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61.

Due to weak state and administrative capacity, the Russian government has involved resource-rich non-state actors into policy-making since about 2005 and established numerous institutionalized platforms, networks, and forums. These networks mainly emerge on regional and local levels and are designed to generate policy advice, implement decisions, and contribute to output legitimacy. A crucial question is how the authorities govern and regulate these bodies under the terms of a hybrid regime. The paper sheds light on why and how state authorities interact with non-state actors and unravels functions and flavors of governance networks in Russia. Drawing on the empirical results of case studies on anti-drug policy conducted in the regions Samara and St Petersburg, the paper reveals that state dominance within networks is a significant characteristic, although authorities rarely apply explicit ‘hard’ tools of government onto collaborations with non-state actors. The paper also allows for theorizing on the role of governance networks in a hybrid regime.

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62.
This article discusses the ways in which insights from critical race theory can be used in order to supplement and reinforce the field of Disability Studies by highlighting the intersecting and contextually contingent ways in which the notion of disability is constructed and positioned. The cross-fertilization of critical race theory and Disability Studies can enhance understanding of the intersecting effects of racism and disablism through a reflexive process of exploring points of convergence and divergence of racial and corporeal markers of difference. These understandings should permeate anti-discrimination legislation and other education policy frameworks aimed at redressing systemic injustices and power inequities that impact upon disabled people’s identities and lived experiences.  相似文献   
63.
We use data from the 2006 American Community Survey to examine race and ethnic differences in the effects of marital status and co-residence of the middle generation on the likelihood of poverty among grandfathers who have primary responsibility for co-resident grandchildren (N = 3,379). Logistic regression results indicate that race/ethnicity and household composition are significant predictors of poverty for grandfather caregivers: non-Hispanic white grandfathers, those who are married, and those with a co-resident middle generation are the least likely to be poor. The effects of race/ethnicity, marital status, and the presence of a middle generation are, however, contingent upon one another. Specifically, the negative effect of being married is lower among grandfathers who are Hispanic, African American, non-Hispanic, and non-Hispanics of other race/ethnic groups compared to whites. In addition, having a middle generation in the home has a larger negative effect on poverty for race/ethnic minority grandfathers than for non-Hispanic whites. Finally, the combined effects of marriage and a middle generation vary across race/ethnic group and are associated with lower chances of poverty among some groups compared with others. We use the theory of cumulative disadvantage to interpret these findings and suggest that race/ethnicity and household composition are synergistically related to economic resources for grandfather caregivers.  相似文献   
64.
We introduce a new design for dose-finding in the context of toxicity studies for which it is assumed that toxicity increases with dose. The goal is to identify the maximum tolerated dose, which is taken to be the dose associated with a prespecified “target” toxicity rate. The decision to decrease, increase or repeat a dose for the next subject depends on how far an estimated toxicity rate at the current dose is from the target. The size of the window within which the current dose will be repeated is obtained based on the theory of Markov chains as applied to group up-and-down designs. But whereas the treatment allocation rule in Markovian group up-and-down designs is only based on information from the current cohort of subjects, the treatment allocation rule for the proposed design is based on the cumulative information at the current dose. We then consider an extension of this new design for clinical trials in which the subject's outcome is not known immediately. The new design is compared to the continual reassessment method.  相似文献   
65.
This article explores the multiple and shifting ways in which disability intersects with other sources of social disadvantage. Disablism forms part of an intricate web of social conditions that subjugate certain forms of ‘student-subjects' and create compounding forms of oppression and exclusion that need to be addressed through relevant education policy and practice. Intersectional understandings of disability expose the multiple dynamics that impact upon constructing disabled students' identities. These identities should not be regarded as fixed and transcendental entities gauged against varied bodily, mental and psychological differences, but should be understood in conjunction with the ways in which race, gender and socio-economic status intersect with the experience of disability. Intersectional understandings of disability, drawn from intersectional feminism and disability studies, destabilize reductionist accounts of individual pathology and privilege new forms of pedagogical thinking and acting that prioritize a social justice framework in tackling wider systemic rigidities and oppressive educational regimes.  相似文献   
66.
Abstract Using data from the 1995 National Survey of Family Growth, we examine residential variation in cohabiting women's union outcomes. Prior work has shown that although there are no residential differences in cohabitation, nonmetro women are more likely than others to marry directly and hold more favorable attitudes toward marriage. Building on this work, we examined residential differences in cohabiting women's union outcomes (i.e., marriage, separation, or remaining intact) to test whether nonmetro cohabiting women's unions are more likely to “end” through marriage, and whether pregnancy has a larger positive effect on marriage entry among this group. We find that nonmetro women are less likely to remain in cohabiting unions and are more likely to either marry or separate during the first 24 months of the cohabiting union. Pregnancy during cohabitation encourages marriage and discourages separation, but these effects are not significantly larger for nonmetro women.  相似文献   
67.
Abstract We examine race and residential variation in the prevalence of female‐headed households with children and how household composition is associated with several key economic well‐being outcomes using data from the 2000 5% Public Use Microdata Sample of the U.S. Census. Special attention is paid to cohabiting female‐headed households with children and those that are headed by a single grandmother caring for at least one grandchild, because these are becoming more common living arrangements among female‐headed households with children. We find that in 2000: (1) cohabiting and grandmother female‐headed households with children comprised over one‐fourth of all female‐headed households with children, (2) household poverty is highest for female‐headed households with children that do not have other adult household earners, (3) earned income from other household members lifts many cohabiting and grandparental female‐headed households out of poverty, as does retirement and Social Security income for grandmother headed households, and (4) poverty is highest among racial/ethnic minorities and for female‐headed households with children in nonmetro compared to central cities and suburban areas.  相似文献   
68.
In monitoring clinical trials, the question of futility, or whether the data thus far suggest that the results at the final analysis are unlikely to be statistically successful, is regularly of interest over the course of a study. However, the opposite viewpoint of whether the study is sufficiently demonstrating proof of concept (POC) and should continue is a valuable consideration and ultimately should be addressed with high POC power so that a promising study is not prematurely terminated. Conditional power is often used to assess futility, and this article interconnects the ideas of assessing POC for the purpose of study continuation with conditional power, while highlighting the importance of the POC type I error and the POC type II error for study continuation or not at the interim analysis. Methods for analyzing subgroups motivate the interim analyses to maintain high POC power via an adjusted interim POC significance level criterion for study continuation or testing against an inferiority margin. Furthermore, two versions of conditional power based on the assumed effect size or the observed interim effect size are considered. Graphical displays illustrate the relationship of the POC type II error for premature study termination to the POC type I error for study continuation and the associated conditional power criteria.  相似文献   
69.
The paper analyses the various interactions among the institutional and cultural environment and the quality of entrepreneurial activity in Greece. The institutional context and the way in which institutions perform in particular, shape the structure of entrepreneurial incentives. As explicitly demonstrated by Baumol (J Political Econ 98:893–921, 1990) institutions actually channel entrepreneurial talent toward different activities which may be productive, unproductive or destructive. At the same time, informal institutions, i.e. culture and values have proven to be of equal importance for entrepreneurship. Within this context, the paper builds a simple model of rewards’ satisfaction accounting for first, the existence of income externalities, in order to test the hypothesis that individuals care about their relative position, i.e. economic status, and second, for the institutional quality, trust and values pertaining in the society, in order to analyze the possible existence of an underlying ‘social consensus’ that is supportive of rent-seeking behavior in Greece.  相似文献   
70.
Consider the problem of estimating a dose with a certain response rate. Many multistage dose‐finding designs for this problem were originally developed for oncology studies where the mean dose–response is strictly increasing in dose. In non‐oncology phase II dose‐finding studies, the dose–response curve often plateaus in the range of interest, and there are several doses with the mean response equal to the target. In this case, it is usually of interest to find the lowest of these doses because higher doses might have higher adverse event rates. It is often desirable to compare the response rate at the estimated target dose with a placebo and/or active control. We investigate which of the several known dose‐finding methods developed for oncology phase I trials is the most suitable when the dose–response curve plateaus. Some of the designs tend to spread the allocation among the doses on the plateau. Others, such as the continual reassessment method and the t‐statistic design, concentrate allocation at one of the doses with the t‐statistic design selecting the lowest dose on the plateau more frequently. Copyright © 2013 John Wiley & Sons, Ltd.  相似文献   
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