Analysis of clustered spatially correlated binary data using autologistic model and Bayesian method with an application to dental caries of 3–5-year-old children

The autologistic model, first introduced by Besag, is a popular tool for analyzing binary data in spatial lattices. However, no investigation was found to consider modeling of binary data clustered in uncorrelated lattices. Owing to spatial dependency of responses, the exact likelihood estimation of parameters is not possible. For circumventing this difficulty, many studies have been designed to approximate the likelihood and the related partition function of the model. So, the traditional and Bayesian estimation methods based on the likelihood function are often time-consuming and require heavy computations and recursive techniques. Some investigators have introduced and implemented data augmentation and latent variable model to reduce computational complications in parameter estimation. In this work, the spatially correlated binary data distributed in uncorrelated lattices were modeled using autologistic regression, a Bayesian inference was developed with contribution of data augmentation and the proposed models were applied to caries experiences of deciduous dents.     

Testing the equality of quantiles for several normal populations

Many procedures exist for testing equality of means or medians to compare several independent distributions. However, the mean or median do not determine the entire distribution. In this article, we propose a new small-sample modification of the likelihood ratio test for testing the equality of the quantiles of several normal distributions. The merits of the proposed test are numerically compared with the existing tests—a generalized p-value method and likelihood ratio test—with respect to their sizes and powers. The simulation results demonstrate that proposed method is satisfactory; its actual size is very close to the nominal level. We illustrate these approaches using two real examples.     

Risk Management in a Polio-Free World

Inherent in the decision to launch the Global Polio Eradication Initiative in 1988 was the expectation for many people that immunization against poliomyelitis would eventually simply stop, as had been the case with smallpox following its eradication in 1977. However, the strategies for managing the risks associated with a "polio-free" world must be continuously refined to reflect new developments, particularly in our understanding of the live polioviruses in the oral poliovirus vaccine (OPV) and in the international approach to managing potential biohazards. The most important of these developments has been the confirmation in 2000 that vaccine-derived polioviruses (VDPVs) can circulate and cause polio outbreaks, making the use of OPV after interruption of wild poliovirus transmission incompatible with a polio-free world. A comprehensive strategy has been developed to minimize the risks associated with eventual OPV cessation, centered on appropriate long-term biocontainment of poliovirus stocks (whether for vaccine production, diagnosis, or research), the controlled reintroduction of any live poliovirus vaccine (i.e., from an OPV stockpile), and appropriate use of the inactivated poliovirus vaccine (IPV). Although some aspects of this risk management strategy are still debated, there is wide agreement that no strategy would entirely eliminate the potential risks to a polio-free world. The current strategy for risk management in a polio-free world will continue to evolve with better characterization of these risks and the development of more effective approaches both to reduce those risks and to limit their consequences should they occur.     

Skew-mixed effects model for multivariate longitudinal data with categorical outcomes and missingness

A longitudinal study commonly follows a set of variables, measured for each individual repeatedly over time, and usually suffers from incomplete data problem. A common approach for dealing with longitudinal categorical responses is to use the Generalized Linear Mixed Model (GLMM). This model induces the potential relation between response variables over time via a vector of random effects, assumed to be shared parameters in the non-ignorable missing mechanism. Most GLMMs assume that the random-effects parameters follow a normal or symmetric distribution and this leads to serious problems in real applications. In this paper, we propose GLMMs for the analysis of incomplete multivariate longitudinal categorical responses with a non-ignorable missing mechanism based on a shared parameter framework with the less restrictive assumption of skew-normality for the random effects. These models may contain incomplete data with monotone and non-monotone missing patterns. The performance of the model is evaluated using simulation studies and a well-known longitudinal data set extracted from a fluvoxamine trial is analyzed to determine the profile of fluvoxamine in ambulatory clinical psychiatric practice.     

Bayesian spatial prediction of skew and censored data via a hybrid algorithm

A correct detection of areas with excess of pollution relies first on accurate predictions of pollutant concentrations, a task that is usually complicated by skewed histograms and the presence of censored data. The unified skew-Gaussian (SUG) random field proposed by Zareifard and Jafari Khaledi [19] offers a more flexible class of sampling spatial models to account for skewness. In this paper, we adopt a Bayesian framework to perform prediction for the SUG model in the presence of censored data. Owing to the presence of many latent variables with strongly dependent components in the model, we encounter convergence issues when using Monte Carlo Markov Chain algorithms. To overcome this obstacle, we use a computationally efficient inverse Bayes formulas sampling procedure to obtain approximately independent samples from the posterior distribution of latent variables. Then they are applied to update parameters in a Gibbs sampler scheme. This hybrid algorithm provides effective samples, resulting in some computational advantages and precise predictions. The proposed approach is illustrated with a simulation study and applied to a spatial data set which contains right censored data.     

Bayesian A- and D-optimal designs for gamma regression model with inverse link function

Bayesian optimal designs have received increasing attention in recent years, especially in biomedical and clinical trials. Bayesian design procedures can utilize the available prior information of the unknown parameters so that a better design can be achieved. With this in mind, this article considers the Bayesian A- and D-optimal designs of the two- and three-parameter Gamma regression model. In this regard, we first obtain the Fisher information matrix of the proposed model and then calculate the Bayesian A- and D-optimal designs assuming various prior distributions such as normal, half-normal, gamma, and uniform distribution for the unknown parameters. All of the numerical calculations are handled in R software. The results of this article are useful in medical and industrial researches.     

A non-homogeneous skew-Gaussian Bayesian spatial model

In spatial statistics, models are often constructed based on some common, but possible restrictive assumptions for the underlying spatial process, including Gaussianity as well as stationarity and isotropy. However, these assumptions are frequently violated in applied problems. In order to simultaneously handle skewness and non-homogeneity (i.e., non-stationarity and anisotropy), we develop the fixed rank kriging model through the use of skew-normal distribution for its non-spatial latent variables. Our approach to spatial modeling is easy to implement and also provides a great flexibility in adjusting to skewed and large datasets with heterogeneous correlation structures. We adopt a Bayesian framework for our analysis, and describe a simple MCMC algorithm for sampling from the posterior distribution of the model parameters and performing spatial prediction. Through a simulation study, we demonstrate that the proposed model could detect departures from normality and, for illustration, we analyze a synthetic dataset of CO\(_2\) measurements. Finally, to deal with multivariate spatial data showing some degree of skewness, a multivariate extension of the model is also provided.     

Minimax Estimation of the Bounded Parameter of Some Discrete Distributions Under LINEX Loss Function

For a class of discrete distributions, including Poisson(θ), Generalized Poisson(θ), Borel(m, θ), etc., we consider minimax estimation of the parameter θ under the assumption it lies in a bounded interval of the form [0, m] and a LINEX loss function. Explicit conditions for the minimax estimator to be Bayes with respect to a boundary supported prior are given. Also for Bernoulli(θ)-distribution, which is not in the mentioned class of discrete distributions, we give conditions for which the Bayes estimator of θ ∈ [0, m], m < 1 with respect to a boundary supported prior is minimax under LINEX loss function. Numerical values are given for the largest values of m for which the corresponding Bayes estimators of θ are minimax.     

Gompertz-power series distributions

ABSTRACT

In this article, we introduce the Gompertz power series (GPS) class of distributions which is obtained by compounding Gompertz and power series distributions. This distribution contains several lifetime models such as Gompertz-geometric (GG), Gompertz-Poisson (GP), Gompertz-binomial (GB), and Gompertz-logarithmic (GL) distributions as special cases. Sub-models of the GPS distribution are studied in details. The hazard rate function of the GPS distribution can be increasing, decreasing, and bathtub-shaped. We obtain several properties of the GPS distribution such as its probability density function, and failure rate function, Shannon entropy, mean residual life function, quantiles, and moments. The maximum likelihood estimation procedure via a EM-algorithm is presented, and simulation studies are performed for evaluation of this estimation for complete data, and the MLE of parameters for censored data. At the end, a real example is given.