Statistical considerations associated with a comprehensive regulatory framework to address the unmet need for new antibacterial therapies

At present, there are situations in antibiotic drug development where the low number of enrollable patients with key problem pathogens makes it impossible to conduct fully powered non‐inferiority trials in the traditional way. Recent regulatory changes have begun to address this situation. In parallel, statistical issues regarding the application of alternative techniques, balancing the unmet need with the level of certainty in the approval process, and the use of additional sources of data are critical areas to increase development feasibility. Although such approaches increase uncertainty compared with a traditional development program, this will be necessary to allow new agents to be made available. Identification of these risks and explicit discussion around requirements in these areas should help clarify the situation, and hence, the feasibility of developing drugs to treat the most concerning pathogens before the unmet need becomes even more acute than at present. Copyright © 2014 John Wiley & Sons, Ltd.     

An investigation of the attention effects of venture capitalist backing on entrepreneurial firms

In this paper, we predict that venture capital (VC) backed initial public offerings (IPOs) will attract more attention than non-VC-backed IPOs, as VCs offer important signals to investors searching for information about entrepreneurial firms. We use a measure developed by Google (i.e., Trends) to capture the spikes in investors' attention experienced by firms in the time period surrounding their IPOs. Our results demonstrate that firms backed by VCs enjoy a far greater spike in attention than their counterparts. Furthermore, we find that firms with more prominent VCs, a larger number of VCs, and VCs situated at farther geographic distances exhibit significantly greater spikes in investors’ attention during the week of their IPO. Combined, the findings show a clear demarcation between entrepreneurial firms with or without VC backing, they bring to the fore new upshots stemming from the relationship between VCs and entrepreneurial firms, and they raise new potential questions on this relationship and beyond.     

Numbers of children looked after in England: a historical analysis

This paper is an analysis of the relationship between policy, practice and the rates of children looked after by local authorities in England. It examines the trends in the numbers of children looked after by local authorities in England over a period of approximately 40 years. The increase in children looked after in the decade after 1994 is shown to be the result of fewer children entering care, but those that do tend to stay longer. This two-part dynamic appears to have been the underlying determinant of the care population over a long period of time. The fact that time spent in care is such a key factor suggests that planning for children who are already looked after is a crucial determinant of the numbers in care. However, it is argued that poorly developed family support services limit current options for reducing the size of the care population. A range of effective family support services could potentially have an impact on the number of children in care in three ways: by helping to maintain more children within their families; by identifying those children who need care earlier; and by improving the chances of some children being successfully returned home.     

器物之用——物质性的人类学探究

当代学界对器物与物品的研究,总易建立在主体与客体、理性与感性的二分之上,从而或将器物视为社会关系或社会性的反映,或将物抽离于语境来研究。这也使得当代博物馆的建立与陈列中,器物被去除其灵性与意义,器物与其制造者、使用者、消费者,甚至博物馆参观者之间的生动联系被割裂,而成为死气沉沉之物。本文引入拉图尔的“事实拜物教”（factishism）一词,并不再局限于仅从器物的制造角度来看物,而是重新探讨器物之灵性,即器物何以通过仪式等方式而被激活,从而获得一种自主性。这样一种视角,也是对破除欧洲中心主义器物研究的有力反思。     

AIDS and Social Work: Curricula Development in an Epidemic

Abstract

The need for skilled social workers in the AIDS epidemic cannot be ignored. New graduates and current social work students need to understand complex biopsychosocial, ethical and political issues in order to provide effective, timely and appropriate services to persons with AIDS and their significant others. This article describes a framework for developing comprehensive, versatile curricula which adequately prepare students to confront the unprecedented challenges created by this epidemic.     

Counselling bereaved middle aged children: Parental suicide survivors

Suicide has spawned many books and journal articles, but the literature is sparse in discussing the grief process of middle aged sons and daughters resolving reactions to parental suicide. A developmental framework is organized into three distinct phases with interventive strategies. Each phase specifies some of the unique predicaments middle aged children may encounter in adapting to parental loss.     

“Just a hunch”: Accuracy and awareness in person perception

Person perception tasks involving nonverbal communication have a mystified reputation. It is frequently argued that nonverbal cues are accurately, but only unconsciously, perceived. This may explain the frequent response of judges who, when asked to decode a sample of nonverbal behavior, reply that it was just a hunch—i.e., show little or no awareness of how they arrived at a judgment, even a correct one. Two alternative models, the Unconsciousness hypothesis and the Inarticulation hypothesis are posited to describe the possible relationship between accuracy and awareness. Two studies are reported on the relationship between accuracy and awareness, both using the Interpersonal Perception Task (IPT). In the first study, the IPT was given to a sample of 476 undergraduates. Accuracy was measured by how many of the 30 IPT questions these judges answered correctly. Global awareness was indexed by having each judge guess how many of the 30 scenes they had answered correctly. In this coarse analysis, the accuracy-awareness relationship was positive but weak. A second experiment was conducted to produce more fine-grained tests of the accuracy-awareness relationship. Different versions of the IPT were presented to 134 undergraduates. Judges given each version of the IPT were asked to indicate their degree of confidence in each one of their answers. This second experiment found a positive, substantial relationship between accuracy and awareness, and this relationship was particularly strong when analyzed across experimental conditions as a whole. These findings support the Inarticulation hypothesis, and cast doubt on the Unconsciousness hypothesis. Implications for an emerging understanding of how nonverbal communication is processed are discussed.We wish to thank Robin Akert and Bob Rosenthal for helpful advice and inspiration.     

Differences in College Student Typical Drinking and Celebration Drinking

Abstract

Objective: The purpose of the study was to determine whether students consume alcohol in greater quantities when drinking in celebration of an event or holiday versus typical drinking use. Celebratory occasions include tailgating during football games, holidays, and the beginning and ending of academic semesters. Participants: Traditional undergraduates, ages 18 to 24, who attended the university full time in the Fall 2007 and the Spring 2008. Methods: Eight hundred participants were randomly selected to participate in the study. A stratified random sample was drawn according to class rank and sex. A total of 287 survey responses were collected. Results: Alcohol consumption was greatest during typical weekend drinking, followed by celebration drinking and then by typical weekday drinking. Conclusions: Celebration drinking was expected to be greater than typical drinking; however, typical weekend drinking episodes were greates than celebratory drinking. Intervention efforts should focus on reducing weekend alcohol consumption.