A joint model of cancer incidence,metastasis, and mortality

Many diseases, especially cancer, are not static, but rather can be summarized by a series of events or stages (e.g. diagnosis, remission, recurrence, metastasis, death). Most available methods to analyze multi-stage data ignore intermediate events and focus on the terminal event or consider (time to) multiple events as independent. Competing-risk or semi-competing-risk models are often deficient in describing the complex relationship between disease progression events which are driven by a shared progression stochastic process. A multi-stage model can only examine two stages at a time and thus fails to capture the effect of one stage on the time spent between other stages. Moreover, most models do not account for latent stages. We propose a semi-parametric joint model of diagnosis, latent metastasis, and cancer death and use nonparametric maximum likelihood to estimate covariate effects on the risks of intermediate events and death and the dependence between them. We illustrate the model with Monte Carlo simulations and analysis of real data on prostate cancer from the SEER database.     

Getting back in the DeLorean: modernization vs. anti-modernization in contemporary British politics

ABSTRACT

This article highlights a growing clash between mainstream modernizing and populist anti-modernizing forces in the UK. Whilst scholarship on UK party politics has, for the past three decades, focussed on processes of party modernization, little attention has been paid to the countervailing processes of resistance towards modernization. This contrasts with comparative studies, which show that throughout much of Europe modernization processes have worked to produce populist backlashes from anti-modernizing forces seeking to reassert various types of traditional values and practices. Drawing on the comparative literature on modernization, our argument here is that a similar populist backlash against modernization is occurring across the political spectrum in the UK and has been a factor in: the rise of nationalism associated with UKIP and the SNP; the 2016 BREXIT vote and the efforts of both Labour leader Jeremy Corbyn and Conservative PM Theresa May to distance their parties from the legacies of their modernizing predecessors. Empirically, we show how this increasingly prevalent line of conflict is playing out in the UK, whilst theoretically we argue that a discourse theoretical approach can provide significant advantages over existing approaches for understanding the dynamic interplay between modernizing and anti-modernizing discourses.     

Austérité budgétaire et flexibilisation du marché du travail: une association risquée

Les auteurs évaluent les effets de l'association entre politiques d'austérité budgétaire et de réduction du coût du travail, et apportent ainsi quelque éclairage sur les débats en cours. Ils s'attaquent au problème de l'agrégation dans une perspective mondiale au moyen d'un macromodèle mettant en évidence la dynamique de la répartition. La flexibilisation réduit la part salariale et entraîne des rétroactions qui s'enchaînent dans une spirale descendante avec une contraction de l'activité, même dans les économies tirées par les exportations. Les gains initiaux de compétitivité se révèlent éphémères. Sur le long terme, les salaires sont les premiers moteurs de l'économie mondiale, qui réagit positivement aux stimuli keynésiens coordonnés.     

Cognitive Modifiability of New Immigrant Adults

The first research question of this study concerns the plasticity of cognitive processes of adult learners confronted with the task of adapting to a new language and an unfamiliar system of formal education. The second question inquires into the relative contribution of two different forms of cognitive intervention—the Learning Potential Assessment Device (LPAD) procedure and the cognitive education program—to the cognitive modifiability of immigrant adults. Both forms of intervention were studied in the past but never in comparison. It seemed, therefore, important to compare the performance of immigrant adult students who received only the LPAD procedure with that of the students who received both LPAD and a prolonged cognitive intervention. The results indicate that the cognitive processes of adult immigrants are modifiable, often no less than those of school-age children and that the participation in cognitive education program has an added value for students with relatively high preprogram performance as compared to LPAD alone.     

The Role of Active Listening in Teacher–Parent Relations and the Moderating Role of Attachment Style

This study tested the perceived effectiveness of “Listening-Ask questions-Focus on the issue–Find a first step” method (McNaughton et al., 2008) in a parent–teacher conversation using a scenario study (N?=?208). As expected, a scenario based on this method compared with a scenario of a conversation omitting the four steps of the method was perceived both by teachers and parents as more effective (d?=?1.43). Moreover, it was hypothesized that the effectiveness of this listening method would be found largely among secure participants. Indeed, the findings suggested that anxious people were less sensitive to the manipulation. Research hypotheses regarding avoidant attachment style were not supported, suggesting that more research is needed to better understand the moderating role of attachment style.     

Pre-commitment in gambling: a review of the empirical evidence

Norway, a Canadian province and Australia have introduced, or are considering introducing, voluntary or mandatory pre-commitment systems for electronic gaming machines. This paper critically reviews the empirical literature evaluating the effectiveness of such systems as a responsible gambling strategy. A literature search identified 17 relevant peer- and non-peer-reviewed publications. Self-report data suggests the majority of gamblers are positively predisposed to the concept of pre-commitment but non-problem and low-risk gamblers regard the system as personally unnecessary. Overall, studies reported variable findings relating to adherence to money limits and expenditure. Few gamblers appear to use options to set time limits. Methodological flaws such as low participation rates, compromised data integrity resulting from card sharing and failure to control for concurrent gambling outside trials limit conclusions drawn regarding the effectiveness of pre-commitment. It is recommended that further systematic trials should be implemented to determine the impact of pre-commitment systems on gamblers' behaviour.     

“Sometimes,I think I might say too much”: Dark Secrets and the Performance of Inflammatory Bowel Disease*

This study examines the dramaturgical embodiment of chronically ill bodies managing “fecal matters” (Weinberg and Williams 2005) in Inflammatory Bowel Disease (IBD) support groups. Data were derived from my reflections as a person with IBD, a year of participant observation, and semi‐structured interviews with support group members. I first uncover the boundaries of the private body (Cahill 2006). Secondly, I focus on the entrenchment of IBD within the stigma of fecal matters. Lastly, I explore the disparate ways that support group members harnessed language to protect their embodied selves from symbolic fecal contamination, from a “soiled self.”     

Institutional processes of organizational culture

Queries into the creation of collective meaning through social processes arise in both organization culture and institutional theory. This paper applies DiMaggio and Powell’s (1983 DiMaggio, P.J. and Powell, W.W. 1983. The iron cage revisited: Institutional isomorphism and collective rationality in organizational fields. American Sociological Review, 48: 147–60. [Crossref], [Web of Science ®] , [Google Scholar]) three isomorphic processes (mimetic, normative and coercive) from institutional theory to re‐think how structural and dynamic aspects of culture become nested, taken‐for‐granted and transmitted. We consider both acquiescence and resistance to isomorphic pressures in an effort to understand cultural persistence and transmission, forms of resistance to culture, change, the role of sub‐cultures and power usage through Oliver’s (1992 Oliver, C. 1992. The antecedents of de‐institutionalization. Organization Studies, 13: 563–88. [Crossref], [Web of Science ®] , [Google Scholar]) de‐institutionalization thesis. Our purpose in applying isomorphic processes to organizational culture is to offer another layer of understanding enhanced by the growing body of research in institutional theory, bridge one division between micro and macro theory and provide some suggestions for future research.     

Inter- and transdisciplinary approaches to population–environment research for sustainability aims: a review and appraisal

The causes and consequences of demographic changes for the environment, and the possible ways of influencing population dynamics to achieve ‘sustainability’, have been the subject of many debates in science and policy in recent decades. However, the body of knowledge concerning relationships between population dynamics and sustainability is quite fragmented, dispersed over many disciplines, and encompasses diverse theories, paradigms and methodologies. This paper reviews four selected frameworks: linear, multiplicative, mediated, and system-theoretical approaches and perspectives. We represent how population–environment relationships are conceptualized, provide examples of research questions and accepted approaches, and critically assess their utility for different sorts of research for sustainable development. We note the growing recognition of the value of embracing complexity in population–environment research, and how this is consistent with normative aims of development.