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31.
32.
Institutionalization occurs when organizations adopt policies and practices in an attempt to increase their legitimacy and competitive position. This process assumes that an organization's formal policies (macro‐level) are translated into organizational practices (micro‐level). This translation, however, can fail to occur, resulting in organizational decoupling and de‐institutionalization. Drawing on an institutionalization typology based on different levels of legitimacy (macro) and taken‐for‐grantedness (micro), the article draws on data from an assessment of the United Nations Global Compact LEAD initiative, assessing the extent to which this initiative is being institutionalized in the member firms and examining the implications for the LEAD initiative and our thinking about institutionalization.  相似文献   
33.
Biomarkers that predict efficacy and safety for a given drug therapy become increasingly important for treatment strategy and drug evaluation in personalized medicine. Methodology for appropriately identifying and validating such biomarkers is critically needed, although it is very challenging to develop, especially in trials of terminal diseases with survival endpoints. The marker‐by‐treatment predictiveness curve serves this need by visualizing the treatment effect on survival as a function of biomarker for each treatment. In this article, we propose the weighted predictiveness curve (WPC). Based on the nature of the data, it generates predictiveness curves by utilizing either parametric or nonparametric approaches. Especially for nonparametric predictiveness curves, by incorporating local assessment techniques, it requires minimum model assumptions and provides great flexibility to visualize the marker‐by‐treatment relationship. WPC can be used to compare biomarkers and identify the one with the highest potential impact. Equally important, by simultaneously viewing several treatment‐specific predictiveness curves across the biomarker range, WPC can also guide the biomarker‐based treatment regimens. Simulations representing various scenarios are employed to evaluate the performance of WPC. Application on a well‐known liver cirrhosis trial sheds new light on the data and leads to discovery of novel patterns of treatment biomarker interactions. Copyright © 2015 John Wiley & Sons, Ltd.  相似文献   
34.
Assignment of individuals to correct species or population of origin based on a comparison of allele profiles has in recent years become more accurate due to improvements in DNA marker technology. A method of assessing the error in such assignment problems is présentés. The method is based on the exact hypergeometric distributions of contingency tables conditioned on marginal totals. The result is a confidence region of fixed confidence level. This confidence level is calculable exactly in principle, and estimable very accurately by simulation, without knowledge of the true population allele frequencies. Various properties of these techniques are examined through application to several examples of actual DNA marker data and through simulation studies. Methods which may reduce computation time are discussed and illustrated.  相似文献   
35.
In survival analysis, one way to deal with non-proportional hazards is to model short-term and long-term hazard ratios. The existing model of this nature has no control over how fast the hazard ratio is changing over time. We add a parameter to the existing model to allow the hazard ratio to change over time at different speed. A nonparametric maximum likelihood approach is used to estimate the model parameters. The existing model is a special case of the extended model when the speed parameter is 0, which leads naturally to a way of testing the adequacy of the existing model. Simulation results show that there can be substantial bias in the estimation of the short-term and long-term hazard ratio if the speed parameter is fixed incorrectly at 0 rather than estimated. The extended model is fitted to three real data sets to shed new insights, including the observation that converging hazards does not necessarily imply the odds are proportional.  相似文献   
36.
This study explores obstacles to navigating the high school-to-labor market transition experienced by Second Generation Caribbean Black Male Youth (CBMY) living in Canada's Greater Toronto Area (GTA). Drawing upon interviews with ten CBMY between the ages of 18–27, the article uses a qualitative phenomenological methodology to understand barriers to education and employment from their perspectives. Studies show that 45% of CBMY drop out of high school while 52% are precariously employed in the GTA [Allahar, A. L. 2010. “The Political Economy of ‘Race’ and Class in Canada’s Caribbean Diaspora.” American Review of Political Economy 8 (2): 54; James, C. E. 2012. Students “at Risk” Stereotypes and the Schooling of Black Boys. Urban Education 47 (2), 464–494.; Lewchuk, W., and M. Lafleche. 2014. Precarious Employment and Social Outcomes. Just Labour: A Canadian Journal of Work and Society, 22, 45–50.; Block and Galabuzi 2011. Canada’s Color Coded Labor market: The Gap for Racialized workers. Canadian Centre for Policy Alternatives?=?Centre Canadien de Politiques alternatives]. The ten interview subjects provide retrospective and introspective counter-narratives that expose the race, class and gender-based barriers that frustrate their efforts to secure stable employment. The study utilizes Critical Race Theory (CRT) and the concept of White Supremacy to challenge the view that educational and employment success is based on color-blindness, merit and hard work. The CBMY counter-narratives examined in this study offer profound insight into dominant ideologies and practices that perpetuate racial biases, and present many valuable suggestions, explicit and implied, regarding how to improve the opportunities, inclusion and well-being of CBMY.  相似文献   
37.
Personal wealth has grown since the 1970s twice as fast in real terms as national income. Has this rise in the wealth-income ratio led to a corresponding increase in the wealth being passed on from one generation to the next? Are we returning to the levels of inheritance found in the 19th century? The aim of this paper is to construct UK evidence on the extent of the transmission of wealth in the form of estates and gifts inter vivos. It takes a long-run view of inheritance, starting from 1896, when the modern Estate Duty was introduced, and exploits the extensive estate data published over the years. Construction of a long-run time series for more than a century is challenging, and there are important limitations. The resulting time-series demonstrates the major importance of inheritance in the UK before the First World War, when the total transmitted wealth represented some 20 per cent of net national income. In the inter-war period, the total was around 15 per cent, falling to some 10 per cent after the Second World War, and then falling further to below 5 per cent in the late 1970s. Since then, there has indeed been an upturn: a rise from 4.8 per cent in 1977 to 8.2 per cent in 2006. This increase was more or less in line with the increase in personal wealth, and has to be interpreted in the light of the changing net worth of the corporate and public sectors of the economy.  相似文献   
38.
Public debates about the rise in top income shares often focus on the growing dispersion in earnings, and the soaring pay for top executives and financial-sector employees. But can the change in the marginal distribution of earnings on its own explain the rise in top income shares? Are top executives replacing capital owners in the group of top-income earners, or are we rather witnessing a fusion of top capital and top earnings? This paper proposes an extension of the copula framework and uses it for exploring the changing composition of top incomes. It illustrates that changes in top income shares can easily be decomposed into respective changes in the marginal distributions of labour and capital income and the changing association between the two types of income. An application using tax record data from Norway shows that the association between top labour and capital incomes grew stronger between 1995 and 2005 in the top half of the wage and capital income distribution, though it declined for the top 1% of capital income receivers. A gender decomposition demonstrates that the association of wage and capital incomes at the top is particularly striking for men, whilst women are largely under-represented in the top halves of the two marginal distributions.  相似文献   
39.
Although appearance-based cues can help to diagnose physical illness, visual manifestations of mental disorder may be more elusive. Here, we investigated whether individuals could distinguish women with a serious mental disorder (borderline personality disorder) from demographically- and IQ-matched non-psychiatric controls. Participants rated mentally ill targets as more likely to have a mental disorder from photos more accurately than chance, despite not believing that such judgments were possible. The configuration of facial cues played an important role in these judgments, as interfering with the spatial relationships between facial features reduced participants’ accuracy to chance guessing. Further investigation showed similar results when participants rated the targets for specific mental disorders (borderline personality disorder, major depressive disorder) and rated the mentally ill targets as more depressed, angry, anxious, disgusted, emotionally unstable, distressed, and less happy. Moreover, the depression ratings significantly correlated with the targets’ actual depressive symptoms. Thus, individuals may be able to infer aspects of mental disorder from minimal facial cues.  相似文献   
40.
Johan A. Oldekop  Lorenza B. Fontana  Jean Grugel  Nicole Roughton  Emmanuel A. Adu‐Ampong  Gemma K. Bird  Alex Dorgan  Marcia A. Vera Espinoza  Sara Wallin  Daniel Hammett  Esther Agbarakwe  Arun Agrawal  Nurgul Asylbekova  Clarissa Azkoul  Craig Bardsley  Anthony J. Bebbington  Savio Carvalho  Deepta Chopra  Stamatios Christopoulos  Emma Crewe  Marie‐Claude Dop  Joern Fischer  Daan Gerretsen  Jonathan Glennie  William Gois  Mtinkheni Gondwe  Lizz A. Harrison  Katja Hujo  Mark Keen  Roberto Laserna  Luca Miggiano  Sarah Mistry  Rosemary J. Morgan  Linda L. Raftree  Duncan Rhind  Thiago Rodrigues  Sonia Roschnik  Flavia Senkubuge  Ian Thornton  Simon Trace  Teresa Ore  Ren Mauricio Valds  Bhaskar Vira  Nicola Yeates  William J. Sutherland 《Development policy review : the journal of the Overseas Development Institute》2016,34(1):55-82
The Sustainable Development Goals (SDGs) herald a new phase for international development. This article presents the results of a consultative exercise to collaboratively identify 100 research questions of critical importance for the post‐2015 international development agenda. The final shortlist is grouped into nine thematic areas and was selected by 21 representatives of international and non‐governmental organisations and consultancies, and 14 academics with diverse disciplinary expertise from an initial pool of 704 questions submitted by 110 organisations based in 34 countries. The shortlist includes questions addressing long‐standing problems, new challenges and broader issues related to development policies, practices and institutions. Collectively, these questions are relevant for future development‐related research priorities of governmental and non‐governmental organisations worldwide and could act as focal points for transdisciplinary research collaborations.  相似文献   
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