Application of an imputation method for variance estimation under pseudo-likelihood when missing data are NMAR

When data are outcome-dependent non response, pseudo-likelihood yields consistent regression coefficients without specifying the missing data mechanism. However, it is onerous to derive parameter estimators including their standard errors from the regression coefficients under pseudo-likelihood (PL). The present study applies an imputation method to compute the asymptotic standard errors of parameter estimators. The proposed method is simpler than Delta method and it showed similar effect size of the standard errors to bootstrapping in simulation and application studies.     

Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation

Children represent a large underserved population of “therapeutic orphans,” as an estimated 80% of children are treated off‐label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove these barriers, increased recent attention has been paid to extrapolation; that is, the leveraging of available data from adults or older age groups to draw conclusions for the pediatric population. The Bayesian statistical paradigm is natural in this setting, as it permits the combining (or “borrowing”) of information across disparate sources, such as the adult and pediatric data. In this paper, authored by the pediatric subteam of the Drug Information Association Bayesian Scientific Working Group and Adaptive Design Working Group, we develop, illustrate, and provide suggestions on Bayesian statistical methods that could be used to design improved pediatric development programs that use all available information in the most efficient manner. A variety of relevant Bayesian approaches are described, several of which are illustrated through 2 case studies: extrapolating adult efficacy data to expand the labeling for Remicade to include pediatric ulcerative colitis and extrapolating adult exposure‐response information for antiepileptic drugs to pediatrics.     

Community Informant Explanations for Unusual Neighborhood Rates of Child Maltreatment Reports

This study explored perceptions of community informants on socioenvironmental factors that explain why rates of child maltreatment reporting are different in neighborhoods with similar population characteristics. This study used data from the SoCal Neighborhoods and Child Welfare study, a multiphase, mixed-methods study of neighborhoods in Los Angeles and San Diego counties. Semistructured qualitative interviews with key informants (N = 28) in 22 census tracts explored factors that account for differences in maltreatment rates among sociodemographically similar neighborhoods. Thematic content analysis revealed three themes regarding neighborhood contributors to maltreatment behaviors and reporting: (a) community norms and values, (b) community resources and providers, and (c) housing dynamics and built environment. Findings indicate complexity in forces that affect maltreatment behavior and reporting. Adding to research on neighborhood social dynamics and child maltreatment, findings suggest that composite indicators of maltreatment within neighborhoods are affected by maltreatment behaviors and the definition, recognition, and reporting of maltreatment.     

The Impact of the Physical Home Environment for Family Carers of People with Dementia: A Qualitative Study

Background: The majority of people with dementia are cared for by their families at home. This study aimed to elicit family carers' perceptions on home environmental aspects and strategies with the view to identify barriers and facilitators when caring for a person with dementia at home.

Design and methods: Thirteen co-resident family carers were engaged in semi-structured in-depth walking interviews. Interviews were recorded, transcribed and analysed using thematic analysis.

Results: Home environments can pose a number of challenges and opportunities. Aspects of the architectural and interior environment (e.g. size, condition, layout and accessibility, familiarity) are perceived as important (Theme 1) as well as a plethora of environmental strategies that encourage independence and comfort at home (Theme 2). Carers' scepticism, timing, costs, property characteristics and mistrust to services are some barriers to implementing environmental strategies (Theme 3).

Conclusions: Carers improvised solutions via trial and error and need further education on strategies to create an enabling and comfortable home environment.     

Influence of Proximity to Kin on Residential Mobility and Destination Choice: Examining Local Movers in Metropolitan Areas

A growing body of research has examined how family dynamics shape residential mobility, highlighting the social—as opposed to economic—drivers of mobility. However, few studies have examined kin ties as both push and pull factors in mobility processes or revealed how the influence of kin ties on mobility varies across sociodemographic groups. Using data on local residential moves from the Panel Study of Income Dynamics (PSID) from 1980 to 2013, we find that location of noncoresident kin influences the likelihood of moving out of the current neighborhood and the selection of a new destination neighborhood. Analyses of out-mobility reveal that parents and young adult children living near each other as well as low-income adult children living near parents are especially deterred from moving. Discrete-choice models of neighborhood selection indicate that movers are particularly drawn to neighborhoods close to aging parents, white and higher-income households tend to move close to parents and children, and lower-income households tend to move close to extended family. Our results highlight the social and economic trade-offs that households face when making residential mobility decisions, which have important implications for broader patterns of inequality in residential attainment.     

Examining educational inequalities in two national systems: a comparison of the North African second generation in France and the Mexican second generation in the United States

This paper aims to compare the educational outcomes of children of immigrants in France and in the United States to highlight the ethnic educational inequalities in both countries. The comparison focuses on children from two groups: North Africans in France and Mexicans in the United States. By using two longitudinal datasets, the French Educational Panel Survey and Add Health, we examine aspirations, expectations, and secondary attainment in the two contexts. We explore in particular the role of parental education on attainment. Immigrant families have high educational aspirations in both contexts. North-African families express higher aspirations than native French with similar background, while there are no significant differences between second-generation Mexicans and the majority group net of parental education. Second-generation children are disadvantaged in school in both countries; they are more likely to drop out and less likely to graduate from high school, but most of the disadvantage is related to their social background. Net of social background, the Mexican second generation does not differ from the majority group while the North African second generation is more likely to get the French high school diploma than their peers of French origins, in line with their high aspirations. However, North Africans are more likely to receive the technological baccalauréat than the general baccalauréat.     

Betting Decision Under Break-Streak Pattern: Evidence from Casino Gaming

Cognitive bias is prevalent among gamblers, especially those with gambling problems. Grounded in the heuristics theories, this study contributes to the literature by examining a cognitive bias triggered by the break streak pattern in the casino setting. We postulate that gamblers tend to bet on the latest outcome when there is a break-streak pattern. Moreover, three determinants of the betting decision under break-streak pattern, including the streak length of the alternative outcome, the frequency of the latest outcome, and gender, were identified and examined in this study. A non-participatory observational study was conducted among the Cussec gamblers in a casino in Macao. An analysis of 1229 bets confirms our postulation, particularly when the streak of the alternative outcome is long, the latest outcome is frequent, and the gamblers are females. The findings provide meaningful implications for casino management and public policymakers regarding the minimization of gambling harm.