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61.
Jan C. H. van Eijkeren 《Risk analysis》2002,22(1):159-173
A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori. 相似文献
62.
The Exclusion of Disabled People from Positions of Power in British Voluntary Organisations 总被引:1,自引:1,他引:0
Robert F. Drake 《Disability & Society》1994,9(4):461-480
Disabled people are excluded in various ways from a wide range of social privileges, activities and institutions. Voluntary and charitable organisations promote themselves as champions of disabled people in their struggle for access to the ordinary choices and opportunities of everyday life. This paper reports the findings of an empirical study which demonstrate that in voluntary agencies governed by able-bodied people, disabled people are excluded from positions of power and influence, and they experience the same sorts of barriers and constraints as those with which they are confronted in the wider world. Furthermore, the development of agencies governed by disabled people themselves is constrained by their lack of access to money, staff and other resources. 相似文献
63.
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65.
This study investigated the gender-specific, self-reported sexual behaviors and attitudes of never-married college students attending a southeastern university in 1973 and 1988. Data were collected by means of a mailed questionnaire that remained essentially unchanged for both years. The authors found that both men and women reported an increase in heterosexual relationships that included sexual intercourse and a decrease in nonsexual relationships with the other gender. The majority of the students perceived themselves as adequately informed about sexuality and satisfied with their relationships, although the proportion of men who reported being satisfied with their relationships declined over the 15 years. The students indicated that sexuality education should focus primarily on information about AIDS and on preparation for marriage. 相似文献
66.
67.
In this part of the series, the notion of average total inspection (ATI) is introduced to ChSP-4A(c1, c2)r plans, minimizing ATI at a given process average, while protection to the consumer is given in terms of average outgoing quality limit and limiting quality level. The procedure is similar to that of Dodge and Roming. 相似文献
68.
69.
Daniel F. Skelly 《Voluntas: International Journal of Voluntary and Nonprofit Organizations》1994,4(4):555-568
Tax-exempt, non-profit organisations represent a significant and growing sector within the US economy. Between 1975 and 1990, assets of tax-exempt organisations increased in real terms by over 150 per cent while the revenue increased by over 227 per cent. This compares to a growth in real GDP of 52 per cent over the same period. A variety of tax policy issues on tax-exempt organisations and the non-profit sector can be addressed using several sources of data collected by the IRS from federal information and tax returns of exempt organisations. The Statistics of Income (SOI) Division, using sample data, conducts studies of many of the different components of the tax-exempt sector, including non-profit charitable organisations, organisations exempt under sections 501(c)(4)-(c)(9), private foundations and 4947(a) charitable trusts, and the unrelated business income of tax-exempt organisations. Income statement, balance sheet and other financial data, as well as a great amount of non-financial information, are collected in these SOI studies. The primary purposes of this article are: first, to document the role of the non-profit sector in the US economy and the evolving growth and change within the sector from the mid-1970s through to the present; and, second, to describe the ongoing SOI studies of tax-exempt organisations, the products and services available through SOI, and the future statistical plans at SOI for data collection and analysis of tax-exempt organisations and the non-profit sector. 相似文献
70.
This study examines housing quality among three groups of single-parent women: white, African-American, and Hispanic. Three
indicators of housing quality—crowding, affordability, and satisfaction—are used to discover the extent to which these groups
experience housing problems. This study also explores differences and similarities in the factors that precipitate problems
in housing quality for these three groups of single parents. Findings suggest important differences and similarities in the
nature of housing quality problems among white, African-American, and Hispanic single-parent women. The specified variables
explained about 20% of the variance in crowding, housing affordability, and housing satisfaction. On measures of objective
and subjective housing quality, white single mothers are better housed than their African-American or Hispanic counterparts.
Hispanic single mothers have the largest housing cost burden and average more persons per household than the other groups.
African-Americans are twice as likely as either group to live in low-quality housing and reported the lowest average satisfaction
with their housing.
Her research interests include housing and neighborhood assessment and women and public policy issues. She has recently published
articles inUrban Affairs Quarterly andHousing and Society on housing and neighborhood assessment criteria among black urban households and the housing cost burden of various groups
of female-headed households. She received her Ph.D. from Ohio State University.
Her research interests include the housing adjustment behavior of women and public policy. She has recently completed her
thesis on the role of noncustodial parents in determining the quality of life of their children. She is also the recipient
of the Tessie Agan Award for research excellence from the American Association of Housing Educators for a paper titled “Unterstanding
Constraints and Residential Satisfaction among Low-Income Single-Parent Families.” 相似文献