Muriel Dimen Interviewed by Andrew Samuels in the Context of the Publication of Her Book Sexuality,Intimacy, Power

Samuels interviewed Dimen in lieu of a book review for her Sexuality, Intimacy, Power. The interview was unstructured and dialogical and covered the following main topics: (a) professional issues in the field of psychoanalysis such as the relation of theory to practice and reflections on the nature and content of trainings in psychoanalysis; (b) issues in the broad areas of sexuality and gender including the question of moral relativism with respect to sexual behaviors historically designated as “perverse” and considerations of masculinity, femininity, and patriarchy; (c) intellectual considerations such as the relations between anthropology and psychoanalysis and the as yet indeterminate nature of the discipline of psychoanalysis, neither art nor science and not a hybrid of the two; and (d) the political, social, and cultural contexts within which psychoanalytic endeavors including the interview itself are taking place.     

New Lilliefors and Srinivasan tables with applications

Two approaches to the problem of goodness-of-fit with nuisance parameters are presented in this paper, both based on modifications of the Kolmogorov-Smirnov statistics. Improved tables of critical values originally computed by Lilliefors and Srinivasan are presented in the normal and exponential cases. Also given are tables for the uniform case, normal with known mean and normal with known variance. All tables were computed using Monte Carlo simulation with sample size n = 20000.     

Improved bridge constructs for stochastic differential equations

We consider the task of generating discrete-time realisations of a nonlinear multivariate diffusion process satisfying an Itô stochastic differential equation conditional on an observation taken at a fixed future time-point. Such realisations are typically termed diffusion bridges. Since, in general, no closed form expression exists for the transition densities of the process of interest, a widely adopted solution works with the Euler–Maruyama approximation, by replacing the intractable transition densities with Gaussian approximations. However, the density of the conditioned discrete-time process remains intractable, necessitating the use of computationally intensive methods such as Markov chain Monte Carlo. Designing an efficient proposal mechanism which can be applied to a noisy and partially observed system that exhibits nonlinear dynamics is a challenging problem, and is the focus of this paper. By partitioning the process into two parts, one that accounts for nonlinear dynamics in a deterministic way, and another as a residual stochastic process, we develop a class of novel constructs that bridge the residual process via a linear approximation. In addition, we adapt a recently proposed construct to a partial and noisy observation regime. We compare the performance of each new construct with a number of existing approaches, using three applications.     

Resampling-based Classification Using Depth for Functional Curves

The depths, which have been used to detect outliers or to extract a representative subset, can be applied to classification. We propose a resampling-based classification method based on the fact that resampling techniques yield a consistent estimator of the distribution of a statistic. The performance of this method was evaluated with eight contaminated models in terms of Correct Classification Rates (CCRs), and the results were compared with other known methods. The proposed method consistently showed higher average CCRs and 4% higher CCR at the maximum compared to other methods. In addition, this method was applied to Berkeley data. The average CCRs were between 0.79 and 0.85.     

Model free audit methodology for bias evaluation of tumour progression in oncology

Many oncology studies incorporate a blinded independent central review (BICR) to make an assessment of the integrity of the primary endpoint, progression free survival. Recently, it has been suggested that, in order to assess the potential for bias amongst investigators, a BICR amongst only a sample of patients could be performed; if evidence of bias is detected, according to a predefined threshold, the BICR is then assessed in all patients, otherwise, it is concluded that the sample was sufficient to rule out meaningful levels of bias. In this paper, we present an approach that adapts a method originally created for defining futility bounds in group sequential designs. The hazard ratio ratio, the ratio of the hazard ratio (HR) for the treatment effect estimated from the BICR to the corresponding HR for the investigator assessments, is used as the metric to define bias. The approach is simple to implement and ensures a high probability that a substantial true bias will be detected. In the absence of bias, there is a high probability of accepting the accuracy of local evaluations based on the sample, in which case an expensive BICR of all patients is avoided. The properties of the approach are demonstrated by retrospective application to a completed Phase III trial in colorectal cancer. The same approach could easily be adapted for other disease settings, and for test statistics other than the hazard ratio. Copyright © 2015 John Wiley & Sons, Ltd.     

An F Approximation to the Distribution of a Linear Combination of Chi-squared Variables.

A three-parameter F approximation to the distribution of a positive linear combination of central chi-squared variables is described. It is about as easy to implement as the Satterthwaite-Welsh and Hall-Buckley-Eagleson approximations. Some reassuring properties of the F approximation are derived, and numerical results are presented. The numerical results indicate that the new approximation is superior to the Satterthwaite approximation and, for some purposes, better than the Hall-Buckley-Eagleson approximation. It is not quite as good as the Gamma-Weibull approximation due to Solomon and Stephens, but is easier to implement because iterative methods are not required.     

Socially Responsible Roles of Professional Ethics: Inclusivity,Psychotherapy and ‘the Protection of the Public’

The remit of the apparatus of professional ethics in the field of psychotherapy can be appropriately expanded so as to make the profession more socially responsible and thereby contribute to the ‘protection of the public’ that is said to be the main purpose of statutory regulation. Using ideas culled from the sociology of the professions, political theory and ethical discourse, it is proposed that ethical psychotherapy cannot take place if its overall social framework is itself profoundly unethical. Inclusivity and diversity are reframed as ethical professional practices. Questions of wealth, gender, sexuality and ethnicity are not only ‘social’ or ‘political’—they are also part of a morally imaginative expansion of what we mean by professional ethics. Attention is paid to the dangers of self-righteousness and moral tyranny.