细胞重组:机遇与挑战

人诱导性多能干(iPS)细胞能够分化成很多种类的祖细胞,这为临床和研究提供了新的机遇。这些细胞系可以用于疾病模型的建立、药物筛选以及毒性测试、帮助解决传统方法的局限性,也可以建立人类各种复杂疾病的细胞模型,对应用于更加个性化的医药研究领域也很有潜力。这些细胞系具有重新塑造临床研究领域的潜力,但是研究人员也面临着很多问题和挑战,也需要去发现新的应用。     

Reducing Firearm-Related Violence on College Campuses—Police Chiefs' Perceptions and Practices

Abstract

Context: Firearms are used in the majority of college aged suicides and homicides. With recent efforts by various gun lobbying groups to have firearms more accessible to college students on campuses, there is the potential for more firearm-related morbidity and mortality. Objective: This study assessed university police chiefs’ perceptions and practices concerning selected issues of firearm violence and its reduction on college campuses. Participants: The Directory of the International Association for College Law Enforcement Administrators was used to identify a national random sample of campus police chiefs (n = 600). The respondents were predominantly males (89%), 40 to 59 years of age (71%), Caucasian (85%), and worked for 21or more years in law enforcement (75%). Methods: In the fall of 2008, a 2-wave mailing procedure was used to ensure an adequate response rate to a valid and reliable questionnaire. Results: A total of 417 (70%) questionnaires were returned. A firearm incident had occurred in the past year on 25% of campuses and on 35% of campuses within the past 5 years. The majority of campuses (57%) had a plan in place for longer than a year to deal with an “active shooter” on campus. Virtually all (97%) of the campuses had a policy in place that prohibited firearms on campus. The primary barrier (46%) to a highly visible campus plan for preventing firearms violence was the perception that firearms violence was not a problem on their campus. Conclusions: A greater awareness of the importance of a highly visible campus firearm policy and its potential for reducing firearm trauma on college campuses is needed.     

Estimating the National Public Health Burden Associated with Exposure to Ambient PM2.5 and Ozone

Ground‐level ozone (O₃) and fine particulate matter (PM_2.5) are associated with increased risk of mortality. We quantify the burden of modeled 2005 concentrations of O₃ and PM_2.5 on health in the United States. We use the photochemical Community Multiscale Air Quality (CMAQ) model in conjunction with ambient monitored data to create fused surfaces of summer season average 8‐hour ozone and annual mean PM_2.5 levels at a 12 km grid resolution across the continental United States. Employing spatially resolved demographic and concentration data, we assess the spatial and age distribution of air‐pollution‐related mortality and morbidity. For both PM_2.5 and O₃ we also estimate: the percentage of total deaths due to each pollutant; the reduction in life years and life expectancy; and the deaths avoided according to hypothetical air quality improvements. Using PM_2.5 and O₃ mortality risk coefficients drawn from the long‐term American Cancer Society (ACS) cohort study and National Mortality and Morbidity Air Pollution Study (NMMAPS), respectively, we estimate 130,000 PM_2.5‐related deaths and 4,700 ozone‐related deaths to result from 2005 air quality levels. Among populations aged 65–99, we estimate nearly 1.1 million life years lost from PM_2.5 exposure and approximately 36,000 life years lost from ozone exposure. Among the 10 most populous counties, the percentage of deaths attributable to PM_2.5 and ozone ranges from 3.5% in San Jose to 10% in Los Angeles. These results show that despite significant improvements in air quality in recent decades, recent levels of PM_2.5 and ozone still pose a nontrivial risk to public health.     

Research Training and Professional Social Work Education: Developing Research‐Minded Practice

The movement towards developing practice more firmly grounded on empirical research has, arguably, been one of the most significant international trends in social work during the past decade. However, in the UK the implications of this trend for pedagogical practices and the design of educational programmes have still to be fully explored. This paper reports on the findings of a repeated cross‐sectional survey of MSW students in Queen's University Belfast which focused on their perceptions of the value of research training to professional practice. The study, conducted over a four year period, explored students' awareness of the relationship between research and practice and their readiness to engage with research training. The findings suggested that the majority of students perceived research training as a valuable component of professional development. However, the study also found a level of scepticism among students about its practical utility along with some resistance towards actively embracing a research agenda. The paper evaluates the significance of these findings for developing research and evidence‐based practice as integral components of the new degrees in social work in the UK and for social work education programmes in other countries aiming to develop research‐minded practice.     

The Economimesis of New Historicism (Or How New Historicism Displaced Theory in English Literature Departments)

The form of historicism that has had most impact in the context of literary theory in the Anglophone academy is new historicism. The label new historicism was applied to an initially American mode of literary study that emerged in the late 1970s in the context of “heated discussions” surrounding theorised forms of literary study like Marxism, feminism, psychoanalysis, structuralism, post‐structuralism and deconstruction. Having emerged in this context, however, new historicism — and the more broader forms of historicist study that have migrated across a variety of disciplines in the arts and humanities — has thrived in the Academy while interest in “theory” has declined since the 1990s. In this article I propose to look closely at the reasons for the survival and success of new historicism, even as other, more radical modes of analysis have become unfashionable.     

Moral Residue: Difficult Ethical Choices in the Treatment of Refractory Anorexia Nervosa

The case of a 30-year-old woman with treatment refractory anorexia is presented through a first person narrative and countertransference experience. The case study attempts to explore how ethical treatment decisions are made, while also addressing how we live with those choices.