Use of Biological Markers in Risk Assessment1

Measurements of intermediate end points in the carcinogenic process may reduce uncertainty in human risk assessment from bioassay data, by identifying sources of interspecies variation and dose nonlinearity. This paper describes desirable properties of such markers: persistence, predictive power, temporal relevance, and consistency across dose rate and species. We illustrate these properties by evaluating markers for squamous cell nasal carcinoma in rodents exposed to formaldehyde. We also discuss design issues for bioassays that evaluate markers and tumors simultaneously at necropsy.     

Applying Decision Analysis to Determine the Effect of Smoke Detector Laws on Fire Loss in the United States

Decision analysis is used to examine whether residential smoke detectors should be required by law. Statistics pertaining to fire incidence, fire death, smoke detector efficacy, and the consequences of fire are examined for accuracy and availability and combined in a decision model. A sensitivity analysis is performed on the model inputs. Included in the analysis is the idea that homes with detectors may have lower death rates due to the characteristics of those who purchase detectors rather than the detectors themselves. Results from the base case estimate show an expected cost of $65,000 per life saved when a law is enacted. This value lies well below the value implied by spending on other public safety programs.     

Pathways Among Marital Distress,Parental Symptomatology,and Child Adjustment

A community sample of 295 mothers, fathers, and children (M age = 11.14 years, SD = 2.32 years) rated marital distress, maternal and paternal psychological symptoms, and child adjustment. The predicted direct relations between these family and child variables were demonstrated for both fathers and mothers. Tests of pathways among these variables were conducted for separate but complementary mediation models. Maternal and paternal symptoms mediated the association between marital distress and child adjustment. Marital distress mediated the link between fathers’ symptoms and child adjustment, but the direct pathway between mothers’ symptoms and child adjustment remained. Pubertal status was modestly related to higher levels of family stressors. Joint implications of marital distress and parental symptoms for child adjustment are discussed.     

Family Trajectories and Well-being of Children Born to Lone Mothers in the UK

We investigate how lone mothers’ heterogeneity in partnership trajectories is associated with children’s well-being. We use data from the Millennium Cohort Study, which follows a large sample of children born in the UK in 2000–2002. We divide children who were born to lone mothers into four groups based on their mothers’ partnership trajectories between birth and age seven, which cover more than 80% of these children’s family experiences. We then analyse how these trajectories are associated with markers of health, cognitive and socio-emotional outcomes measured at around age seven. We find that compared to the children that live continuously with lone mothers, children whose biological father stably joined the household have better cognitive and socio-emotional outcomes. In contrast, children in trajectories characterised by living with a stepfather or who experienced biological father joining in the family followed by biological parents’ dissolution had outcomes similar to children living continuously with lone mothers. The results underscore the importance of treating children born to lone mothers as a heterogeneous category.     

Principal points of univariate continuous distributions

The K principal points of a p-variate random variable X are defined as those points ₁,..., _K which minimize the expected squared distance of X from the nearest of the _k . This paper reviews some of the theory of principal points and presents a method of determining principal points of univariate continuous distributions. The method is applied to the uniform distribution, to the normal distribution and to the exponential distribution.     

Encountering and dealing with difference: second life and intercultural competence

With increasing cultural diversity as a result of globalization, intercultural competence (IC) to interact and co-exist in multicultural environments is recognized as being very important. Research indicates that cultural knowledge alone, or even being immersed in a different cultural environment does not necessarily lead to the development of IC necessary to deal with differences in behaviour, communication styles, and values and beliefs. Rather, it requires intentional development particularly of critical awareness of an individual’s cultural identity, and the values and beliefs that underpin one’s attitude and behaviour. Providing effective learning and teaching approaches to facilitate development of these affective and behavioural dimensions, challenges traditional pedagogical practices. Second life (SL), a multi-user virtual environment, potentially provides effective intercultural experiential learning opportunities to develop the desired IC by challenging personal beliefs and assumptions underpinning cultural frameworks and identity. This paper evaluates SL as one of the approaches used to develop IC in a first year IC module in a New Zealand university. Based on data from two case studies, it presents and discusses significant findings in terms of using SL and the development of students’ IC.     

Embodiment,care and practice in a community kitchen

This article explores activist practices in a community kitchen based in the south of the United Kingdom with a dual focus on social and environmental justice. It draws on these practices to develop further feminist, and specifically ecofeminist, concepts of care ethics by arguing that embodiment is an essential element in lived relationships of care. Moreover, we show that these embodied components enable learning that can disrupt settled understandings of social and environmental injustices, including negotiating tensions relating to class and race. We demonstrate how this disruption combines with imaginative processes to stimulate critical political analysis of the relationship between local contexts of need and broader socio‐political structures and power relations. Crucially, we work towards illuminating how care ethics and social practice combine to stimulate and inform political action.     

DPR Debate: Growth Identification and Facilitation: The Role of the State in the Dynamics of Structural Change

This DPR Debate is based on the contribution by Justin Lin, Chief Economist at the World Bank, and his colleague Célestin Monga, on ‘Growth Identification and Facilitation: The Role of the State in the Dynamics of Structural Change’. The article under consideration is important and timely as it articulates a number of new policy implications from Justin Lin's earlier work on New Structural Economics, which was discussed in a previous DPR debate (Lin and Chang, 2009). This symposium contains the article and comments on it from five distinguished specialists, and closes with a rejoinder by Lin and Monga. This introduction discusses the article, the comments and the rejoinder. The historical record indicates that, in all successful economies, the state has always played an important role in facilitating structural change and helping the private sector sustain it across time. This article puts forward a new approach to help policy‐makers in developing countries identify those industries that may hold latent comparative advantage, and recommends ways of removing binding constraints to facilitate private firms' entry into those industries. Two types of government interventions are distinguished: first, policies that facilitate structural change by overcoming information, co‐ordination and externality issues, which are intrinsic to industrial upgrading and diversification; and second, policies aimed at protecting certain selected firms and industries that defy the comparative advantage determined by the existing endowment structure.