Modelling human immunodeficiency virus ribonucleic acid levels with finite mixtures for censored longitudinal data

The measurement of human immunodeficiency virus ribonucleic acid levels over time leads to censored longitudinal data. Suitable models for dynamic modelling of these levels need to take this data characteristic into account. If groups of patients with different developments of the levels over time are suspected the model class of finite mixtures of mixed effects models with censored data is required. We describe the model specification and derive the estimation with a suitable expectation-maximization algorithm. We propose a convenient implementation using closed form formulae for the expected mean and variance of the truncated multivariate distribution. Only efficient evaluation of the cumulative multivariate normal distribution function is required. Model selection as well as methods for inference are discussed. The application is demonstrated on the clinical trial ACTG 315 data.     

Max-min (σ-)additiye representation of monotone measures

In non-additive measure and integration (or fuzzy measure and integral) one tries to generalise the issues of product measure and conditional expectation from the additive theory. In the discrete case successful attempts have been made via the max-min additive representation of the monotone measure and the corresponding integrals. The present paper intends to find, for arbitrary monotone measures, a max-min additive representation and, under certain topological assumptions, a representation with σ-additive measures, thus providing a powerful tool for the theory of non-additive measure and integration. Received: December 2000; revised version: September 2001     

On the probability distribution of economic growth

Three important and significantly heteroscedastic gross domestic product series are studied. Omnipresent heteroscedasticity is removed and the distributions of the series are then compared to normal, normal mixture and normal–asymmetric Laplace (NAL) distributions. NAL represents a skewed and leptokurtic distribution, which is in line with the Aghion and Howitt [1 Aghion, P. and Howitt, P. 1992. A model of growth through creative destruction. Econometrica, 60: 323–351. [Crossref], [Web of Science ®] [Google Scholar]] model for economic growth, based on Schumpeter's idea of creative destruction. Statistical properties of the NAL distributions are provided and it is shown that NAL fits the data better than the alternatives.     

Modeling individual migraine severity with autoregressive ordered probit models

This paper considers the problem of modeling migraine severity assessments and their dependence on weather and time characteristics. We take on the viewpoint of a patient who is interested in an individual migraine management strategy. Since factors influencing migraine can differ between patients in number and magnitude, we show how a patient’s headache calendar reporting the severity measurements on an ordinal scale can be used to determine the dominating factors for this special patient. One also has to account for dependencies among the measurements. For this the autoregressive ordinal probit (AOP) model of Müller and Czado (J Comput Graph Stat 14: 320–338, 2005) is utilized and fitted to a single patient’s migraine data by a grouped move multigrid Monte Carlo (GM-MGMC) Gibbs sampler. Initially, covariates are selected using proportional odds models. Model fit and model comparison are discussed. A comparison with proportional odds specifications shows that the AOP models are preferred.     

Median split, k-group split, and optimality in continuous populations

Continuous populations are grouped in many social, economic, medical, or technical fields of research. However, by grouping them, a lot of information provided by the continuous population is lost. Especially the median split, which is still adopted by many researchers, and its generalization to an equiprobable k-group split lead to a high efficiency loss. Here, this loss of information is investigated by analytical and numerical analyses for some typical symmetric and skew population distributions often found in applications. Various distribution parameters, numbers of groups, and split methods are taken from theoretical considerations and real data sets. Losses sometimes in excess of 50% can be reduced by optimal grouping.     

Electricity consumption prediction with functional linear regression using spline estimators

A functional linear regression model linking observations of a functional response variable with measurements of an explanatory functional variable is considered. This model serves to analyse a real data set describing electricity consumption in Sardinia. The interest lies in predicting either oncoming weekends’ or oncoming weekdays’ consumption, provided actual weekdays’ consumption is known. A B-spline estimator of the functional parameter is used. Selected computational issues are addressed as well.