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191.
192.
Applied statisticians and pharmaceutical researchers are frequently involved in the design and analysis of clinical trials where at least one of the outcomes is binary. Treatments are judged by the probability of a positive binary response. A typical example is the noninferiority trial, where it is tested whether a new experimental treatment is practically not inferior to an active comparator with a prespecified margin δ. Except for the special case of δ = 0, no exact conditional test is available although approximate conditional methods (also called second‐order methods) can be applied. However, in some situations, the approximation can be poor and the logical argument for approximate conditioning is not compelling. The alternative is to consider an unconditional approach. Standard methods like the pooled z‐test are already unconditional although approximate. In this article, we review and illustrate unconditional methods with a heavy emphasis on modern methods that can deliver exact, or near exact, results. For noninferiority trials based on either rate difference or rate ratio, our recommendation is to use the so‐called E‐procedure, based on either the score or likelihood ratio statistic. This test is effectively exact, computationally efficient, and respects monotonicity constraints in practice. We support our assertions with a numerical study, and we illustrate the concepts developed in theory with a clinical example in pulmonary oncology; R code to conduct all these analyses is available from the authors. 相似文献
193.
Extant research indicates that white racial framing is utilized to rationalize discrimination, but less work has examined how the white racial frame becomes filtered into institutional settings such as corporations and instilled within its programs and practices. This paper analyzes white racial framing in the Colorado Fuel & Iron Company during the early twentieth century as part of its effort to Americanize and control its racially diverse workforce. The company developed a special unit headed by a physician and proponent of eugenics to promote “social betterment.” Our findings show how dominant racial ideologies were embedded within the company's conceptualization of social betterment and how these ideas influenced corporate programs aimed at mollifying the workforce and increasing productivity. We discuss the implications of our research for future analyses of historically embedded racial framing. 相似文献
194.
John R. Fairweather Lesley M. Hunt Chris J. Rosin Hugh R. Campbell 《Rural sociology》2009,74(3):430-454
Abstract Within the political economy of agriculture and agrofood literatures there are examples of approaches that reject simple dichotomies between alternatives and the mainstream. In line with such approaches, we challenge the assumption that alternative agriculture, and its attendant improved environmental practices, alternative management styles, less intensive approaches, and better approaches to animal and ecosystem welfare, is the only source of agricultural sustainability. This article uses national farm‐survey results for New Zealand's sheep and beef, dairy, and horticulture sectors to examine conventional farmers, measure their assessments of farming practices, and assess their environmental orientation. Analysis identifies a proenvironmental cluster of farmers in each sector characterized by a higher environmental‐orientation score and distinct ratings of other farm practices queried in the survey. We interpret the results in terms of the exposure of different agricultural sectors to the effects of market‐based, audited, best‐practice schemes. The presence of shades of “greenness” among conventional farmers has important implications for environmental management and for our understanding of the various and complex pathways toward the greening of agrofood systems. 相似文献
195.
Using Maryland administrative data between 1996 and 2005, this paper examines the impact of local labor market conditions
on work and welfare use among single mothers. Our estimates rely on the new Census Bureau Quarterly Workforce Indicators database,
which provides county-level economic indicators filtered by industry, gender, and age-group. We specify a multinomial choice
model to estimate the effects of these local labor market variables on the full set of work–welfare combinations. The results
indicate that lower unemployment rates and increased new hires and new hires’ earnings in key industries increase the likelihood
that women choose alternatives that include work. African American women and those with fewer years of education respond differently
to changing economic conditions. Our results are robust to controls for fixed effects, county-specific time trends, and endogenous
migration. 相似文献
196.
Over forty years ago, Grenander derived the MLE of a monotone decreasing density f with known mode. Prakasa Rao obtained the asymptotic distribution of this estimator at a fixed point x where f' (x) < 0. Here, we obtain the asymptotic distribution of this estimator at a fixed point x when f is constant and nonzero in some open neighborhood of x. This limiting distribution is expressible as the convolution of a closed-form density and a rescaled standard normal density. Groeneboom (1983) derived the aforementioned closed-form density and we provide an alternative, more direct derivation. 相似文献
197.
This study analyzes the associations between marital status, gender, and depressive symptoms among parents. The regression results indicate that married parents report fewer traditional depressive symptoms and lower rates of alcohol abuse than do single parents. Mothers and fathers also appear to be more likely to exhibit different depressive symptoms: Mothers are more likely than fathers to report traditional depressive symptoms and fathers are more likely to report the abuse of alcohol. Finally, we find evidence that indicators of parenting burdens such as economic strain, household labor, childcare, social support, and religious involvement mediate and moderate these relationships. 相似文献
198.
This paper focuses on interest rate models with regime switching and extends previous nonlinear threshold models by relaxing the assumption of a fixed number of regimes. Instead we suggest automatic model determination through Bayesian inference via the reversible jump Markov Chain Monte Carlo (MCMC) algorithm. Moreover, we allow the thresholds in the volatility to be driven not only by the interest rate but also by other economic factors. We illustrate our methodology by applying it to interest rates and other economic factors of the American economy. 相似文献
199.
Two trends have dominated recent sociological analyses of embodiment. There has, on the one hand, been a proliferation of analyses identifying bodies as the experiential vehicles through which we exist and interact in the world. On the other hand, this has been accompanied by a large growth in studies suggesting that technological advances have both increased our exposure to instrumental rationality and radically weakened the boundaries between humans and machines. Considered together, these trends raise an important question which has, however, been marginalised in the literature: if bodies are increasingly shaped and even constituted by the performative demands and invasive capacities of technology, what implications does this have for our lived experience of ourselves and our social and natural environment? In addressing this issue, our paper revisits Heidegger's discussion of the technological ‘enframing’ of humans and asks two questions. First, what have we lost experientially by being positioned as a ‘standing reserve’ for technologically driven demands for efficiency in contemporary society? Second, can the analysis of religious attempts to reframe human experience provide us with a perspective from outside this technological culture that enables us to appreciate the embodied experiences, dispositions and potentialities of humans in fresh ways? Our approach to these issues proceeds via a comparative study of the ‘body pedagogics’ of modern technological culture and two, very different, religious cultures. 相似文献
200.
Chris J. Ivory Neil Alderman Alfred T. Thwaites Ian P. McLoughlin Roger Vaughan 《英国管理杂志》2007,18(3):224-240
The article considers knowledge management issues from the client's perspective. In the example presented, a sludge treatment centre procured by Northumbrian Water Ltd (NWL), the task faced by the client was to manage knowledge in a context where the core technology being procured was new and resulted in the need for new knowledge to be created and shared both pre‐ and post‐delivery. In exploring these issues, the article reveals the problems of (and some solutions to) managing knowledge across the project life‐cycle and between different groups, where the motivation for generating and sharing knowledge was not the same for all participants. 相似文献