Ten steps to developing a national agenda to address financial conflicts of interest in industry sponsored clinical research

Financial liaisons between clinical researchers, research institutions, and industrial sponsors have gained momentum in recent years. In the process, it has been argued by many that trust in the research infrastructure is being eroded by the financial conflicts of interest that emerge from these arrangements. Yet, the financial resources of industry are needed to continue technology transfer from the bench to the bedside. Policy makers and government regulators are currently struggling to determine how to best manage financial conflicts of interest that emerge from these liaisons. Various organizations and government entities have proposed different strategies. This paper explores the limitations of existing measures and recommends that a unified national agenda is needed. We propose 10 steps to develop an agenda to address financial conflicts of interest in industry-sponsored clinical research.     

Nonmanipulable decision mechanisms for economic environments

In the social choice literature studying the problem of designing institutions for collective decision making, it is customary to (implicitly) assume that each dimension of the social outcome is of public interest (i.e., that each individual's welfare depends on every dimension of the outcome). Thus, the scope of the conclusions obtained is very limited. Here social decision problems with and without that public character are considered and it is shown that the same negative results arise in most cases; namely, that only dictatorial mechanisms are immune to the participants' manipulations. These results are obtained without requiring that the mechanisms produce Pareto optimal outcomes (they must simply be minimally responsive to the participants' preferences), which deepens their pessimistic character.I am deeply grateful to my advisor, Mark Walker, for his continuous guidance and encouragement. I wish also to thank Salvador Barberà, John Weymark, and two anonymous referees for helpful comments.     

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Transitional socioeconomic and political environments of public relations in Mexico

This qualitative research on the socioeconomic and political environments of public relations in Mexico documents how national context influences the practice of the profession. The evolution of public relations in Mexico has accelerated since the establishment of the North America Free Trade Agreement with the United States and Canada. This advancement is attributed to the practices of transnational corporations and the democratization process that motivates openness, greater professionalism and the expansion of public relations across diverse organizations.     

A two-stage procedure for selecting the best of k exponential distributions

The problem of selecting the best of k exponential distributions with different guarantee times and the same unknown variance is considered. A two-stage procedure, similar to the one considered by Bechhofer, Dunnett and Sobel (1954), is given. Some specific guidelines for selecting the first-stage sample size are also given.     

Peer relationships during late childhood in internationally adopted and institutionalized children

The aim of this study was to analyse the interpersonal relationships in the school context of children living in different care settings (adoptive families, residential care centres, birth families). Participants were 76 children between eight and fourteen years of age (M = 10.78, SD = 1.38), belonging to one of three groups: international adoptees, children living in residential care in Spanish institutions, and a comparison sample of Spanish children living with their birth families with no connection with child protection. Sociometric information was collected in the classroom of each child during school hours. Internationally adopted children from Russia showed considerable difficulties in their relationships with peers; they were more likely to be rejected and their peers described them as less prosocial and somewhat more aggressive. With a better sociometric position than the adoptees, children in residential care were rated by their peers as more aggressive and less prosocial than the normative population. Coordination and integrated work between the family, protection centres, schools, and other social services should be a strategic priority in the promotion of healthy social development in these groups of children.     

Some results for maximum likelihood estimation of adjusted relative risks

Maximum likelihood (ML) estimation of relative risks via log-binomial regression requires a restricted parameter space. Computation via non linear programming is simple to implement and has high convergence rate. We show that the optimization problem is well posed (convex domain and convex objective) and provide a variance formula along with a methodology for obtaining standard errors and prediction intervals which account for estimates on the boundary of the parameter space. We performed simulations under several scenarios already used in the literature in order to assess the performance of ML and of two other common estimation methods.     

Eating habits and physical activity in dieter and non-dieter youth: A gender analysis of English and Spanish adolescents

A high prevalence of youth is overweight or obese, and a frequent lack of monitoring of their weight control strategies is observed. Consequently, this paper compares the eating habits and physical activities of male and female dieters and non-dieters. Data are obtained from the large cross-national WHO collaborative study “Health Behavior in School-aged Children 2010”. The current sample consists of 9,444 students aged 11, 13 and 15 years from England and Spain. Participants are asked about dieting, vigorous and moderate-to-vigorous physical activity, breakfast frequency and fruit, vegetable, sweet and soft drink consumption. A logistic regression is used to examine the differences between dieters and non-dieters with regard to the aforementioned eating and physical activity habits. Differences between genders, countries, and those associated with BMI (body mass index) are also considered. The results suggest that the reality of weight control differs from the major health promotion recommendations during adolescence.