Genetic variants in ATP6 and ND3 mitochondrial genes are not associated with aggressive prostate cancer in Mexican–Mestizo men with overweight or obesity

Mitochondrial defects have been related to obesity and prostate cancer. We investigated if Mexican–Mestizo men presenting this type of cancer, exhibited somatic mutations of ATP6 and/or ND3.Body mass index (BMI) was determined; the degree of prostate cancer aggressiveness was demarcated by the Gleason score. DNA from tumor tissue and from blood leukocytes was amplified by the polymerase chain reaction and ATP6 and ND3 were sequenced. We included 77 men: 20 had normal BMI, 38 were overweight and 19 had obesity; ages ranged from 52 to 83. After sequencing ATP6 and ND3, from DNA obtained from leukocytes and tumor tissue, we did not find any somatic mutations. All changes observed, in both genes, were polymorphisms. In ATP6 we identified, in six patients, two non-synonymous nucleotide changes and in ND3 we observed that twelve patients presented non-synonymous polymorphisms. To our knowledge, this constitutes the first report where the complete sequences of the ATP6 and ND3 have been analyzed in Mexican–Mestizo men with prostate cancer and diverse BMI. Our results differ with those reported in Caucasian populations, possibly due to ethnic differences.     

Predicting online gambling self-exclusion: an analysis of the performance of supervised machine learning models

As gambling operators become increasingly sophisticated in their analysis of individual gambling behaviour, this study evaluates the potential for using machine learning techniques to identify individuals who used self-exclusion tools out of a sample of 845 online gamblers, based on analysing trends in their gambling behaviour. Being able to identify other gamblers whose behaviour is similar to those who decided to use self-exclusion tools could, for instance, be used to share responsible gaming messages or other information that aids self-aware gambling and reduces the risk of adverse outcomes. However, operators need to understand how accurate models can be and which techniques work well. The purpose of the article is to identify the most accurate technique out of four highly diverse techniques and to discuss how to deal analytically and practically with a rare event like self-exclusion, which was used by fewer than 1% of gamblers in our data-set. We conclude that balanced training data-sets are necessary for creating effective models and that, on our data-set, the most effective method is the random forest technique which achieves an accuracy improvement of 35 percentage points versus baseline estimates.     

Reflections on the concept of interculturality in the current educational debate in Argentina

In this paper, we analyze the relevance of intercultural education within contemporary educational debates in Argentina. First, we will review Argentinean legislation. Then, we will discuss the core characteristics of the Argentine educational system in order to study the historical incorporation of indigenous people into the school system. Later, we will explore concrete legislation regarding intercultural education, emphasizing the potential of such legislation as well the limitations. Finally, we will present how our findings connect to the main discussions in the field of anthropology and education.     

The effect of obesity,alcohol misuse and smoking on employment and hours worked: evidence from the Icelandic economic collapse

In this study the relationship between obesity, alcohol misuse, smoking and changes in quantity of labor supplied during an economic meltdown are examined. The data used stem from a health and lifestyle panel survey carried out by the Public Health Institute of Iceland in 2007 and 2009. Probit analysis was used to assess if pre-crisis body weight, alcohol misuse or smoking were related to subsequent job-loss or a reduction in hours worked following the 2008 economic collapse in Iceland. Results indicated that body weight, alcohol misuse and smoking are related to reductions in quantity of labor supplied for females only. Female body mass index was positively related to the probability of a reduction in quantity of labor supplied, while alcohol misuse and smoking were negatively related to the probability of decreasing hours worked for females.     

Determinants of Employment Decisions After the First Child Birth in Spain

The aim of this paper is to analyse impact of human capital on employment decisions (namely, entry and exit from employment) of first-time mothers in Spain. To carry out the analysis, we use the Fertility, Family and Values Survey of 2006. Transitions are studied via discrete-time duration models with control for frailty. The results indicate that education, previous work experience and living without a partner increase the likelihood of (re-)entering employment and decrease the likelihood of leaving employment after the first child than their low-educated, non-experienced and partnered counterparts. Women in recent cohorts register more (re-)employment transitions than the rest. However, no differences were observed in the transits out of employment across cohorts, which prove small progress in the work-life balance in Spain over the last decades. Finally, the circumstances around childbirth do not seem to influence employment decisions of first-time mothers.     

The power(lessness) of Czechoslovak Jews during the Second World War

The article evaluates the perceptions of Jewish power among the Czechoslovak exiles in Britain during the Second World War. The analysis documents the apparent persistence of prejudices against the Jewish minority among the Czechoslovak non-Jewish authorities that eventually formed the government-in-exile (1940–5), under the presidency of Edvard Bene? (1884–1948). The Czechoslovak exiles believed that the Jewish minority, in particular the Jewish nationalists (Zionists), had vehement supporters within Jewish circles in Western countries. Furthermore, they believed that the Jewish press played a significant role in the formation of public opinion in Britain and especially in the United States. In the early 1940s, the government-in-exile embarked on a policy of national homogenisation of post-war Czechoslovakia and was anxious to give concessions to the political representatives of the ethnic minority groups in exile, in particular the Germans, Hungarians and Jews. Yet the concerns about Jewish influence in liberal democracies granted several political concessions to the Jewish minority, in particular the appointment of a Zionist representative, Arno?t Frischer (1887–1954), to the exile parliament. This notwithstanding, by analysing the internal situation among the Czechoslovak Jewish groups in London, the article documents the internal weakness and disputes among the Jewish groups which gradually revealed the utter powerlessness of the Jewish exiles during their negotiations with the Czechoslovak authorities. The Jewish groups (the assimilationists, Orthodox and secular nationalists) were divided by mutual as well as internal disputes which were not concealed from outside observers and were utilised by the exile government. What emerges from the analysis is an impression of quarrelling groups that could not agree on any of the fundamental issues and whose only power was the ability to court the support of Western Jewish groups, which were perceived by the non-Jewish exiles as influential actors in US and British society.     

Service vs. manufacturing: how to address more effectively eco-innovation public policies by disentangling the different characteristics of industries

Eco-innovation is actually a fashionable topic, and several researchers are working on understanding the defining characteristics of firms that consider the environment as a priority when innovating. To date most of these studies have been carried out on manufacturing industries. This article investigates the similarities and differences among service and manufacturing firms. An empirical analysis of a sample of 5509 Spanish companies shows that the variables affecting the eco-innovative orientation of firms are quite similar. Results reveal that manufacturing firms have higher orientation toward the environment than service firms. Furthermore, highly polarized positions in environmental aspects can be found. Despite the limitations of the study, conclusions may help public policy to encourage environmental proactivity in service industry and innovation.     

On the welfare loss caused by inequality of opportunity

Based on the ethical principle of equality of opportunity, this paper presents a measure of the welfare loss that is caused by an unfair distribution of a particular outcome (income, health, education, etc). The key idea is that a fair society should produce outcomes that depend on individuals’ effort and not on their external circumstances such as gender, socioeconomic background, etc. We propose measuring inequality of opportunity as the welfare loss attributed to the outcome differences among individuals who exert a similar level of effort. Our results are in line with those aspects of fairness literature that give priority to the ex post compensation approach to equality of opportunity. Finally, we present an empirical application for the measurement of the welfare loss in the income distribution in Europe. We have observed a high degree of heterogeneity among European countries. The welfare loss due to inequality of opportunity ranges in those, from basically zero to almost one fifth of their potential welfare.     

Becoming Less Illegal: Deservingness Frames and Undocumented Migrant Incorporation

Over the last two decades, research on unauthorized migration has departed from the equation of migrant illegality with absolute exclusion, emphasizing that formal exclusion typically results in subordinate inclusion. Irregular migrants integrate through informal support networks, the underground economy, and political activities. But they also incorporate into formal institutions, through policy divergence between levels of government, bureaucratic sabotage, or fraud. The incorporation of undocumented migrants involves not so much invisibility as camouflage – presenting the paradox that camouflage improves with integration. As it reaches the formal level of claims and procedures, legalization brings up the issue of the frames through which legal deservingness is asserted. Looking at the moral economy embedded in claims and programs, we examine a series of frame tensions: between universal and particular claims to legal status, between legalization based on vulnerability and that based on civic performance, between economic and cultural deservingness, and between the policy level and individual subjectivity. We show that restrictionist governments face a dilemma when their constructions of “good citizenship” threaten to extend to “deserving” undocumented migrants. Hence, they may simultaneously emphasize deservingness frames while limiting irregular migrants’ opportunities to deserve, effectively making deservingness both a civic obligation and a civic privilege.     

Effects of Pilates method in physical fitness on older adults. A systematic review

Pilates method is employed for physical and mental conditioning. Elderly people could be benefited from a patterned and regulated conditioning work based on Pilates method. We performed a systematic review to assess the evidence on the effects of Pilates method in physical fitness on older adults. Our search included the following databases: MEDLINE-PubMed, Scopus and CINAHL Plus with Full Text via EBSCO and SPORTDiscus databases (up to April 2014). A summary of the results was performed using a best evidence synthesis and was reported according to the systematic review method proposed by Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement. The Physiotherapy Evidence Database (PEDro) scale was used to assess the methodology quality of selected studies. Seventeen experimental studies were included in this review. Fourteen were randomized controlled trials (RCT) and three clinical controlled trials (CCT). Quality scores according to PEDro indicate low quality of the included studies (range 1–6, mean 3.8?±?1.2). The most studied components related to physical fitness were neuromotor fitness (n?=?11), muscle strength (n?=?8), cardiorespiratory endurance (n?=?4), body composition (n?=?4) and flexibility (n?=?4). Results indicate that Pilates method seems to present positive effects in neuromotor fitness, especially in static and dynamic balance. Related to the other components of physical fitness (cardiorespiratory endurance, muscle strength, body composition and flexibility), contradictory results were observed. The Pilates method indicates to be an appropriate exercise modality in order to improve balance on older adults. Nevertheless, more intervention research is needed to build a solid knowledge base about the health benefits of Pilates method on older people, especially regarding the other components of physical fitness.