into approximate likelihood ratios. This method is extended to develop two-sample empirical likelihood approximations to optimal parametric likelihood ratios, resulting in an efficient test based on samples entropy. The proposed and examined distribution-free two-sample test is shown to be very competitive with well-known nonparametric tests. For example, the new test has high and stable power detecting a nonconstant shift in the two-sample problem, when Wilcoxon’s test may break down completely. This is partly due to the inherent structure developed within Neyman-Pearson type lemmas. The outputs of an extensive Monte Carlo analysis and real data example support our theoretical results. The Monte Carlo simulation study indicates that the proposed test compares favorably with the standard procedures, for a wide range of null and alternative distributions.