Response‐adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?

Response‐adaptive randomisation (RAR) can considerably improve the chances of a successful treatment outcome for patients in a clinical trial by skewing the allocation probability towards better performing treatments as data accumulates. There is considerable interest in using RAR designs in drug development for rare diseases, where traditional designs are not either feasible or ethically questionable. In this paper, we discuss and address a major criticism levelled at RAR: namely, type I error inflation due to an unknown time trend over the course of the trial. The most common cause of this phenomenon is changes in the characteristics of recruited patients—referred to as patient drift. This is a realistic concern for clinical trials in rare diseases due to their lengthly accrual rate. We compute the type I error inflation as a function of the time trend magnitude to determine in which contexts the problem is most exacerbated. We then assess the ability of different correction methods to preserve type I error in these contexts and their performance in terms of other operating characteristics, including patient benefit and power. We make recommendations as to which correction methods are most suitable in the rare disease context for several RAR rules, differentiating between the 2‐armed and the multi‐armed case. We further propose a RAR design for multi‐armed clinical trials, which is computationally efficient and robust to several time trends considered.     

Public intellectuals,political satire and the birth of activist public relations: The case of Attic Comedy

The purpose of this article is to explore the origins of dissent public relations and to establish its emergence in the context of the ancient Greek comedy represented by Aristophanes. Indeed, Attic Comedy (also known as Old Comedy) was the first great example of today’s mass communication, in which political satire was used to dissent and protest against political and social circumstances in fifth-century BC Athens. This situation was conditioned by the Peloponnesian War and its political, economic and social consequences. From this perspective, this article also constitutes an investigation into the intellectual history of public relations, of which Aristophanes can be considered to be one of the first practitioners.     

Activity patterns and temporal niche partitioning of dogs and medium-sized wild mammals in urban parks of Xalapa,Mexico

Urban Ecosystems - Free-ranging domestic dogs are the world most common exotic carnivore species that could negatively interact with the native wildlife as predators, competitors, and disease...     

Measuring operational excellence: an operational excellence profitability (OEP) approach

The pursuit of operational excellence in the manufacturing industry is at rise but its measurement still lacks of appropriate indicators to determine its financial benefits. The ambiguity is due to the impact arisen from manufacturing fluctuations such as price and cost, production mix and direct and indirect parameters variations. Manufacturing fluctuations distort the cost benefit of operational excellence. This paper, therefore, proposes the OEP (Operational Excellence Profitability) indicators to isolate the impact of manufacturing fluctuation and distinctly identify the payback of operational excellence strategies and initiatives through cost benefits of achieving higher efficiency and yield. The paper presents the conceptual and mathematical development of the proposed OEP indicators and the formulas used for their calculation. Hypothetical and industrial-based investigations and applications of the OEP indicators are conducted for their validation. The results obtained from the hypothetical exercise and industrial case suggest that OEP indicators can provide an effective cost-benefit analysis of operational excellence. This would contribute in providing manufacturing organizations with more complete information regarding the performance of their processes, which will allow their directors and managers to take better decisions related to the management and improvement of their processes.     

Sexual Beliefs and Sexual Functioning: The Mediating Role of Cognitive Distraction

Dysfunctional sexual beliefs are vulnerability factors for sexual dysfunction. This cross-sectional study aimed to test the mediating role of cognitive distraction on the relationship between dysfunctional sexual beliefs about sexual functioning shared by men and women and sexual function. The authors used a sample of 421 cisgender heterosexual participants involved in a monogamous relationship. The hypothesized mediation model was tested using a bootstrapped cross product of coefficients approach. Results showed a significant negative, indirect effect between dysfunctional sexual beliefs and women's sexual function through cognitive distraction. The discussion of this study highlights the importance of cognitive factors in sexual functioning.     

COWORDS: a probabilistic model for multiple word clouds

Word clouds constitute one of the most popular statistical tools for the visual analysis of text documents because they provide users with a quick and intuitive understanding of the content. Despite their popularity for visualizing single documents, word clouds are not appropriate to compare different text documents. Independently generating word clouds for each document leads to configurations where the same word is typically located in widely different positions. This makes it very difficult to compare two or more word clouds. This paper introduces COWORDS, a new stochastic algorithm to create multiple word clouds, including one for each document. The shared words in multiple documents are placed in the same position in all clouds. Similar documents produce similar and compact clouds, making it easier to simultaneously compare and interpret several word clouds. The algorithm is based on a probability distribution in which the most probable configurations are those with a desirable visual aspect, such as a low value for the total distance between the words in all clouds. The algorithm output is a set of word clouds that are randomly selected from this probability distribution. The selection procedure uses a Markov chain Monte Carlo simulation method. We present several examples that illustrate the performance and visual results that can be obtained by our algorithm.     

Social Entrepreneur: Same or Different from the Rest?

VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - A social business responds to social problems usually ignored by institutions, mobilizing resources and generating...     

The racialized patterns of police violence: The critical importance of research as praxis

The tragic killing of George Floyd at the hands of the police resulted in hundreds of thousands of protestors marching in the streets demanding change. The call for change criticized the killing of Blacks by law enforcement and challenged White supremacy as an institution of social control and racial violence. A key component of the marches and protests was a message to the residents of the United States: “Black Lives Matter.” As society grapples with a reckoning, researchers studying police violence for the past 6 decades have been empirically and theoretically debating the reasons why use of force by law enforcement continues to have a higher proportion of Black and Brown victims compared to Whites. Although the research on fatal police killings was studied by only a small number of individuals prior to 2014, after the killing of Michael Brown in Ferguson, Missouri the research in different areas of the country increased rapidly as did the forms of analysis and research disciplines making their own contributions. The Washington Post and Guardian news agencies established that deaths at the hands of the police were occurring for at least 900 to 1100 individual deaths per year for which firearms resulted in the greatest cause of death. As US government agencies failed to produce a national data source on police involved killings, the media took a leading role in providing greater national understanding. The authors examine what role academic researchers contribute to the discussion for solutions, particularly those from marginalized backgrounds. As protestors march, lawyers sue and defend, and politicians create new forms of legislation, researchers need to play a more important role initiating critical studies, making sense of the data, and providing a theoretical framework for which police violence can be understood. This article will provide an overview of the literature on racialized police violence, point out key patterns involving racial and ethnic disparities, and emphasize how researchers can play a more important role in advocating for change.     

Protective factors and risk factors of being a victim of couple violence in women and men / Factores de riesgo y protección de ser víctima de violencia en la pareja en mujeres y hombres

The aim of this study is to determine the risk factors and protective factors of being a victim of couple violence, considering cultural conventions, coping, social support, external attribution and violence in childhood. A non-probabilistic sample of 223 women and 177 men was used. The risk factors in the sample as a whole were being male, the coping strategy of accommodation, violence in childhood and external attribution, while the protective factors were partner support and an active coping style. The study concludes with suggestions for interventions and research.     

Paired comparisons analysis: an axiomatic approach to ranking methods

In this paper we present an axiomatic analysis of several ranking methods for general tournaments. We find that the ranking method obtained by applying maximum likelihood to the (Zermelo-)Bradley-Terry model, the most common method in statistics and psychology, is one of the ranking methods that perform best with respect to the set of properties under consideration. A less known ranking method, generalised row sum, performs well too. We also study, among others, the fair bets ranking method, widely studied in social choice, and the least squares method.