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901.
Devin Incerti Michael T. Bretscher Ray Lin Chris Harbron 《Pharmaceutical statistics》2023,22(1):162-180
While randomized controlled trials (RCTs) are the gold standard for estimating treatment effects in medical research, there is increasing use of and interest in using real-world data for drug development. One such use case is the construction of external control arms for evaluation of efficacy in single-arm trials, particularly in cases where randomization is either infeasible or unethical. However, it is well known that treated patients in non-randomized studies may not be comparable to control patients—on either measured or unmeasured variables—and that the underlying population differences between the two groups may result in biased treatment effect estimates as well as increased variability in estimation. To address these challenges for analyses of time-to-event outcomes, we developed a meta-analytic framework that uses historical reference studies to adjust a log hazard ratio estimate in a new external control study for its additional bias and variability. The set of historical studies is formed by constructing external control arms for historical RCTs, and a meta-analysis compares the trial controls to the external control arms. Importantly, a prospective external control study can be performed independently of the meta-analysis using standard causal inference techniques for observational data. We illustrate our approach with a simulation study and an empirical example based on reference studies for advanced non-small cell lung cancer. In our empirical analysis, external control patients had lower survival than trial controls (hazard ratio: 0.907), but our methodology is able to correct for this bias. An implementation of our approach is available in the R package ecmeta . 相似文献
902.
Raymond V. Gutterswijk Chris H. Z. Kuiper Frank C. P. van der Horst Joran Jongerling Annemiek T. Harder Peter Prinzie 《Child & Family Social Work》2023,28(2):454-468
Adolescents in secure residential care mostly suffer from serious behavioural problems, often accompanied by trauma and adverse family circumstances. This paper presents findings of a comparison of behavioural problems and risk factors of 255 boys and girls (aged 12 to 18 years) in secure residential care in the Netherlands and their association with behavioural problems. A cross-sectional design and standardized questionnaires were used to measure behavioural problems and individual and familial risk factors. By using independent-sample t tests, the severity of these factors in boys and girls was compared, and by using structural equation modelling (SEM), associations between these factors and behavioural problems were investigated. The findings of the study show that post-traumatic stress disorder (PTSD) symptoms, maladaptive emotion regulation, impaired perceived competence and internalizing behavioural problems were more severe in girls than in boys. Boys experienced more severe externalizing behavioural problems and more family problems than girls. Maladaptive emotion regulation, PTSD symptoms, perceived competence and parenting problems were related to behavioural problems. The results indicate that treatment for girls should address PTSD symptoms, perceived competence and maladaptive emotion regulation and that extra attention for family problems in the treatment of boys is warranted. 相似文献
903.
Chris Caplice 《Production and Operations Management》2007,16(4):423-436
A wide variety of electronic marketplace formats are used in the Truckload (TL) transportation industry, including combinatorial auctions, private and public exchanges, and electronic catalogs. Combinatorial multi‐attribute auctions are commonly used strategically to populate electronic catalogs, commonly called “routing guides,” with pricing, assignments, and priority logic. Private and public exchanges are used to complement the electronic catalogs in cases where the catalog fails. This paper discusses the TL transportation market, places the procurement of services in the context of electronic marketplace formats, and illustrates how these are currently used. 相似文献
904.
This paper explores the role of intra-company transfers in the United Kingdom government's labour immigration policy over the last quarter century. It demonstrates their role in determining the number of non-European Economic Area foreigners working in the country and examines the way policy, both generally and specifically, has developed. It presents new statistical data and uses that evidence to examine the interplay between the government and multinational corporations in the determination of a significant element of foreign labour immigration. Its findings demonstrate that intra-company transfers have consistently played a major role in the management of UK labour immigration with a small number of occupations and countries of origin characterizing the system at various times. It concludes that the system has operated through a symbiotic relationship between government and major companies to the mutual benefit of both. However, ‘Brexit’ and the COVID-19 pandemic are leading to reassessment of political and corporate objectives. 相似文献
905.
906.
Chris Jecchinis 《LABOUR》1994,8(3):547-566
ABSTRACT: Industrial relations in Greece were characterised in the past by labour-management mistrust and conflict, as well as by strong government intervention which invariably influenced the state of industrial relations. Political instability and other serious interruptions, such as World War II, the enemy occupation, civil war and two military dictatorships, made any effort for improvement very difficult, if not impossible, in the 1936-1974 period. Some concerted efforts were made later and especially in the 1980s (with EEC influence and support), which met with considerable success. A series of parliamentary acts and ministerial decrees, restored trade union freedoms, introduced statutory consultation and participation, strengthened collective bargaining, and established an independent agency for the settlement of disputes. Some degree of unity was also achieved among the major political factions represented in the trade union movement. More importantly (and in spite of their traditional reluctance to cooperate) the social partners represented on the employers‘ side by the Association of Greek Industries (SEV), and on the workers‘ side by the Greek General Confederation of Labour (GSEE) are beginning to move towards the development of innovatory systems of cooperation for the solution of problems of mutual concern. Furthermore, there are also some significant structural developments, including the establishment of a growing number of enterprise-level trade unions, which are engaged in contract negotiations and agreements, and participation at the enterprise level. Additionally, appropriate research and training on both sides are helping to meet the socio-economic challenges of the current decade and beyond. 相似文献