Using the Biological Two-Stage Model to Assess Risk from Short-Term Exposures

Two assumptions used in risk assessment are investigated: (1) the assumption of fraction of lifetime dose rate assumes that the risk from a fractional lifetime exposure at a given dose rate is equal to the risk from full lifetime exposure at that same fraction of the given dose rate; (2) the assumption of fraction of lifetime risk assumes that the risk from a fractional lifetime exposure at a given dose rate is equal to that same fraction of the risk from full lifetime exposure at the same dose rate. These two assumptions are equivalent when risk is a linear function of dose. Thus both can be thought of as generalizations of the assumption that cancer risk is proportional to the total accumulated lifetime dose (or average daily dose), which is often made to assess the risk from short-term exposures. In this paper, the age-specific cumulative hazard functions are derived using the two-stage model developed by Moolgavkar, Venzon, and Knudson for situations when the exposure occurs during a single period or a single instant. The two assumptions described above are examined for three types of carcinogens, initiator, completer, and promoter, in the context of the model. For initiator and completer, these two assumptions are equivalent in the low-dose region; for a promoter, using the fraction of lifetime risk assumption is generally more conservative than that of the fraction of lifetime dose rate assumption. Tables are constructed to show that the use of either the fraction of lifetime dose rate assumption or the fraction lifetime risk assumption can both underestimate and overestimate the true risk for the three types of carcinogens.     

Enjoyment of destruction: The role of uncertainty

Enjoyment is frequently associated with acts of destruction. It is posited that enjoyment derived from observing or engaging in destruction is related to the stimulus characteristics of the object being destroyed. Specifically, the factors that determine a person's enjoyment of aesthetic stimuli should also affect one's response to destruction. In the present experiment one stimulus characteristic was studied—uncertainty concerning the breaking of a pane of glass. Subjects observed a film in which three panes of glass broke immediately upon being struck, but the fourth pane of glass broke on either the first strike (low uncertainty) or the third strike (high uncertainty). Results indicated that subjects enjoyed the breaking more in the high-uncertainty condition, that is, when they were more uncertain about when the glass would break. The findings support the aesthetic theory of destruction and also have implications for design.     

Prediction for generalized linear models

Regression models are often used to make predictions. All the information needed is contained in the predictive distribution. However, this cannot be evaluated explicitly for most generalized linear models. We construct two approximations to this distribution and demonstrate their use on two sets of survival data, corresponding to the outcome of patients admitted to intensive care units and the survival times of leukaemia patients.Regression models are often used to make predictions. All the information needed is contained in the predictive distribution. However, this cannot be evaluated explicitly for most generalized linear models. We construct two approximations to this distribution and demonstrate their use on two sets of survival data, corresponding to the outcome of patients admitted to intensive care units and the survival times of leukaemia patients.Regression models are often used to make predictions. All the information needed is contained in the predictive distribution. However, this cannot be evaluated explicitly for most generalized linear models. We construct two approximations to this distribution and demonstrate their use on two sets of survival data, corresponding to the outcome of patients admitted to intensive care units and the survival times of leukaemia patients.Regression models are often used to make predictions. All the information needed is contained in the predictive distribution. However, this cannot be evaluated explicitly for most generalized linear models. We construct two approximations to this distribution and demonstrate their use on two sets of survival data, corresponding to the outcome of patients admitted to intensive care units and the survival times of leukaemia patients.     

Gonzo Justice

The role of public discourse, social control, punishment and claims about justice are joined in this essay through the concept of gonzo justice. Gonzo justice refers to the use of extraordinary means to demonstrate social control and moral compliance through rule enforcement and punishment designed to stigmatize publicly, often through the mass media, and to demonstrate the moral resolve of those mandating the punishment. The collapsing of distinctions between the news media as chroniclers of public life and formal agents of control is illustrated with materials from an ongoing study of new forms of social control. The implications of making extraordinary sanctioning practices ordinary and routine are noted.     

Working with Parents of Exceptional Children: The Need for More Careful Thought and More Positive Action

The majority of studies relating to families of handicapped children emphasise the negative emotions of the parents, particularly initial shock followed by guilt, chronic sorrow and anxiety. Rarely have these studies relied on the parents' assessments of their own reactions. As a consequence of this, there is little recognition in the relevant literature of either the wide range of parental reaction or the successful and satisfying adjustments which many parents make. A second important limitation in these studies is the absence of a theoretical framework either to test the occasional contradictions that can occur or arising out of the findings themselves.

As an alternative approach, it is suggested that a theoretical position could be developed from the concept of need recognising that the needs of the parents are distinct from those of their handicapped child, although usually consistent with them. An analysis of the research literature (Burden, 1981) has already identified five areas of need-the need for information, support, advice, access to resources and opportunities for social interaction.

It is recognised that the concept of need is a necessary but insufficient basis for an adequate theory. The notion of support coinciding with the parents' reaction to transitions in the child's life is offered as an additional factor in the family's successful adjustment. Three other variables are cited as affecting parental adjustment-individual differences in resistance to stress; the extent and nature of the child's disability and the tolerance of the community to that particular disability. In developing this theoretical framework, reference is made to some of the practical problems associated with the implementation of professional services.     

The compensation of national union presidents: Moderating effects of union size

Over the last forty years numerous reseachers from the fields of economics, finance, and human resources management have proposed and empirically evaluated a number of models in efforts to identify determinants of executive compensation. Recently, similar research efforts have been undertaken to identify compensation determinants for union officers, both at the local and national levels. As an extension of these works, this study found measures of union financial strength, job complexity, performance and tenure in office to be directly related to national union presidents’ compensation. Although union income and relative union member earnings were the strongest determinants of officer compensation for the sample of unions as a whole, analyses of three subgroups of unions based on size revealed very different findings for large as opposed to small and medium-sized unions.     

PROPERTY RIGHTS and DECISION MAKING IN THE SOVIET UNION: INTERPRETING SOVIET ENVIRONMENTAL HISTORY

Soviet history consists of two periods which differ according to degree of environmental concern. The difference is explainable in the context of a property-rights analysis of the Soviet hierarchy. In a model in which membership in the hierarchy is understood as a quasi-transferable property right, the degree of Soviet environmental conservation is directly related to the degree of stability of the hierarchy. Democratic institutions within the hierarchy serve to mitigate the informational problems that accompany collective decision making.     

What Parents Think—A Commentary

The previous article on child rearing is discussed, with particular reference to sampling limitations and the validity of the Hereford Parent Attitude Survey. Some explanations for the reported attitude differences between socioeconomic groups are advanced.