Multistage Models of Carcinogenesis: An Approximation for the Size and Number Distribution of Late-Stage Clones

Multistage models have become the basic paradigm for modeling carcinogenesis. One model, the two-stage model of carcinogenesis, is now routinely used in the analysis of cancer risks from exposure to environmental chemicals. In its most general form, this model has two states, an initiated state and a neoplastic state, which allow for growth of cells via a simple linear birth-death process. In all analyses done with this model, researchers have assumed that tumor incidence is equivalent to the formation of a single neoplastic cell and the growth kinetics in the neoplastic state have been ignored. Some researchers have discussed the impact of this assumption on their analyses, but no formal methods were available for a more rigorous application of the birth-death process. In this paper, an approximation is introduced which allows for the application of growth kinetics in the neoplastic state. The adequacy of the approximation against simulated data is evaluated and methods are developed for implementing the approximation using data on the number and size of neoplastic clones.     

Problems and good practice in post-compulsory educational provision for Travellers: The Wakefield Kushti project

This paper considers the work of the Wakefield Local Education Authority (LEA) Kushti Project in the UK. This project, focused on the Traveller population in England, is aimed specifically at the post-16 Traveller population in Wakefield, West Yorkshire. Generally, the paper considers the project in three broad areas: recruitment, retention and achievement and progression. The results of the project point to the very complex challenges that educators face in their attempts to improve educational provision for Traveller families.     

Mutual Contributions of Individuals, Partners, and Institutions: Planning to Remember in Girl Scout Cookie Sales

This paper argues that planning entails distributed, mutual contributions of individuals, their social partners, and their community institutions. We suggest that these mutually involved contributions can be viewed through shifts in focus of analysis, contrasting with analyses of cognitive development that treat individuals as though they exist apart from their social and cultural worlds. We illustrate this argument with a study examining the distributed nature of planning to remember in a complex everyday task. We investigated the personal, interpersonal, and institutional cognitive contributions of 16 Girl Scouts, their mothers and customers and other companions, and institutions (the national organization and the cookie company) in keeping track of deliveries and planning collection of money in Girl Scout cookie sales and deliveries. The article also discusses an analytic methodology (Functional Pattern Analysis) for abstracting findings from the details of rich ethnographic data. Individual scouts, their mothers, customers, and the scouting organization and cookie company all played significant roles in keeping track of progress. In particular, tools and supports provided by the cookie company played a key role in organizing the cognitive tasks, and the scouts collaborated in planning with other people (usually their mothers and customers). Our findings illustrate the importance of examining contributions beyond those of the individual, while still recognizing the active roles of individuals in thinking. We argue that conceiving of individual, interpersonal, and institutional/cultural contributions as mutually constituting aspects of cognitive activities supports this aim beyond the usual focus on separate individual and ‘external’ factors.     

Perceptions and expectations of price changes and inflation: A review and conceptual framework

Drawing on relevant literature from a diverse range of academic disciplines we present a conceptual framework intended to further our understanding of perceptions and expectations of price changes and inflation. Based on this framework, we provide a detailed review of the literature and an analysis of open issues in current research. The review is primarily concerned with individuals’ perceptions and expectations of price changes and inflation, which can influence individuals’ economic behaviour (e.g. spending and saving decisions). The main insight from the review is that while consumers may have a limited ability to store and recall specific prices, and even succumb to a number of biases in the way in which they form perceptions and expectations of global price changes, they do seem to have some feel for, and ability to judge and forecast, inflation. How they achieve this, however, is still an open question, although plausible explanations have been proposed. While much important research has been undertaken and significant progress made in our understanding of the psychology of inflation, there remain many unanswered questions and interesting avenues for future research, which are discussed in the final part of the paper.     

Measuring components of family planning program effort

The measures of family planning program effort developed by Lapham and Mauldin have played a key role in family planning program analysis, but surprisingly little is known about them. This article investigates the measurement of family planning program effort based on data reflecting conditions circa 1982 in 100 developing countries. Using confirmatory factor analytic techniques, it tests some hypotheses implicit in the work of Mauldin and Lapham. Since the data do not fully support these hypotheses, an alternative conceptualization is proposed that consists of eight rather than four components. The discussion focuses on the expanded set of components and includes an assessment of the empirical indicators associated with them.     

WHAT'S IN A NAME? SOME CONFUSIONS AND CONCERNS ABOUT CONSTRUCTIVISM

As discussions about so-called 'epistemology' have receded within family therapy, discussions about te doctrine of constructivism have emerged to carry on the underlying impulse of those earlier discussions. This article contends that a constructivist epistemology is not a new doctrine in family therapy, but, rather, reflects a shift in emphasis in that discipline from a nontraditional use to the traditional use of the term "epistemology" uses that coexisted during the 'epistemology' debates of the early 1980s and that were the source of many confusions and logical contradictions. The articale also demonstrates how recent articulations of cosnstructivism have resulted in the same logical contradictions tht were committed during the earlier 'epistemology'; debates. The logic and utility of applying constructivism in particular, and epistemological analysis in general, to the practice of psychotherapy are questioned and considered.     

Re-Framing and de-Pathologizing Behavior in Therapy for Children Diagnosed with Psychosocial Disorders

The increasing number of children diagnosed with psychosocial disorders reflects a trend toward pathologizing behavior that is unusual, challenging or extreme. Although these behaviors may match items on the symptom lists for various disorders, a therapist must first consider the origin and context of those behaviors for an individual child through a non-pathological lens. This paper proposes a framework for understanding the behavior of difficult children based on core issues rather than diagnostic symptoms: arousal/excitability, range of focus, perfectionism, intensity, interpersonal sensitivity, sensory sensitivity, cognitive/perceptual style, perception of time, reaction style, and affiliation/integrity. Each trait is examined from two perspectives: how it can lead to or be interpreted as a problem, and how a therapist can re-frame the trait and build on it to identify effective interventions. This approach affirms children’s strengths and upholds social work values.Barbara Probst, Adjunct Professor is affiliated with Graduate School of Social Service, Fordham University, NY, USA.Address correspondence to Barbara Probst, MSW, LCSW, Graduate School of Social Service, Fordham University, Neperan Road, Tarrytown, NY 10591, USA; e-mail: barbprobst@aol.com     

Human capital, social capital, entrepreneurship and disability: an examination of some current educational trends in the UK

Influenced by European policy, human capital and social capital are currently of interest in UK education policy and practice, expressed particularly in the concepts of lifelong learning and entrepreneurship. Human capital and social capital ideas are shown to be flawed by not taking disability into account. The characteristics of entrepreneurship and entrepreneurship education are examined for relevance to young people with disabilities or learning difficulties and it is concluded that more could be done to develop opportunities for entrepreneurship. The position of people when work is not an option is considered, leading to the question of whether there is a 'disability industry', and an acknowledgement of the importance to the economy of disabled people as consumers and producers. A wider definition of entrepreneurship, which includes people with disabilities and learning difficulties, is sought and the paper concludes by discussing the wider implications for the learning community.