Using short-term evidence to predict six-month outcomes in clinical trials of signs and symptoms in rheumatoid arthritis

A model is presented to generate a distribution for the probability of an ACR response at six months for a new treatment for rheumatoid arthritis given evidence from a one- or three-month clinical trial. The model is based on published evidence from 11 randomized controlled trials on existing treatments. A hierarchical logistic regression model is used to find the relationship between the proportion of patients achieving ACR20 and ACR50 at one and three months and the proportion at six months. The model is assessed by Bayesian predictive P-values that demonstrate that the model fits the data well. The model can be used to predict the number of patients with an ACR response for proposed six-month clinical trials given data from clinical trials of one or three months duration.     

Flat rate taxes and relative poverty measurement

We provide a systematic analysis of the impact of revenue-neutral changes to the parameters of a flat rate tax system on the level of relative poverty (where the poverty line is some fraction of either the mean or the median post-tax income level). We also perform a similar analysis for a negative income tax system. We find that the choice of poverty line type has important consequences in respect of how changes to the tax parameters affect the level of relative poverty. Our results are illustrated with a numerical simulation, in which we allow the pre-tax income distribution to be either given exogenously or determined endogenously.     

Negotiating independence,choice and autonomy: experiences of parents who coordinate personal assistance on behalf of their adult son or daughter

Article 19 of the UN Convention on the Rights of Persons with Disabilities requires states to provide personal assistance services. This article is based on qualitative research in Iceland, Norway and Sweden, carried out between 2012 and 2013. The overall study focused broadly on the implementation of Article 19. This article, however, reports findings based on a particular group of participants within the larger study: non-disabled parents who coordinate personal assistance schemes for their adult son or daughter. The article examines the various ways in which the parents, the majority of whom were mothers, negotiate principles of independence, choice and autonomy for their adult son or daughter who requires intensive support, including assistance with communicating. The aim is to explore, in the context of the Convention and the principles of the independent living movement, how to acknowledge and conceptualise personal assistance schemes that require another person to manage on behalf of the user.     

The LGBQ Microaggressions on Campus Scale: A Scale Development and Validation Study

Although LGBQ students experience blatant forms of heterosexism on college campuses, subtle manifestations such as sexual orientation microaggressions are more common. Similar to overt heterosexism, sexual orientation microaggressions may threaten LGBQ students’ academic development and psychological wellbeing. Limited research exists in this area, in part due to lack of a psychometrically sound instrument measuring the prevalence of LGBQ microaggressions on college campuses. To address this gap, we created and tested the LGBQ Microaggressions on College Campuses Scale. Two correlated subscales were generated: Interpersonal LGBQ Microaggressions and Environmental LGBQ Microaggressions. The results indicated that the subscales demonstrate strong reliability and validity.     

National Networks of Corporate Power: An Irish Perspective

This paper maps the network of interlocking directorships formed by the boards of the top 50 financial and 200 non-financial companies in Ireland. The Irish network is compared with those in ten countries, based on the same sample size and selection criteria as used in this paper, using the methods and theory of Social Network Analysis (SNA). Fundamental to the paper is the idea that the network of interlocking directorates is in some way structured, and not the result of random processes.Irish boards were found to have a relatively loosely connected network structure which is sparser and less dense than those of other countries. This is reflected in the relatively low percentage of multiple directors and the relatively fewer number of directorships per multiple director.In general, indigenous Irish public companies tended to be central in the network, while a disproportionately large number of foreign and private companies were isolated on the periphery. However, a number of foreign-owned companies were central to the network -- in particular, those which started as indigenous Irish companies which were subsequently taken over.When account is taken of the nature of the Irish economy and business, in comparison with that of the ten other countries, it is seen that the opportunities for company interlinking at board level in Ireland are relatively fewer. However, within these constraints, there is a thriving network of corporate power in Ireland.     

Working Together for Better Social Work Education

This article looks at the development of user involvement in social work education at national policy level. It is written by a group of service users who are involved in Shaping Our Lives, the national independent user controlled organisation and network. The article looks at the background of user involvement in social work education and the work that Shaping Our Lives has done in the past. The new social work qualification requires user involvement in all its aspects and stages. The results so far have been patchy. Service users have made it increasingly clear that they want to be more directly involved in developing this policy alongside other stakeholders. They are particularly keen that some of the funding available goes to user controlled organisations to help develop service users' capacity to get involved and to ensure diverse involvement. The article looks at problems there have been in taking this goal forward and a positive initiative that has developed to help make it happen, led by service users, working collaboratively with other stakeholders.     

Irregular migration: policy responses in Africa and Asia

This article reviews population policies designed to curb or respond to irregular migration flows, with particular emphasis on policies adopted by governments in Africa and Asia. An overview of policies on the world level indicates a number of similarities that transcend regional lines and levels of development. Policy decisions are often influenced by the nature and attributes of the undocumented migrant population and by the current social, economic, and political situation in the receiving country. Governments are frequently more tolerant of migrants who possess needed skills or settle in sparsely populated areas that have manpower shortages. Between the 2 policy extremes of amnesty and deportation, several measures have been employed, including stricter border controls, stringent visa requirements, work permit systems, and efforts to ensure that migrants do not violate the conditions of their admission. In many cases, several policy measures are used simultaneously. Ensuring the observance of appropriate measures for the recruitment of migrant workers, their departure from the home country, and placement in employment in the country of immigration is widely regarded as the best way to prevent illegal movements of workers. Temporary worker programs are sometimes advocated to provide legal channels for potential migrants. At the national level, institutions that deal with irregular migrants tend to be limited in their mandate to a law enforcement role. In Africa, most governments have recently strengthened border and documentary controls and attempted to regulate migration through the labor market. In many cases, mass expulsions have been necessary as a result of laissez-faire policies. In Asia, on the other hand, mass deportation has been less common as a result of more stringent security measures and documentary controls. In both countries, policies have been basically reactive in response to rapidly changing political and economic conditions. Needed is an international convention to serve as a guideline for the humanitarian treatment of undocumented workers.     

Spoilers,blocking coalitions,and the core

This paper surveys non-cooperative implementations of the core which tell an intuitive story of coalition formation. Under the core solution concept, if a blocking coalition exists those agents abandon the current allocation without regard for the consequences to players outside the blocking coalition. Yet in certain circumstances, these players have an incentive to prevent formation of any blocking coalition; a game analyzed in Lagunoff (Games Econ Behav 7:54–61, 1994) is vulnerable to such circumstances. To obtain all core allocations and only core allocations, a mechanism must either restrict the actions of non-members of a proposed coalition, or ensure that non-members are unharmed by the departure of the coalition. These requirements illustrate the core’s nonchalance toward agents not in blocking coalitions. The author gives special thanks to Beth Allen and Andy McLennan for their direction, and gratefully acknowledges valuable discussions with Roger Lagunoff, Hugo Sonnenschein, John Ledyard, Myrna Wooders, Nuray Akin, as well as comments from participants at the 2004 Spring Midwest Economic Theory and the Society for Economic Design conferences and from anonymous referees. All errors remain my own. Partial funding came from National Science Foundation grants DMI-0070257 and DMI-0217974.