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41.
Subnational population projections in New Zealand by means of the conventional deterministic cohort-component method have had a tendency to be conservative: underprojecting fast-growing populations and overprojecting slow-growing ones. In this paper we use a stochastic population projection method as an alternative. We generate population projections for five demographically distinct administrative areas within the Waikato region of New Zealand: Hamilton City, Franklin District, Thames-Coromandel District, Otorohanga District and South Waikato District. The results are compared to official subnational deterministic projections. The accuracy of subnational population projections in New Zealand is strongly affected by the instability of migration as a component of population change. Differently from the standard cohort-component method, in which net migration levels are projected, the key parameters of our method are age-gender-area specific probabilistic net migration rates. Generally, the identified and modelled uncertainty makes the traditional ‘mid-range’ scenario of subnational deterministic projections of limited use for policy analysis or planning beyond a relatively short projection horizon. We find that the projected range of rates of population growth is wider for smaller regions and/or regions more strongly affected by net migration. Directions for further development of the methodology are suggested.  相似文献   
42.
We show how the concept of hidden Markov model may be accommodated in a setting involving multiple sequences of observations. The resulting class of models allows for both interrelationships between different sequences and serial dependence within sequences. Missing values in the observation sequences may be handled in a straightforward manner. We also examine a group of methods, based upon the observed Fisher Information matrix, for estimating the covariance matrix of the parameter estimates. We illustrate the methods with both real and simulated data sets.  相似文献   
43.
Book Review     
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44.
The author is employed in Pharmaceutical Development and is concerned with the introduction of methods designed to integrate new products and technologies with the often conflicting objectives of production, marketing, and finance.

This article outlines an approach to quantifying risk in investment appraisal and considers a marketing project although the technique has been used to appraise plant investment associated with uncertain technology and sales forecasts and also to investigate the optimal participation and financing for joint venture proposals. In addition, it is suggested that the organization of investment appraisal work may be more important than the techniques employed.  相似文献   

45.
This article compares rationales and outcome research for five areas of programming for adolescents: adolescent competence and skill development programs, family- and parent-focused programs, social integration programs, multiple component programs, and neighborhood transformation programs. The article examines program evidence for maltreated teens as well as teens coping with a variety of other challenges. The study uses a framework based on common developmental challenges and risk factors for adolescents to select and review programs.  相似文献   
46.

Background

Detection and management of antenatal risk factors is critical for quality care.

Aims

To determine (1) women’s views about when they should be asked about antenatal health factors as recommended in the Australian antenatal guidelines; and (2) the time required to provide recommended care using a clinical scenario.

Methods

In Phase 1, pregnant women attending an outpatient obstetrics clinic at a public hospital were surveyed about preferred screening for antenatal risk factors during visit(s). In Phase 2, a hypothetical clinical scenario of a woman attending her first antenatal visit with a practising midwife was video-recorded to extrapolate the time taken to ask about and offer assistance to manage clinical, screening and lifestyle risk factors.

Findings

Most women (96%) perceived they should be asked about each of the risk factors at least once (i.e. at first visit). Total time taken to ask about all risk factors was 52 min. More time was spent discussing clinical (11 min) than lifestyle factors (4 min). Adjusting for the estimated prevalence of each risk factor, the time taken to offer assistance was 8 min per woman. Average time required for detecting and offering assistance to manage risk factors is 60 min per average risk woman.

Conclusion

Women are willing to be asked about risk factors; however this process is time-consuming. Strategies to streamline visits and prioritise recommendations so time-efficient yet comprehensive care can be delivered are needed, particularly when factors require monitoring over time and for those who may be ‘at-risk’ for multiple factors.  相似文献   
47.
Recent research on finding appropriate composite endpoints for preclinical Alzheimer's disease has focused considerable effort on finding “optimized” weights in the construction of a weighted composite score. In this paper, several proposed methods are reviewed. Our results indicate no evidence that these methods will increase the power of the test statistics, and some of these weights will introduce biases to the study. Our recommendation is to focus on identifying more sensitive items from clinical practice and appropriate statistical analyses of a large Alzheimer's data set. Once a set of items has been selected, there is no evidence that adding weights will generate more sensitive composite endpoints.  相似文献   
48.
Objective: To evaluate the effectiveness of interventions targeting alcohol consumption, drug use and smoking for college/university students.Participants: College/University students.Methods: Studies were eligible if: (1)included students attending universities/colleges; (2)implemented in a university/college setting; (3)aimed to improve at least one of the following behaviors: alcohol and/or drug use and/or smoking; (4)were RCTs. The effect of the interventions on behaviors was determined by the percentage of studies that reported an effect. Due to the heterogeneity of outcomes meta-analysis was not conducted.Results: 88 studies met criteria. University-based interventions were effective for reducing alcohol-related outcomes (drinking patterns, BAC, consequences, problem drinking). Inconsistent findings for drug and smoking were observed.Conclusions: University-based interventions have the potential to improve health for students. While there is a breadth of research examining the efficacy of interventions to reduce alcohol consumption, further research is needed to determine the best approach for addressing smoking and drug use among students.  相似文献   
49.
50.
This experimental study found a main effect of perceived leadership and an interaction effect of perceived leadership and perceived severity of threats on the public's estimation of organizational crisis responses. The results indicate that the contingent theoretical argument explaining the dynamics of organizational factors and situational factors that determine stance taken by public relations practices can also be applied when explaining the outside latent public's thought patterns predicting an organizational stance and message strategy. Contingency theory offers predictive power, not just for the practitioner, but for the public passing judgment on the stance taken by an organization.  相似文献   
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